Metabolism, Aging, Pathogenesis, Stress and Small RNAs Meeting

项目总结 传统的生物医学研究以个体衰老相关疾病的病因学为目标。然而，慢性病 在老年很少是孤立的，因此，即使在针对疾病的治疗方面取得了巨大的进步，也会有 对延长无病年限的影响最小。另一种可能有更大回报的替代方案是 关注他们共同的风险因素，年龄的增加，以了解年轻状态的丧失是如何导致 疾病风险增加。2020年线虫的代谢、衰老、致病、应激和小RNA (MAPS 2020)是一年两次的会议，传统上聚集研究不同领域的领先研究人员 单个模式生物体中衰老生物学的各个方面。MAP 2020将利用这一优势，并(I)提供 展示主要未发表的前沿发现的平台--从已建立的时代起 和新的调查人员，(Ii)通过以下方式扩大该领域的视野并鼓励开箱即用的思维 在每届会议中纳入新的主题和各种创新的形式，(三)提供机会 对于博士后和研究生实习生，特别是妇女和代表性不足的少数群体(URM) 介绍他们的研究，(Iv)为新的教员实习生提供互动、指导和网络，以及 通过引入两项举措建立了师资队伍。 到目前为止，2020年的会议名单包括来自42个知名 科学家(15名女性(38%)，5名国际科学家)。在确认的11位会议主席中，有7位是后起之秀女性 在老龄化研究中(%)。2020年会议日程表包含鼓励我们声明的格式 强调提拔新的调查人员和受训人员。大多数受邀者(72%；37/52)没有 在过去四年的这次会议上发言，其中超过三分之一(21/52)被邀请 这是第一次举行这次会议。会议日程旨在提高以下项目的交叉参与度和知名度 新教师、博士后实习生和研究生。我们包括两项创新举措：一是战略 青年教师与资深科学家的结对指导倡议，以及老年科学的前沿概念 主动将新概念和开箱即用的概念引入老龄化研究。 通过这项申请，我们正在申请资金，以支持被邀请的演讲者出席，因为 以及处于不同职业阶段的研究人员，从研究生、博士后到新独立的 教职员工，他们将参加会议。我们建议从这笔赠款中拨出55%的资金 特别是为了支持女科学家和URM的出席。我们计划提供现场托儿服务， 出席会议的人员的旅费和住宿费，以方便年轻科学家和有家属的人参与 委员会建议缔约国履行其职责，并使会议完全无障碍地向残疾人开放。

PROJECT SUMMARY Conventional biomedical research targets the etiology of individual aging-related diseases. Yet chronic diseases in old age rarely come in isolation, and thus, even dramatic advances in disease-specific treatments will have minimal impact on the extension of disease-free years. An alternative that is likely to have a far greater payoff is to focus on their common risk factor, increased age, to understand how loss of the youthful state leads to increased disease risk. The 2020 ‘C. elegans Metabolism, Aging, Pathogenesis, Stress and Small RNAs’ (MAPS 2020) is a bi-annual meeting that traditionally brings together leading researchers studying different aspects of aging biology in a single model organism. MAPS 2020 will leverage this strength and (i) provide a platform for presentation of predominantly unpublished, cutting edge-discoveries in aging from established and new investigators, (ii) expand the horizons of the field and encourage out-of-the-box thinking by incorporation of new topics and a variety of innovative formats in each session, (iii) provide opportunities for postdoc and graduate-student trainees, especially women and under-represented minorities (URMs) to present their research, (iv) facilitate interaction, mentoring and networking for new faculty trainees and established faculty through the introduction of two initiatives. The 2020 meeting roster thus far includes confirmed Invited speaker presentations from 42 renowned scientists (15 women (38%), 5 international). Seven out of the confirmed 11 session chairs are rising-star women in aging research (64%). The 2020 Conference Schedule incorporates formats that encourage our stated emphasis of promoting new investigators and trainees. The majority (72%; 37/52) of the invitees have not spoken at this meeting in the last four years, and amongst them, more than a third (21/52) are invitees to this meeting for the first time. The meeting schedule is designed to increase cross-participation and visibility of new faculty, post-doctoral trainees and graduate-students. We include two innovative initiatives: a strategic Paired-Mentoring Initiatives of young faculty with senior scientists, and a Cutting-Edge Concepts in Geroscience Initiative to bring new concepts and out-of-the-box concepts to aging research. Through this application, we are requesting funds to support the attendance of the invited speakers as well as the investigators at various career stages, from graduate students and post-docs to newly-independent faculty, who will be participating in the meeting. We propose allocating 55% of the funds from this grant specifically to support attendance of female scientists and URMs. We plan to offer on-site child-care services, travel and lodging to the meeting attendees to facilitate participation of young scientists and those with family responsibilities, and to make the meeting fully accessible to individuals with disabilities.