Gordon Research Conference on "Infections of the nervous system: Pathogenesis and Worldwide Impact1"

戈登研究会议“神经系统感染：发病机制和全球影响1”

• 批准号: 8986297
• 负责人: SUSAN R ROSS
• 金额: $ 0.7万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8986297
• 关键词: Address; Affect; Animal Model; Arboviruses; Awareness; Bacterial Meningitis; Basic Science; Cell physiology; Cells; Cerebral Malaria; Cessation of life; Characteristics; Chikungunya virus; Clinical; Clinical Research; Collaborations; Communities; Country; Development; Diagnostic; Disease; Disease Outbreaks; Dourine; Fatal Outcome; Fellowship; Fostering; France; Functional disorder; Goals; Grant; HIV; Human; Immune; Immunology; Impairment; Infection; Infectious Agent; Insect Vectors; Institutes; Institution; International; Invaded; Investigation; Knowledge; Left; Location; London; Medical; Medical Research; Mission; Molecular; Molecular Genetics; National Institute of Neurological Disorders and Stroke; Nature; Nervous System Trauma; Nervous system structure; Neuraxis; Neurologic; Neurons; Oral; Organ; Outcome; Participant; Pathogenesis; Patients; Plague; Planets; Prevention; Primates; Principal Investigator; Rabies; Research; Research Personnel; Research Training; Resources; Rodent; Science; Scientist; Sensory; Series; Services; Singapore; Site; Societies; South Africa; Survivors; Therapeutic; Time; Toxoplasmosis; Training Programs; United Kingdom; Universities; Visit; West Nile virus; Work; adaptive immunity; base; burden of illness; cell motility; climate change; cognitive function; college; disease mechanisms study; drug discovery; global health; improved; lectures; man; meetings; member; multidisciplinary; nervous system disorder; nervous system infection; neurotropic; new technology; pathogen; patient oriented research; posters; prognostic tool; public health relevance; receptor; relating to nervous system; response; socioeconomics; success; symposium; therapy development; tool

 DESCRIPTION (provided by applicant): The burden of diseases caused by neurotropic pathogens often result in neurological sequelae that affect motility, sensory organs and cognitive functions in survivors. This in turn impairs socio-economic progress, especially in tropical regions where such diseases are particularly prevalent. With increasing manifestations of climate changes affecting our planet, pathogens spread by insect vectors may move to other regions, indicating how these pathogens have such a profound impact on neural cell function causing either a fatal outcome or debilitating, prolonged neurological impairment. As the central nervous system is usually not the primary target site of infection, a window of opportunity exists to interfere with pathogen spreading. It is crucial to develop therapies for neurological diseases that result in long lasting disease burden and impact on society. The Gordon Research Conference on "Infections of the nervous system", the 2nd of this series will advance knowledge in the field and promote exchanges between medical research centers in resource-rich and -poor regions. The format of GRC (community-based, small audience, focus on unpublished material) is ideal to create a multidisciplinary dialogue that will involve both clinicians and scientists studying disease mechanisms and host genetics, the molecular make-up of neurotropic infectious agents, and the innate and adaptive immune response to neurotropic pathogens. This series will bring together renowned clinicians and scientists, who investigate disease manifestations and molecular mechanisms underlying worldwide infections of the nervous system in humans that will further foster collaborations to accelerate investigations in the development of diagnostic/prognostic tools and pioneering therapeutics. The establishment of a strong community of top-ranked scientists working on infections of the nervous system will increase the awareness of world-leading research institutions on the impact and challenges in this field and foster new research and training programs in this topic. The conference will open with keynote lectures followed by scientific sessions that will address: how ways of invading the nervous system vary between pathogens; what are the specific neural target cells and their receptors for neurotropic pathogens; what are the characteristics of the immune and neural responses to invading pathogens; how clinical and pathogenesis studies can elucidate the nature of the nervous system damage caused by different pathogens; what are the new prospects for therapies and diagnostic in some of the diseases covered. Another important objective of this conference is to attract young researchers from all continents in the field. Thes trainees will present posters and/or short oral presentations, giving them ample time to discuss their work with the experts. Success of this grant will be instrumental in providing this opportunity to younger researchers to participant and contribute, thus advancing the mission of NINDS by expanding the knowledge on clinical and pathogenesis of devastating neurological diseases, and promoting progress in their prevention, diagnostic and therapies.

 描述（由申请人提供）： 嗜神经性病原体引起的疾病负担通常导致神经系统后遗症，影响幸存者的运动、感觉器官和认知功能。这反过来又损害社会经济进步，特别是在这类疾病特别流行的热带地区。随着气候变化越来越多地影响我们的星球，昆虫媒介传播的病原体可能会转移到其他地区，这表明这些病原体如何对神经细胞功能产生如此深远的影响，导致致命的结果或使人衰弱的长期神经功能障碍。由于中枢神经系统通常不是感染的主要目标部位，因此存在干扰病原体传播的机会之窗。开发治疗神经系统疾病的方法至关重要，这些疾病会造成长期的疾病负担和对社会的影响。 关于“神经系统感染”的戈登研究会议是该系列的第二次会议，将促进该领域的知识，并促进资源丰富和贫困地区的医学研究中心之间的交流。GRC的形式（以社区为基础，小观众，专注于未发表的材料）是理想的创建一个多学科的对话，将涉及临床医生和科学家研究疾病机制和宿主遗传学，嗜神经性感染因子的分子构成，以及对嗜神经性病原体的先天性和适应性免疫反应。该系列将汇集著名的临床医生和科学家，他们研究全球人类神经系统感染的疾病表现和分子机制，这将进一步促进合作，加速诊断/预后工具和开创性疗法开发方面的研究。 建立一个由从事神经系统感染研究的顶级科学家组成的强大社区，将提高世界领先研究机构对该领域影响和挑战的认识，并促进该主题的新研究和培训计划。会议将以主题演讲开始，随后是科学会议，将讨论：病原体之间入侵神经系统的方式如何不同;嗜神经病原体的特定神经靶细胞及其受体是什么;入侵病原体的免疫和神经反应的特征是什么;临床和发病机制研究如何阐明不同病原体引起的神经系统损伤的性质;在所涉及的一些疾病中，治疗和诊断的新前景是什么？这次会议的另一个重要目标是吸引来自各大洲的年轻研究人员。学员将展示海报和/或简短的口头介绍，以便有充分的时间与专家讨论他们的工作。这项资助的成功将有助于为年轻的研究人员提供参与和贡献的机会，从而通过扩大对破坏性神经系统疾病的临床和发病机制的知识，促进其预防，诊断和治疗的进展，推进NINDS的使命。