Deriving a de novo adolescent addiction treatment from developmental brain data

项目总结 这是费尔德斯坦·尤因博士职业生涯中期调查员奖(K24)中的这一行政副刊，旨在 支持PiFeldstein Ewing的创新、转化性(临床+成像)研究 青少年酒精治疗。K24保护时间，以促进她对代表不足的新兴群体的指导 调查人员。她的职业发展和指导目标与Advance紧密而协同地联系在一起 有计划的研究目标。费尔德斯坦·尤因博士的5-10年研究计划是开发更有效的治疗方法 适用于与危险用途作斗争的青少年。费尔德斯坦·尤因博士认为，这一领域的进步 最有可能源于直接询问发育中的大脑的综合方法，目的是量身定做 对神经发育的特定时期作出反应的明确的干预措施。翻译 对青少年成瘾的研究是非常劳动密集型的。K24研究基金为费尔德斯坦·尤因博士提供 受保护的时间不受行政职责的影响，行政职责往往是高度耗时的，但 不幸的是，不要推进研究或指导。因此，这一机制内可用的保护时间 为使调查员了解更多信息所必需的保护覆盖类型提供了准确的便利 先进的定量方法被用来最大限度地利用现有数据，费尔德斯坦·尤因博士已经 已经推动这一领域向前发展，为高需要的青少年挣扎开发新的干预措施 使用危险用途。这种保护还为费尔德斯坦·尤因博士提供了受保护的时间 在这一过程的每个阶段都要让代表人数不足的指导对象参与进来。与许多其他学术中心一样， 如果没有K24，这种类型的保护性研究/指导时间就不会提供给Dr。 费尔德斯坦·尤因。这一报道对于推进青少年治疗的创新至关重要，在关键时刻 有资源和机会完成这项工作的关键时刻。这是一个很高的地区 对NIAAA的兴趣和需求；这款K24将在这一青少年领域推出一个新的科学家领域 酒精和成瘾研究及其干预。

PROJECT SUMMARY This administrative supplement within Dr. Feldstein Ewing’s Mid-Career Investigator Award (K24) aims to support PI Feldstein Ewing’s development of innovative, translational (clinical + imaging) research in adolescent alcohol treatment. The K24 protects time to facilitate her mentorship of emerging underrepresented investigators. Her career development and mentorship aims are tightly and synergistically linked to advance planned research aims. Dr. Feldstein Ewing’s 5-10 year research plan is to develop more efficacious treatment for adolescents who struggle with hazardous use. Dr. Feldstein Ewing believes that advances from this area are most likely to stem from integrative approaches that directly query the developing brain, and aims to tailor articulated interventions that are responsive to that very specific period of neural development. Translational research in adolescent addiction is very labor intensive. K24 research funding provides Dr. Feldstein Ewing with protected time from the call of administrative duties, which are often highly time intensive, but unfortunately do not advance research or mentorship. Thus, protected time available within this mechanism facilitates precisely the type of protected coverage requisite for freeing up the investigator to learn more advanced quantitative methods that are being used to maximize existing data that Dr. Feldstein Ewing already has, to propel the field forward in terms of developing novel interventions for high-need adolescents struggling with hazardous use. This protection also facilitates protected time for Dr. Feldstein Ewing to engage and involve underrepresented mentees at every stage of this process. As with many other academic centers, without this K24, this type of protected research/mentorship time would not otherwise be available to Dr. Feldstein Ewing. This coverage is crucial for advancing innovations in adolescent treatment, at a critical juncture where the resources and opportunity are available for this work to be done. This is a high area of interest and need for NIAAA; this K24 will launch a new field of scientists in this domain of adolescent alcohol and addiction research, and its intervention.