Deriving a de novo adolescent addiction treatment from developmental brain data

从大脑发育数据中得出青少年成瘾治疗方法

• 批准号: 10605635
• 负责人: SARAH W. FELDSTEIN EWING
• 金额: $ 17万
• 依托单位: UNIVERSITY OF RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10605635
• 关键词: Administrative Supplement; Adolescent; Alcohol abuse; Alcohols; Area; Award; Brain; Clinical; Data; Development; Funding; Image; Intervention; Learning; Link; Mentors; Mentorship; Methods; National Institute on Alcohol Abuse and Alcoholism; Process; Research; Research Personnel; Resources; Scientist; Time; Translational Research; Work; addiction; adolescent alcohol treatment; career; career development; efficacious treatment; innovation; interest; neurodevelopment; next generation; novel; patient oriented; stem; treatment response

PROJECT SUMMARY This administrative supplement within Dr. Feldstein Ewing’s Mid-Career Investigator Award (K24) aims to support PI Feldstein Ewing’s development of innovative, translational (clinical + imaging) research in adolescent alcohol treatment. The K24 protects time to facilitate her mentorship of emerging underrepresented investigators. Her career development and mentorship aims are tightly and synergistically linked to advance planned research aims. Dr. Feldstein Ewing’s 5-10 year research plan is to develop more efficacious treatment for adolescents who struggle with hazardous use. Dr. Feldstein Ewing believes that advances from this area are most likely to stem from integrative approaches that directly query the developing brain, and aims to tailor articulated interventions that are responsive to that very specific period of neural development. Translational research in adolescent addiction is very labor intensive. K24 research funding provides Dr. Feldstein Ewing with protected time from the call of administrative duties, which are often highly time intensive, but unfortunately do not advance research or mentorship. Thus, protected time available within this mechanism facilitates precisely the type of protected coverage requisite for freeing up the investigator to learn more advanced quantitative methods that are being used to maximize existing data that Dr. Feldstein Ewing already has, to propel the field forward in terms of developing novel interventions for high-need adolescents struggling with hazardous use. This protection also facilitates protected time for Dr. Feldstein Ewing to engage and involve underrepresented mentees at every stage of this process. As with many other academic centers, without this K24, this type of protected research/mentorship time would not otherwise be available to Dr. Feldstein Ewing. This coverage is crucial for advancing innovations in adolescent treatment, at a critical juncture where the resources and opportunity are available for this work to be done. This is a high area of interest and need for NIAAA; this K24 will launch a new field of scientists in this domain of adolescent alcohol and addiction research, and its intervention.

项目摘要 Feldstein Ewing博士的中期职业研究者奖（K24）的行政补充旨在 支持PI Feldstein Ewing开发创新的转化（临床+成像）研究， 青少年酒精治疗K24保护时间，以促进她对新兴的代表性不足的指导 investigators.她的职业发展和指导目标是紧密和协同联系，以促进 计划的研究目标。Feldstein Ewing博士的5-10年研究计划是开发更有效的治疗方法 为那些与危险使用作斗争的青少年。费尔德斯坦·尤因博士认为， 最有可能源于直接询问发育中的大脑的综合方法， 针对特定的神经发育阶段进行干预。平移 对青少年成瘾的研究是非常劳动密集型的。K24研究基金提供费尔德斯坦·尤因博士 有时间保护的行政职责，这往往是高度时间密集型，但 不幸的是，这并不能促进研究或指导。因此，该机制中可用的受保护时间 促进了保护范围的类型，使调查人员能够了解更多信息 先进的定量方法被用来最大限度地利用现有的数据， 在为高需求的青少年开发新的干预措施方面， 危险使用。这种保护也有利于费尔德斯坦·尤因博士参与和 让代表性不足的学员参与这一过程的每一个阶段。与许多其他学术中心一样， 如果没有这个K24，这种类型的受保护的研究/指导时间将不会提供给博士。 费尔德斯坦·尤因这一覆盖范围对于推进青少年治疗创新至关重要， 在资源和机会可供开展这项工作的关键时刻。这是一个很高的区域， 对NIAAA的兴趣和需求;这K24将在青少年这一领域推出一个新的科学家领域 酒精和成瘾研究及其干预。

项目成果

Time for a paradigm shift: The adolescent brain in addiction treatment.

• DOI: 10.1016/j.nicl.2022.102960
• 发表时间: 2022
• 期刊: NeuroImage. Clinical
• 作者: Mackiewicz Seghete KL;Filbey FM;Hudson KA;Hyun B;Feldstein Ewing SW
• 通讯作者: Feldstein Ewing SW

Randomized controlled trial of motivational interviewing for alcohol and cannabis use within a predominantly Hispanic adolescent sample.

• DOI: 10.1037/pha0000445
• 发表时间: 2022-06
• 期刊: EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
• 影响因子: 2.3
• 作者: Ewing, Sarah Feldstein;Bryan, Angela D.;Dash, Genevieve F.;Lovejoy, Travis, I;Borsari, Brian;Schmiege, Sarah J.
• 通讯作者: Schmiege, Sarah J.

Cannabinoids for the treatment of cannabis use disorder: New avenues for reaching and helping youth?

• DOI: 10.1016/j.neubiorev.2021.11.033
• 发表时间: 2021-11
• 期刊: Neuroscience & Biobehavioral Reviews
• 影响因子: 8.2
• 作者: Kristine Rømer Thomsen;B. Thylstrup;Emily A. Kenyon;R. Lees;L. Baandrup;Sarah W. Feldstein Ewing;T. Freeman

Recent tobacco use has widespread associations with adolescent white matter microstructure.

• DOI: 10.1016/j.addbeh.2019.106152
• 发表时间: 2020-02
• 期刊: Addictive behaviors
• 影响因子: 4.4
• 作者: R. Thayer;Natasha S. Hansen;S. Prashad;H. Karoly;F. Filbey;A. Bryan;Sarah W. Feldstein Ewing

Have we missed the boat? The current, preventable surge of sexually transmitted infections (STIs) in the United States.

• DOI: 10.1037/hea0000834
• 发表时间: 2020-03
• 期刊: HEALTH PSYCHOLOGY
• 影响因子: 4.2
• 作者: Ewing, Sarah W. Feldstein;Bryan, Angela D.
• 通讯作者: Bryan, Angela D.