Experimental Cutaneous Pathology Core

实验皮肤病理学核心

基本信息

批准号：
8926360
负责人：
B Jack Longley
金额：
$ 8.51万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8926360
关键词：
Advanced Development Age Anatomy Animals Cell Culture Techniques Collaborations Communities Complex Computer software Consultations Core Facility Cutaneous Dermatology Dermatopathology Diagnostic Economics Equipment Ethnic Origin Experimental Pathology Feasibility Studies Fluorescence Fluorescence Microscopy Fostering Freezing Funding Gender Gene Expression Goals Hand Histologic Hospitals Human Image In Situ Institutional Review Boards Laboratories Microscopic Molecular Morbidity - disease rate Morphology Operative Surgical Procedures Organ Paraffin Embedding Pathology Population Preparation Process Protocols documentation Research Research Personnel Resource Sharing Resources Rodent Sampling Services Skin Specimen Techniques Technology Tissue Banking Tissue Banks Training Universities Wisconsin Wood material Work cost effective experience instrumentation interest member mortality skin disorder socioeconomics

项目摘要

The overall goal of the Experimental Cutaneous Pathology Core (ECPC) is to promote cutaneous research by providing UWSDRC members with carefully processed normal and diseased human skin samples, and expertise for morphologic analysis of human and animal skin, in a cost effective manner. Dr. Jack Longley (the ECPC Director) directs the UW Dermatopathology Laboratory, which is integrated with the main Mohs Surgical Laboratory. These labs are functionally integrated with the UW Dermatology lmmunodiagnostics Laboratory, directed by Dr. Gary Wood (UWSDRC Director and ECPC Co-Director). Dr. Longley holds an IRB protocol allowing provision of de-identified normal and diseased, paraffin embedded and frozen human skin from all three laboratories for feasibility or proof of principle studies without the need for separate IRB approval. ECPC funding will be leveraged by 1) supplemental funds from the Dean and department; 2) the provision of newly renovated dedicated ECPC space contiguous with the Dermatology research labs and the UWSDRC Evolving Technology and Cell Culture Cores; and 3) new enlarged Dermatopathology Laboratory space including freezers for tissue banking provided by the UW Hospital. The ECPC will further leverage resources with several existing UW core facilities, most notably the animal Experimental Pathology Lab (EPL) managed by Dr. Ruth Sullivan, also an ECPC Co-Director. Through the EPL, the ECPC will provide sample processing by technicians with experience and special interest in routine and advanced techniques for animal skin. Together, Dr. Longley and Dr. Sullivan will provide consultation and diagnostic interpretation for experimental animal skin with an emphasis on rodent skin. The ECPC will provide UWSDRC researchers with cost effective access to and assistance with relevant equipment and all these services, and will use institutional matching funds to acquire state-of-the-art inForm software and training for in situ quantitative studies, simultaneously using multi-spectral bright field and fluorescence microscopy. The ECPC will foster the development of advanced multi-core techniques, the exchange of ideas, and collaborations among SDRC researchers by providing a centralized hub for interactions and sharing of resources related to the pathology of skin disease.

实验性皮肤病理学核心（ECPC）的总体目标是通过为UWSDRC成员提供精心处理的正常和患病的人皮肤样本，并以成本效益的方式为人类和动物皮肤的形态分析提供专业知识。杰克·朗利（Jack Longley）（ECPC主任）指挥UW皮肤病理学实验室，该实验室与主要MOHS手术实验室集成在一起。这些实验室在功能上与UW皮肤病学LMMUNOD诊断实验室（UWSDRC主管兼ECPC联合导演）指导的UW皮肤病学LMMUNODIANODNOSTICS实验室。 Longley博士持有IRB方案，允许提供从所有三个实验室中提供去识别的正常和患病，石蜡嵌入和冷冻的人类皮肤，以提供可行性或原则研究证明，而无需单独批准IRB。 ECPC的资金将由1）院长和部门的补充资金杠杆化； 2）提供与皮肤科研究实验室和UWSDRC不断发展的技术和细胞培养核的新近翻新的专用ECPC空间相连； 3）新的扩大的皮肤病理学实验室空间，包括UW医院提供的组织库的冰柜。 ECPC将通过几个现有的UW核心设施进一步利用资源，最著名的是由ECPC共同导演Ruth Sullivan博士管理的动物实验病理实验室（EPL）。通过EPL，ECPC将为技术人员提供对动物皮肤常规和先进技术的特殊兴趣的样品处理。 Longley博士和Sullivan博士一起将为实验性动物皮肤提供咨询和诊断解释，重点是啮齿动物皮肤。 ECPC将为UWSDRC研究人员提供具有成本效益的相关设备和所有这些服务的帮助，并将使用机构匹配的资金来获取最先进的信息软件和培训，以同时使用多光谱的明亮领域和荧光显微镜，同时使用原位数量研究。 ECPC将通过为SDRC研究人员之间的高级多核技术，思想的交流以及合作的开发，通过为相互作用和共享与皮肤病病理学相关的资源提供集中式枢纽。