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Experimental Cutaneous Pathology Core

实验皮肤病理学核心

基本信息

批准号：
9135131
负责人：
B Jack Longley
金额：
$ 25.66万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9135131
关键词：
Advanced Development Age Anatomy Animals Cell Culture Techniques Collaborations Communities Complex Computer software Consultations Core Facility Cutaneous Dermatology Dermatopathology Diagnostic Economics Equipment Ethnic Origin Experimental Pathology Feasibility Studies Fluorescence Fluorescence Microscopy Fostering Freezing Funding Gender Gene Expression Goals Hand Histologic Hospitals Human Image In Situ Institutional Review Boards Laboratories Microscopic Molecular Morbidity - disease rate Morphology Operative Surgical Procedures Organ Paraffin Embedding Pathology Population Preparation Process Protocols documentation Research Research Personnel Resource Sharing Resources Rodent Sampling Services Skin Specimen Techniques Technology Tissue Banking Tissue Banks Training Universities Wisconsin Wood material Work cost effective experience instrumentation interest member mortality skin barrier skin disorder socioeconomics

项目摘要

The overall goal of the Experimental Cutaneous Pathology Core (ECPC) is to promote cutaneous research by providing UWSDRC members with carefully processed normal and diseased human skin samples, and expertise for morphologic analysis of human and animal skin, in a cost effective manner. Dr. Jack Longley (the ECPC Director) directs the UW Dermatopathology Laboratory, which is integrated with the main Mohs Surgical Laboratory. These labs are functionally integrated with the UW Dermatology lmmunodiagnostics Laboratory, directed by Dr. Gary Wood (UWSDRC Director and ECPC Co-Director). Dr. Longley holds an IRB protocol allowing provision of de-identified normal and diseased, paraffin embedded and frozen human skin from all three laboratories for feasibility or proof of principle studies without the need for separate IRB approval. ECPC funding will be leveraged by 1) supplemental funds from the Dean and department; 2) the provision of newly renovated dedicated ECPC space contiguous with the Dermatology research labs and the UWSDRC Evolving Technology and Cell Culture Cores; and 3) new enlarged Dermatopathology Laboratory space including freezers for tissue banking provided by the UW Hospital. The ECPC will further leverage resources with several existing UW core facilities, most notably the animal Experimental Pathology Lab (EPL) managed by Dr. Ruth Sullivan, also an ECPC Co-Director. Through the EPL, the ECPC will provide sample processing by technicians with experience and special interest in routine and advanced techniques for animal skin. Together, Dr. Longley and Dr. Sullivan will provide consultation and diagnostic interpretation for experimental animal skin with an emphasis on rodent skin. The ECPC will provide UWSDRC researchers with cost effective access to and assistance with relevant equipment and all these services, and will use institutional matching funds to acquire state-of-the-art inForm software and training for in situ quantitative studies, simultaneously using multi-spectral bright field and fluorescence microscopy. The ECPC will foster the development of advanced multi-core techniques, the exchange of ideas, and collaborations among SDRC researchers by providing a centralized hub for interactions and sharing of resources related to the pathology of skin disease.

实验皮肤病理学核心（ECPC）的总体目标是通过以具有成本效益的方式为UWSDRC成员提供精心处理的正常和患病人类皮肤样本以及人类和动物皮肤形态分析的专业知识来促进皮肤研究。Jack Longley博士（ECPC主任）指导UW皮肤病理学实验室，该实验室与主要的Mohs外科实验室相结合。这些实验室在功能上与UW皮肤免疫诊断实验室整合，由加里伍德博士（UWSDRC主任和ECPC联合主任）指导。Longley博士持有IRB方案，允许提供来自所有三个实验室的去识别的正常和患病、石蜡包埋和冷冻人皮肤，用于可行性或原理研究证明，而无需单独的IRB批准。ECPC资金将通过1）院长和部门的补充资金来利用; 2）提供新装修的专用ECPC空间，与皮肤病学研究实验室和UWSDRC不断发展的技术和细胞培养核心相邻;和3）新扩大的皮肤病理学实验室空间，包括UW医院提供的组织库冷冻机。ECPC将进一步利用现有的几个UW核心设施的资源，最值得注意的是由Ruth Sullivan博士管理的动物实验病理学实验室（EPL），也是ECPC的联合主任。通过EPL，ECPC将提供样品处理技术人员的经验和特殊兴趣，在常规和先进的技术，动物皮肤。Longley博士和Sullivan博士将共同为实验动物皮肤提供咨询和诊断解释，重点是啮齿动物皮肤。ECPC将为UWSDRC研究人员提供具有成本效益的相关设备和所有这些服务的访问和援助，并将使用机构匹配资金来获得最先进的inForm软件和原位定量研究培训，同时使用多光谱明场和荧光显微镜。ECPC将通过提供与皮肤病病理学相关的资源交互和共享的集中中心，促进SDRC研究人员之间的先进多核技术的开发、思想交流和合作。