Incidence, Latency, and Survival of Cancer Following World Trade Center Exposure

世贸中心暴露后癌症的发病率、潜伏期和存活率

• 批准号: 9264617
• 负责人: Paolo Boffetta
• 金额: $ 44.34万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9264617
• 关键词: Incidence; Latency; Survival; Cancer; Following

Abstract: The attacks on the World Trade Center (WTC) on 9/11/2001 (9/11) involved collision of two aircraft into the buildings and the combustion of many thousands of pounds of jet fuel. The subsequent collapse on the towers, and the rescue/recovery effort that followed, led to large numbers of responders being exposed to a wide variety of hazardous material including pulverized cement, glass, asbestos, lead, polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), organochlorine pesticides, and polychlorinated furans and dioxins (1-3). Three research centers that follow cohorts of rescue and recovery workers since the WTC disaster include the Fire Department of the City of New York (FDNY); the Icahn School of Medicine at Mount Sinai (ISMMS); and the New York City Department of Health and Mental Hygiene (DOHMH). Modest though mostly non-statistically significantly elevated cancer rates post-exposure to the WTC-site have been reported in all three of the cohorts, despite limited follow-up time since 9/11/2001 (4-7). We propose to combine these three cohorts to account for individuals who are in more than one cohort, to increase the sample size, and to make the results more generalizable. We plan to update the incidence findings from the prior reports using consistent exposure and outcome definitions and taking advantage of the additional six years of follow-up since those publications. We also plan to study the time elapsed from WTC- exposure to increased incidence of WTC-associated cancer. We believe that this short-term high intensity exposure with long-term follow-up in responder cohorts, combined for these analyses, offers a rare opportunity to investigate cancer latency in humans. Finally, we also propose the first study of cancer survival in WTC rescue/recovery workers with cancer.

摘要： 2001年9月11日（9/11）对世界贸易中心（WTC）的袭击涉及两个 飞机撞向建筑物，燃烧了数千磅的喷气燃料。的 随后的塔楼倒塌，以及随后的救援/恢复工作， 暴露于各种危险材料的响应者数量，包括 水泥粉、玻璃、石棉、铅、多环芳烃（PAH）， 多氯联苯、有机氯农药和多氯呋喃， 二恶英（1-3）。三个研究中心跟踪了一批救援和恢复工作者， 世贸中心灾难包括纽约市消防局（FDNY）、伊坎学校 西奈山医学院（ISMMS）和纽约市卫生和精神卫生部 卫生（DOHMH）。癌症发病率略有上升，但大多数情况下无统计学显著性 在所有三个队列中均报告了暴露于WTC中心后的情况，尽管有限 自2001年9月11日以来的随访时间（4-7）。我们建议将这三个组别联合收割机合并， 在一个以上的队列中，增加样本量，并使 结果更加普遍。我们计划更新先前报告的发病率结果 使用一致的暴露和结果定义，并利用额外的六个 这些出版物发表后的几年。我们还计划研究从世贸中心- 暴露于WTC相关癌症的发病率增加。我们认为，这一短期 高强度暴露与应答者队列的长期随访，合并这些 分析，为研究人类癌症潜伏期提供了难得的机会。最后还 提出了第一项研究癌症生存在世贸中心救援/恢复工作者与癌症。