ABCD-USA Consortium: Research Project

 描述(由申请人提供)：青春期是神经发育的关键时期，与物质使用率的急剧增加有关。确定物质使用的预测因素及其对儿童和青少年发育的影响至关重要，因为在正在进行的成熟过程中与物质相关的减少可能会对大脑功能以及行为、健康和心理结果产生长期影响。密歇根大学和佛罗里达大学的这项研究项目现场申请是对RFA-DA-15-015的响应，作为ABCD-USA联盟(9/13)的一部分，旨在前瞻性地确定物质使用对儿童和青少年的神经发育和行为影响。作为这项申请的一部分，将招募975名9-10岁儿童的代表性社区样本，这将有助于从ABCD-USA联盟的11个地点收集11,111个样本。所有参与者都将接受全面的基线评估，包括最先进的大脑成像、全面的神经心理测试，以及对物质使用模式和心理健康功能的广泛评估。这些全面评估将每隔两年进行一次后续评估，每隔6个月对功能和物质使用情况进行一次中期评估。在这个项目过程中收集的大脑、行为、心理、社会、遗传和环境数据将阐明：1)物质使用模式对青少年大脑的影响；2)物质使用模式的影响 物质使用对行为和健康结果的影响；3)精神病理学和物质使用模式之间的双向关系；4)个体遗传、行为、神经生物学和环境差异对风险状况和物质使用结果的影响；以及5)不同物质使用之间的“门户相互作用”。本网站独有的元素：本中心的研究项目应用程序利用特定网站的专业知识来解决两个目标，重点是确定青少年药物使用的风险和弹性因素。使用分类为不同领域(人口统计、认知、心理健康、个性、生活压力源、家族史/遗传学、环境和大脑)的基线数据，我们将使用尖端的多阶段分析方法，涉及每个领域内的数据简化(例如，潜变量分析)，识别病因不同的子组(例如，社区检测)，以及构建集成的多模式预测模型(例如，正则化回归)。这一方法将划分出具有不同风险和复原力特征的分组。这种方法对于告知青春期药物使用的结果是必不可少的，这最终将为开发更有效的干预措施提供信息，并澄清暴露对青少年大脑、健康和认知的毒性影响。

 DESCRIPTION (provided by applicant): Adolescence is a critical neurodevelopmental period that is associated with dramatic increases in rates of substance use. Identifying predictors of substance use and its effects on child and adolescent development is critically important, as substance-related decrements incurred during ongoing maturation could have long- lasting effects on brain functioning and behavioral, health, and psychological outcomes. This Research Project Site application from the University of Michigan and University of Florida is in response to RFA-DA-15-015, as part of the ABCD-USA Consortium (9/13) to prospectively determine the neurodevelopmental and behavioral effects of substance use on children and adolescents. A representative community sample of 975 9-10 year olds will be recruited as part of this application, contributing to the sample of 11,111 to be collected from 11 total sites across the ABCD-USA Consortium. All participants will undergo a comprehensive baseline assessment, including state-of-the-art brain imaging, comprehensive neuropsychological testing, and extensive assessment of substance use patterns and mental health functioning. These comprehensive assessments will occur at 2-year follow-up intervals, with intermediate assessments of functioning and substance use at 6- month intervals. The brain, behavioral, psychological, social, genetic, and environmental data collected during the course of this project will elucidate: 1) the effects of substance use patterns on the adolescent brain; 2) the effects of substance use on behavioral and health outcomes; 3) the bidirectional relationship between psychopathology and substance use patterns; 4) the effects of individual genetic, behavioral, neurobiological, and environmental differences on risk profiles and substance use outcomes; and 5) the "gateway interactions" between use of different substances. Elements Unique to this Site: This hub's Research Project application leverages site-specific expertise to address two aims focused on the identification of risk and resilience factors for adolescent substance use. Using baseline data categorized into distinct domains (Demographic, Cognitive, Mental Health, Personality, Life Stressors, Family History/Genetics, Environmental, and Brain), we will use cutting-edge, multi-stage analytic methods involving data reduction within each domain (e.g., latent variable analyses), identification of etiologically-distinct subgroups (e.g., community detection), and the construction of integrated multi-modal predictive models (e.g., regularized regression). This approach will delineate subgroups characterized by distinct profiles of risk and resilience. This approach is essential for informing outcomes of substance use during adolescence, which will ultimately inform the development of more efficacious interventions and clarify the toxic effects of exposure on adolescent brain, health, and cognition.