Ion channel dysfunction in the pathophysiology of Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome: diagnostic biomarkers, therapeutic targets and treatments

肌痛性脑脊髓炎/慢性疲劳综合征病理生理学中的离子通道功能障碍：诊断生物标志物、治疗靶点和治疗方法

• 批准号: nhmrc : 1199502
• 金额: $ 146.07万
• 依托单位国家: 澳大利亚
• 项目类别: Targeted Calls for Research
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/ion-channel-dysfunction-targets-treatments/1779555
• 关键词: Ion; channel; dysfunction; pathophysiology; Myalgic

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is an illness affecting up to 240,000 Australians. The cause of ME/CFS is not known, and there are currently no diagnostic tests or effective treatments. Research suggests that ion channels that transfer calcium within cells are dysfunctional in ME/CFS. Our research will investigate ion channels and calcium transfer using immune cells to help develop biomarkers for the illness and discover better treatments for these patients.

肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）是一种影响多达24万澳大利亚人的疾病。ME/CFS的原因尚不清楚，目前没有诊断测试或有效的治疗方法。研究表明，在ME/CFS中，细胞内转移钙的离子通道功能失调。我们的研究将使用免疫细胞研究离子通道和钙转移，以帮助开发疾病的生物标志物，并为这些患者发现更好的治疗方法。