Mesothelioma Virtual Bank for Translational Research

描述（由申请人提供）：拟议的间皮瘤虚拟银行（MVB）转化研究将创建和维护基础设施，以支持国家虚拟患者登记和组织库。MVB建议通过一个合作工作组创建和维护一套资源，该工作组将提供间皮瘤组织的独立存储供公众访问。MVB将使用一个集中的基于互联网的数据库或登记处，该数据库或登记处仿照宾夕法尼亚癌症联盟生物信息学联盟（PCABC，见http://pcabc.upmc.edu）创建的虚拟组织库登记处。MVB登记研究将用于记录和收集与每个组织样本（血清、组织或DMA）相关的数据。各参与机构将负责将其每份样本的数据录入并更新至登记研究中。该登记处将由匹兹堡大学团队与CDC和NIOSH合作建立和管理，并通过该合作协议获得CDC和NIOSH的指导。MVB的营销和推广工作将通过与跨社区翻译研究（TRAC）合作来完成。除了向研究界的潜在用户积极宣传这一资源的可用性外，TRAC还将利用其与患者倡导界的深厚联系，与这一根深蒂固的群体进行对话。该社区的教育和直接参与将为MVB获得一般和财政支持，这对于维持组织库、信息学工具和患者登记工作人员是必要的，这些对这一重要计划的长期可行性至关重要。

DESCRIPTION (provided by applicant): The proposed Mesothelioma Virtual Bank (MVB) for Translational Research will create and maintain infrastructure to support a national virtual patient registry and tissue bank. MVB proposes to create and maintain a set of resources through a cooperative working group that will make available their independent stores of mesothelioma tissue for public access. MVB will use a centralized internet-based database or registry modeled after the virtual tissue bank registry created by the Pennsylvania Cancer Alliance Bioinformatics Consortium (PCABC, see http://pcabc.upmc.edu). The MVB registry will be used for data recording and collection related to each tissue sample (serum, tissue or DMA). Each participating institution will be responsible for the data entry and updates into the registry for each of their samples. The registry will be established and managed by the University of Pittsburgh team in collaboration with, and guidance from the CDC and NIOSH via this cooperative agreement. Marketing and outreach efforts of the MVB will be accomplished by partnering with Translating Research Across Communities (TRAC). In addition to actively publicizing the availability of this resource to prospective users in the research community, TRAC will capitalize on its deep linkages to the Patient Advocacy Community to create a dialogue with this deeply vested population. Education and direct involvement of this Community will garner general as well as fiscal support for the MVB that will be necessary to sustain the tissue bank, informatics tools and patient registry staff critical to the long term viability of this important program.