Experimental Cutaneous Pathology Core

实验皮肤病理核心（ECPC）的总体目标是通过为UWSDRC成员提供精心处理的正常和患病人体皮肤样本，以及人类和动物皮肤形态学分析的专业知识，以经济有效的方式促进皮肤研究。杰克·朗利博士（ECPC主任）指导华盛顿大学皮肤病理学实验室，该实验室与主要的莫氏外科实验室整合。这些实验室与由Gary Wood博士（UWSDRC主任和ECPC联合主任）领导的UW皮肤病免疫诊断实验室在功能上集成。Longley博士持有IRB协议，允许从所有三个实验室提供去识别的正常和病变，石蜡包埋和冷冻人体皮肤，用于可行性或原理研究证明，而无需单独的IRB批准。ECPC的资金将通过1)院长和院系的补充资金；2)提供新装修的ECPC专用空间，与皮肤病学研究实验室和UWSDRC不断发展的技术和细胞培养核心相连；3)新的扩大的皮肤病理学实验室空间，包括由华盛顿大学医院提供的组织库冷冻室。ECPC将进一步利用华盛顿大学现有的几个核心设施的资源，其中最著名的是由ECPC联合主任Ruth Sullivan博士管理的动物实验病理学实验室（EPL）。通过EPL， ECPC将提供对动物皮肤常规和先进技术具有经验和特殊兴趣的技术人员的样品处理。Longley博士和Sullivan博士将共同为实验动物皮肤提供咨询和诊断解释，重点是啮齿动物皮肤。ECPC将为UWSDRC的研究人员提供具有成本效益的相关设备和所有这些服务，并将使用机构匹配资金购买最先进的inForm软件和现场定量研究培训，同时使用多光谱明亮场和荧光显微镜。ECPC将促进先进多核心技术的发展、思想交流和SDRC研究人员之间的合作，为与皮肤病病理学相关的互动和资源共享提供一个集中的中心。

The overall goal of the Experimental Cutaneous Pathology Core (ECPC) is to promote cutaneous research by providing UWSDRC members with carefully processed normal and diseased human skin samples, and expertise for morphologic analysis of human and animal skin, in a cost effective manner. Dr. Jack Longley (the ECPC Director) directs the UW Dermatopathology Laboratory, which is integrated with the main Mohs Surgical Laboratory. These labs are functionally integrated with the UW Dermatology lmmunodiagnostics Laboratory, directed by Dr. Gary Wood (UWSDRC Director and ECPC Co-Director). Dr. Longley holds an IRB protocol allowing provision of de-identified normal and diseased, paraffin embedded and frozen human skin from all three laboratories for feasibility or proof of principle studies without the need for separate IRB approval. ECPC funding will be leveraged by 1) supplemental funds from the Dean and department; 2) the provision of newly renovated dedicated ECPC space contiguous with the Dermatology research labs and the UWSDRC Evolving Technology and Cell Culture Cores; and 3) new enlarged Dermatopathology Laboratory space including freezers for tissue banking provided by the UW Hospital. The ECPC will further leverage resources with several existing UW core facilities, most notably the animal Experimental Pathology Lab (EPL) managed by Dr. Ruth Sullivan, also an ECPC Co-Director. Through the EPL, the ECPC will provide sample processing by technicians with experience and special interest in routine and advanced techniques for animal skin. Together, Dr. Longley and Dr. Sullivan will provide consultation and diagnostic interpretation for experimental animal skin with an emphasis on rodent skin. The ECPC will provide UWSDRC researchers with cost effective access to and assistance with relevant equipment and all these services, and will use institutional matching funds to acquire state-of-the-art inForm software and training for in situ quantitative studies, simultaneously using multi-spectral bright field and fluorescence microscopy. The ECPC will foster the development of advanced multi-core techniques, the exchange of ideas, and collaborations among SDRC researchers by providing a centralized hub for interactions and sharing of resources related to the pathology of skin disease.