P30-CENTER CORE GRANT FOR VISION RESEARCH

这项提议的目标是建立、管理和维护核心设施，为所支持的单元提供技术支持、设备准入和人员培训。我们将建立两个核心模块，包括活体动物成像和功能分析模块，以及细胞成像和形态测量分析模块。这些模块将存放在方便的中央位置，每个模块都包含由高素质和训练有素的技术人员操作的最先进的资源，这些技术人员由初级教职员工级别的系统经理和经验丰富的高级视觉研究人员监督。多种类型的先进设备、复杂的软件和“动手”培训的可获得性将极大地提高我们的Vision Core Grant设施用户的研究成果的质量和数量。这些核心设施的成功运营将：1)增加使用临床相关和非侵入性成像程序进行严格转译研究的机会；2)产生更多需要多个专业领域的协作项目；3)提高现有研究项目的生产率，从而使参与的研究人员保持资金竞争；4)促进更多教员的招聘，包括我们目前正在采访的两名临床科学家；5)支持基于从使用PI以前无法获得的设备获取数据的新研究策略的开发。

The goals of this proposal are to create, manage and maintain core facilities that will provide technical support, equipment access and personnel training for supported modules. We will establish two core modules including Live Animal Imaging and Functional Analysis, and Cellular Imaging and Morphometric Analysis Modules. These modules will be housed in convenient central locations, each containing state-of-the-art resources operated by highly qualified and well trained technicians that are supervised by junior faculty level Systems Managers and experienced senior vision researchers. The availability of multiple types of advanced equipment, sophisticated software, and "hands on" training will dramatically increase the quality and quantity of research achievements by the users of our Vision Core Grant facilities. Successful operation of these core facilities will: 1) increase opportunities for rigorous translational research using clinically relevant and non-invasive imaging procedures, 2) generate more collaborative projects that require multiple areas of expertise, 3) increase and enhance productivity of existing research projects thereby allowing participating investigators to remain competitive for funding, 4) promote recruitment of additional faculty, including two clinician scientists whom we are currently interviewing and 5) support the development of new research strategies based on the acquisition of data from the use of equipment previously unavailable to the PI's.