Gordon Research Conference on "Infections of the nervous system: Pathogenesis and Worldwide Impact1"

戈登研究会议“神经系统感染：发病机制和全球影响1”

• 批准号: 8986297
• 负责人: SUSAN R ROSS
• 金额: $ 0.7万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8986297
• 关键词: Address; Affect; Animal Model; Arboviruses; Awareness; Bacterial Meningitis; Basic Science; Cell physiology; Cells; Cerebral Malaria; Cessation of life; Characteristics; Chikungunya virus; Clinical; Clinical Research; Collaborations; Communities; Country; Development; Diagnostic; Disease; Disease Outbreaks; Dourine; Fatal Outcome; Fellowship; Fostering; France; Functional disorder; Goals; Grant; HIV; Human; Immune; Immunology; Impairment; Infection; Infectious Agent; Insect Vectors; Institutes; Institution; International; Invaded; Investigation; Knowledge; Left; Location; London; Medical; Medical Research; Mission; Molecular; Molecular Genetics; National Institute of Neurological Disorders and Stroke; Nature; Nervous System Trauma; Nervous system structure; Neuraxis; Neurologic; Neurons; Oral; Organ; Outcome; Participant; Pathogenesis; Patients; Plague; Planets; Prevention; Primates; Principal Investigator; Rabies; Research; Research Personnel; Research Training; Resources; Rodent; Science; Scientist; Sensory; Series; Services; Singapore; Site; Societies; South Africa; Survivors; Therapeutic; Time; Toxoplasmosis; Training Programs; United Kingdom; Universities; Visit; West Nile virus; Work; adaptive immunity; base; burden of illness; cell motility; climate change; cognitive function; college; disease mechanisms study; drug discovery; global health; improved; lectures; man; meetings; member; multidisciplinary; nervous system disorder; nervous system infection; neurotropic; new technology; pathogen; patient oriented research; posters; prognostic tool; public health relevance; receptor; relating to nervous system; response; socioeconomics; success; symposium; therapy development; tool

 DESCRIPTION (provided by applicant): The burden of diseases caused by neurotropic pathogens often result in neurological sequelae that affect motility, sensory organs and cognitive functions in survivors. This in turn impairs socio-economic progress, especially in tropical regions where such diseases are particularly prevalent. With increasing manifestations of climate changes affecting our planet, pathogens spread by insect vectors may move to other regions, indicating how these pathogens have such a profound impact on neural cell function causing either a fatal outcome or debilitating, prolonged neurological impairment. As the central nervous system is usually not the primary target site of infection, a window of opportunity exists to interfere with pathogen spreading. It is crucial to develop therapies for neurological diseases that result in long lasting disease burden and impact on society. The Gordon Research Conference on "Infections of the nervous system", the 2nd of this series will advance knowledge in the field and promote exchanges between medical research centers in resource-rich and -poor regions. The format of GRC (community-based, small audience, focus on unpublished material) is ideal to create a multidisciplinary dialogue that will involve both clinicians and scientists studying disease mechanisms and host genetics, the molecular make-up of neurotropic infectious agents, and the innate and adaptive immune response to neurotropic pathogens. This series will bring together renowned clinicians and scientists, who investigate disease manifestations and molecular mechanisms underlying worldwide infections of the nervous system in humans that will further foster collaborations to accelerate investigations in the development of diagnostic/prognostic tools and pioneering therapeutics. The establishment of a strong community of top-ranked scientists working on infections of the nervous system will increase the awareness of world-leading research institutions on the impact and challenges in this field and foster new research and training programs in this topic. The conference will open with keynote lectures followed by scientific sessions that will address: how ways of invading the nervous system vary between pathogens; what are the specific neural target cells and their receptors for neurotropic pathogens; what are the characteristics of the immune and neural responses to invading pathogens; how clinical and pathogenesis studies can elucidate the nature of the nervous system damage caused by different pathogens; what are the new prospects for therapies and diagnostic in some of the diseases covered. Another important objective of this conference is to attract young researchers from all continents in the field. Thes trainees will present posters and/or short oral presentations, giving them ample time to discuss their work with the experts. Success of this grant will be instrumental in providing this opportunity to younger researchers to participant and contribute, thus advancing the mission of NINDS by expanding the knowledge on clinical and pathogenesis of devastating neurological diseases, and promoting progress in their prevention, diagnostic and therapies.

 描述（由申请人提供）：嗜神经病原体引起的疾病负担通常会导致神经系统后遗症，影响幸存者的运动能力、感觉器官和认知功能。这反过来又损害了社会经济进步，特别是在此类疾病特别普遍的热带地区。随着气候变化影响我们星球的现象日益增多，通过昆虫媒介传播的病原体可能会转移到其他地区，这表明这些病原体如何对神经细胞功能产生如此深远的影响，导致致命的结果或使人衰弱、长期的神经损伤。由于中枢神经系统通常不是感染的主要目标部位，因此存在干扰病原体传播的机会之窗。开发神经系统疾病的治疗方法至关重要，这些疾病会导致长期的疾病负担和对社会的影响。 关于“神经系统感染”的戈登研究会议是该系列的第二次会议，将推进该领域的知识并促进资源丰富和贫困地区医学研究中心之间的交流。 GRC（基于社区、小受众、关注未发表的材料）的形式非常适合创建多学科对话，临床医生和科学家将共同研究疾病机制和宿主遗传学、嗜神经感染因子的分子组成以及对嗜神经病原体的先天和适应性免疫反应。该系列将汇集著名的临床医生和科学家，他们研究全球范围内人类神经系统感染的疾病表现和分子机制，这将进一步促进合作，加速诊断/预后工具和开创性治疗方法开发的研究。 建立一个由研究神经系统感染的顶级科学家组成的强大社区，将提高世界领先研究机构对该领域影响和挑战的认识，并促进该主题的新研究和培训项目。会议将以主题演讲开始，随后举行科学会议，会议将讨论：不同病原体入侵神经系统的方式有何不同；嗜神经病原体的特定神经靶细胞及其受体是什么？对入侵病原体的免疫和神经反应有何特点？临床和发病机制研究如何阐明不同病原体引起的神经系统损伤的性质；所涵盖的一些疾病的治疗和诊断的新前景是什么？本次会议的另一个重要目标是吸引来自各大洲该领域的年轻研究人员。学员将展示海报和/或简短的口头演讲，让他们有充足的时间与专家讨论他们的工作。这笔赠款的成功将有助于为年轻研究人员提供参与和贡献的机会，从而通过扩大对毁灭性神经系统疾病的临床和发病机制的了解，并促进其预防、诊断和治疗的进展，推进 NINDS 的使命。