Biomarkers of polyoma virus infection and lung cancer among non-smokers

描述(由申请人提供)：据估计，在美国，每年有16,000-24,000例肺癌病例发生在从不吸烟的人中(占总数的15-20%)。已知的环境风险因素只解释了这些病例中的一小部分。肺结核和慢性阻塞性肺病等炎症性疾病有助于肺癌的发生，初步证据表明，已知或疑似致癌病毒的慢性感染可能是从不吸烟的人患肺癌的重要原因。多瘤病毒致癌作用的假设尚未在专门设计的流行病学研究中得到验证。这个项目的主要目的是调查感染多瘤病毒的标志物之间的联系，特别是JC病毒和BK病毒与从不吸烟的人肺癌之间的关系。血清学分析将使用经过验证的多重分析。一项回溯性病例对照研究在病例和对照分析中取得了可喜的初步结果。这一假设将在来自四项正在进行的前瞻性研究的458例不吸烟肺癌患者(以及数量相当的匹配对照)的血清样本中进行验证，其中包括两项来自亚洲的研究。血清样本的结果将在之前的病例对照研究中登记的72名肺癌患者的系列中得到验证，这些患者的肿瘤样本将被分析。这项研究将提供新的证据，支持或反对多瘤病毒感染与从不吸烟的人患肺癌之间的因果关系。确定癌症的感染原因为通过接种疫苗和根除癌症进行初级预防提供了机会。

DESCRIPTION (provided by applicant): An estimated 16,000-24,000 of lung cancer cases occur each year in the United States among never-smokers (15-20% of the total). Known environmental risk factors explain only a small proportion of these cases. Inflammatory conditions such as tuberculosis and chronic obstructive pulmonary disease contribute to lung carcinogenesis, and there is preliminary evidence that chronic infections with known or suspected oncogenic viruses may represent an important cause of lung cancer in never-smokers. The hypothesis of a carcinogenic role of polyoma viruses has not been tested in specifically designed epidemiologic studies. The overarching aim of this project is to investigate the association between markers of infection with polyoma viruses, and specifically JC virus and BK virus and lung cancer in never- smokers. A validated multiplex assay will be used for the serological analyses. Promising preliminary results have been obtained in the analysis of cases and controls from a retrospective case-control study. The hypothesis will be tested in serum samples of 458 never-smoking cases of lung cancer (and a comparable number of matched controls) from four on-going prospective studies, including two from Asia. The results of the serum samples will be validated arisen in series of 72 lung cancer patients who have been enrolled in a previous case-control study, from whom tumor samples will be analyzed. This study will provide novel evidence for or against a causal association between polyoma virus infection and lung cancer in never-smokers. The identification of infectious causes of cancer opens opportunities to primary prevention through vaccination and eradication.