P30-CENTER CORE GRANT FOR VISION RESEARCH

本提案的目标是建立、管理和维持核心设施，为支助单元提供技术支助、设备使用和人员培训。我们将建立两个核心模块，包括活体动物成像和功能分析，以及细胞成像和形态分析模块。这些模块将被安置在方便的中心位置，每个模块都包含由高素质和训练有素的技术人员操作的最先进的资源，这些技术人员由初级教师级别的系统经理和经验丰富的高级视觉研究人员监督。多种类型的先进设备，先进的软件和“动手”培训的可用性将大大提高我们的愿景核心补助金设施的用户的研究成果的质量和数量。这些核心设施的成功运作将：1）增加使用临床相关和非侵入性成像程序进行严格转化研究的机会，2）产生更多需要多个专业领域的合作项目，3）增加和提高现有研究项目的生产力，从而使参与研究者在资金方面保持竞争力，4）促进招聘更多的教师，包括我们目前正在采访的两名临床科学家，5）支持基于使用PI以前无法获得的设备获取数据的新研究策略的开发。

The goals of this proposal are to create, manage and maintain core facilities that will provide technical support, equipment access and personnel training for supported modules. We will establish two core modules including Live Animal Imaging and Functional Analysis, and Cellular Imaging and Morphometric Analysis Modules. These modules will be housed in convenient central locations, each containing state-of-the-art resources operated by highly qualified and well trained technicians that are supervised by junior faculty level Systems Managers and experienced senior vision researchers. The availability of multiple types of advanced equipment, sophisticated software, and "hands on" training will dramatically increase the quality and quantity of research achievements by the users of our Vision Core Grant facilities. Successful operation of these core facilities will: 1) increase opportunities for rigorous translational research using clinically relevant and non-invasive imaging procedures, 2) generate more collaborative projects that require multiple areas of expertise, 3) increase and enhance productivity of existing research projects thereby allowing participating investigators to remain competitive for funding, 4) promote recruitment of additional faculty, including two clinician scientists whom we are currently interviewing and 5) support the development of new research strategies based on the acquisition of data from the use of equipment previously unavailable to the PI's.