Environmental Epidemiology, Statistics and Informatics Facility Core (EESIFC)

项目摘要/摘要 位于西奈山的伊坎医学院寻求形成一个新的环境健康科学核心 中心-西奈山环境暴露对健康影响的跨学科中心。我们的 中心将利用西奈山最近的显著增长，并在国内和国际上建立我们的 公认的儿童环境健康计划。 我们中心的使命是了解早期环境暴露如何影响健康， 在整个生命周期--婴儿期、儿童期、青春期--发育与疾病和功能障碍的风险 以及更远的地方。我们将研究化学、遗传、营养和社会暴露对健康的影响，以及 它们之间的相互作用。我们的方法将是跨学科的，并具有高度的翻译性。我们将联合起来 以前沿遗传学、表观遗传学和生物信息学为基础的临床、人群和生物学研究 在以医院为基础的城市医学院的背景下。通过我们的临床和社区伙伴关系， 我们将把我们的研究成果转化为以证据为基础的疾病预防和治疗方法。 为了集中我们的研究，我们的中心将设立三个研究小组：内分泌和代谢 紊乱，神经免疫调节，氧化-抗氧化失衡。这些研究小组将带来 基础科学家、临床医生和人口科学家共同致力于开发新的、跨学科的 环境健康研究研究小组将得到三个设施核心的支持： 综合健康科学设施核心，包括暴露生物标志物、分子生物标志物、 临床人群准入和胎盘生物库；环境流行病学、统计学和 信息学设施核心；以及面向临床的表型和压力评估设施核心。这个 中心支持试点项目计划、职业发展计划和社区外展和 参与核心，致力于与不同和 西奈山所服务的弱势社区。 西奈山吸引了资金雄厚的资深教职员工，他们将成为我们中心的领导者，建成了强大的 NIEHS基金基地，建造新的实验室，组装多个预期出生队列，开发 一项成功的儿科环境健康研究培训奖学金，制定了强有力的试点项目 该计划被指定为世卫组织合作中心，并取得了重大科学发现。 NIEHS核心中心的成立将加强我们的计划认同感，保持我们的科学能力，并 帮助我们建设年轻科学家的职业生涯，他们是我们未来的领导者。

PROJECT SUMMARY/ABSTRACT The Icahn School of Medicine at Mount Sinai seeks to form a new Environmental Health Sciences Core Center-the Mount Sinai Transdisciplinary Center on Health Effects of Early Environmental Exposures. Our Center will leverage Mount Sinai's remarkable recent growth and build on our nationally and internationally recognized programs in children's environmental health. Our Center's mission is to understand how environmental exposures in early life influence health, development, and risk of disease and dysfunction across the life span - in infancy, childhood, adolescence and beyond. We will study the health impacts of chemical, genetic, nutritional, and social exposures and the interactions among them. Our approach will be transdisciplinary and highly translational. We will combine clinical, population-based and biological research with leading-edge genetics, epigenetics, and bioinformatics in the setting of a hospital-based, urban school of medicine. Through our clinical and community partnerships, we will translate our research findings into evidence-based approaches for disease prevention and treatment. To focus our research, our Center will establish three Research Groups: Endocrine and Metabolic Disruption, Neuro-Immunomodulation, and Oxidant-Antioxidant Imbalance. These Research Groups will bring together basic scientists, clinicians and population scientists committed to developing new, transdisciplinary research in environmental health The Research Groups will be supported by three Facility Cores: an Integrated Health Sciences Facility Core with Subcores in Exposure Biomarkers, Molecular Biomarkers, Clinical Population Access, and a Placenta Biobank; an Environmental Epidemiology, Statistics and Informatics Facility Core; and a clinically-oriented Phenotyping and Stress Assessment Facility Core. The Center supports a Pilot Projects Program, a Career Development Program, and a Community Outreach and Engagement Core, committed to bidirectional communication and partnership with the diverse and disadvantaged communities that Mount Sinai serves. Mount Sinai has attracted well-funded senior faculty who will be leaders in our Center, built a strong base of NIEHS funding, constructed new laboratories, assembled multiple prospective birth cohorts, developed a successful research training fellowship in pediatric environmental health, developed a robust Pilot Projects Program, gained designation as a WHO Collaborating Centre, and made significant scientific discoveries. Formation of an NIEHS Core Center will strengthen our program identity, sustain our scientific capacity, and help us build the careers of the young scientists who are our future leaders.