权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Modified Elliptical Centric View Orders for Improved Real-Time MRA

改进的椭圆中心视图顺序以改进实时 MRA

基本信息

批准号：
8899345
负责人：
Stephen J Riederer
金额：
$ 44.03万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
1984
资助国家：
美国
起止时间：
1984-08-01 至 2017-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8899345
关键词：
Abdomen Acceleration Accounting Address Anatomy Angiography Applications Grants Blood flow Blushing Bolus Infusion Brain Calibration Cardiovascular Diseases Carotid Arteries Computer software Custom Data Data Set Development Diagnosis Dose Elements Funding Goals Grant Hand Image Individual Inferior Injection of therapeutic agent Intravenous Magnetic Resonance Imaging Methods Morphologic artifacts Motion Noise Organ Patients Performance Perfusion Phase Physics Physiologic pulse Population Positioning Attribute Principal Investigator Process RF coil Resolution Respiration Route Sampling Scanning Signal Transduction Slice Techniques Testing Time United States United States National Institutes of Health Update Upper Extremity Veins Work aortic arch base contrast enhanced data acquisition foot improved intracranial artery reconstruction renal artery temporal measurement

项目摘要

DESCRIPTION (provided by applicant): The overall purpose of this grant application is to further draw on the extensive developments made in contrast-enhanced MR angiography (CE-MRA) during the previous funding cycle and push the field to even higher levels. The last several years have seen multiple developments in CE-MRA, and we believe that the work of our own group has contributed materially to this. Specific developments include: (i) demonstration of a signal enhancement effect when 2D parallel acquisition is applied to elliptical centric CE-MRA; (ii) demonstration of improved vessel sharpness in accelerated CE-MRA; (iii) development of the Cartesian Acquisition with Projection-Reconstruction-like sampling (CAPR) pulse sequence for time-resolved CE-MRA; (iv) routine demonstration of acceleration factors exceeding 10 in CE-MRA; (v) development of modular coil arrays for accelerated CE-MRA; (v) demonstration that CAPR provides high fidelity in the portrayal of dynamic phenomena; and (vi) routine demonstration of high quality time-resolved 3D CE-MR angiograms of the brain and calves. Specific aims to be studied are: 1. High Quality Comprehensive Neurovascular Exam. In an extension of the work performed during Years 20- 23 we will generate high quality images of the vasculature of the aortic arch, carotid arteries, intracranial arteries, and the draining veins of he brain in one comprehensive exam. The traditional test bolus used to assess timing in a 2D slice will be replaced with a low dose (1-2 ml) 3D time-resolved CE-MRA sequence. This will be followed by normal dose (18 ml) acquisition in which multi-element, modular RF coil arrays will allow 2D accelerated acquisition, providing high spatial resolution data sets for all territories. . High Resolution CAPR of the Upper Extremities and Abdomen. Parallel acquisition techniques previously developed for MR angiography of the brain and calves will be adapted to other anatomic regions. For each region the modular coil array elements will be matched to the specific field-of-view (FOV) and desired spatial resolution. For the hands the FOV is typically asymmetric (L/R vs. A/P), suggesting that elements having different sizes be used as for the calves. For the abdomen the increased FOV calls for larger coil elements. 3. Combined Angiographic and Perfusion MR Imaging. Analysis of the signal levels in brain parenchyma from CAPR CE-MRA studies of the brain has shown that first-pass parenchymal "blush" is detectable, suggesting the potential for providing perfusion information from the angiographic data set. However, this can be limited by a frame time which is still marginally too long and SNR which is marginally too small. To address this we will adapt the basic CAPR sequence for improved temporal resolution using 2D SENSE acceleration factors of ten-fold and higher. To retain SNR, particularly within the parenchymal signal, we will apply recently developed compressive sensing methods. 1

描述（由申请人提供）：本资助申请的总体目的是进一步利用上一个资助周期中对比增强MR血管造影（CE-MRA）的广泛发展，并将该领域推向更高水平。在过去的几年里，CE-MRA取得了多方面的发展，我们相信我们自己的工作组对此做出了重大贡献。具体发展包括：（i）当2D并行采集应用于椭圆中心CE-MRA时的信号增强效果的演示;（ii）在加速CE-MRA中改善血管清晰度的演示;（iii）用于时间分辨CE-MRA的具有投影重建样采样（CAPR）脉冲序列的笛卡尔采集的开发;（iv）在CE-MRA中加速因子超过10的常规演示;（v）开发用于加速CE-MRA的模块化线圈阵列;（v）证明CAPR在动态现象的描绘中提供高保真度;以及（vi）常规展示大脑和小腿的高质量时间分辨3D CE-MR血管造影。研究的具体目标是：1。高质量的综合神经血管检查。在20- 23年期间进行的工作的扩展中，我们将生成主动脉弓，颈动脉，颅内动脉，用于评估2D切片中时间的传统测试团注将被低剂量（1-2 ml）3D时间分辨CE取代，MRA序列。随后将进行正常剂量（18 ml）采集，其中多元件模块化RF线圈阵列将允许2D加速采集，为所有区域提供高空间分辨率数据集。.上肢和腹部的高分辨率CAPR。并行采集技术以前开发的磁共振血管造影的大脑和小腿将适用于其他解剖区域。对于每个区域，模块化线圈阵列元件将与特定的视场（FOV）和期望的空间分辨率相匹配。对于手，FOV通常是不对称的（L/R对A/P），这表明对于小腿使用具有不同尺寸的元件。对于腹部，增加的FOV要求更大的线圈元件。3.血管造影和灌注磁共振成像的组合。对大脑CAPR CE-MRA研究中脑实质信号水平的分析表明，可以检测到首过脑实质“脸红”，这表明有可能从血管造影数据集中提供灌注信息。然而，这可能受到仍然稍微太长的帧时间和稍微太小的SNR的限制。为了解决这个问题，我们将使用10倍或更高的2D SENSE加速因子调整基本CAPR序列以提高时间分辨率。为了保持SNR，特别是在实质信号内，我们将应用最近开发的压缩感知方法。1