Metabolism, Aging, Pathogenesis, Stress and Small RNAs Meeting

项目摘要 传统的生物医学研究的目标是个体衰老相关疾病的病因。然而慢性疾病 在老年人中，很少是孤立出现的，因此，即使是在疾病特异性治疗方面的巨大进步， 对延长无病年的影响最小。另一种可能带来更大回报的选择是 关注他们共同的风险因素，年龄的增长，了解年轻状态的丧失如何导致 增加疾病风险。2020年C。线虫代谢、衰老、发病机制、应激与小RNA (MAPS 2020年）是一年两次的会议，传统上汇集了研究不同领域的领先研究人员。 衰老生物学的各个方面。MAPS 2020将利用这一优势，并（i）提供 平台，主要是未发表的，尖端发现老化从建立 和新的调查人员，（二）扩大视野的领域，并鼓励开箱即用的思维， 在每届会议上纳入新的专题和各种创新形式，㈢提供机会 为博士后和研究生学员，特别是妇女和代表性不足的少数民族（URM）， 提出他们的研究，（四）促进互动，指导和新的教师学员网络， 通过两项举措建立了教师队伍。 到目前为止，2020年的会议名册包括来自42位知名人士的确认特邀演讲者 科学家（15名妇女（38%），5名国际科学家）。在确认的11位会议主席中，有7位是冉冉升起的女性 老年研究（64%）。2020年会议日程包含了鼓励我们声明的格式 重点是促进新的调查员和受训人员。大多数（72%; 37/52）受邀者没有 在过去四年中，在这次会议上发言的人中，超过三分之一（21/52）是应邀参加会议的。 这是第一次见面。会议时间表旨在增加交叉参与和能见度， 新教师，博士后培训生和研究生。我们包括两项创新举措： 年轻教师与资深科学家的配对指导计划，以及老年科学的前沿概念 主动为老龄化研究带来新的概念和开箱即用的概念。 通过这一申请，我们要求资金支持受邀演讲者出席会议， 以及处于不同职业阶段的研究人员，从研究生和博士后到新独立的研究人员， 教师，谁将参加会议。我们建议从这笔赠款中拨出55%的资金 特别是支持女科学家和统一记录管理机构参加会议。我们计划提供上门托儿服务， 为与会者提供旅费和住宿，以便利青年科学家和有家人的科学家参加会议 会议的目的是履行职责，并使残疾人完全无障碍地参加会议。

PROJECT SUMMARY Conventional biomedical research targets the etiology of individual aging-related diseases. Yet chronic diseases in old age rarely come in isolation, and thus, even dramatic advances in disease-specific treatments will have minimal impact on the extension of disease-free years. An alternative that is likely to have a far greater payoff is to focus on their common risk factor, increased age, to understand how loss of the youthful state leads to increased disease risk. The 2020 ‘C. elegans Metabolism, Aging, Pathogenesis, Stress and Small RNAs’ (MAPS 2020) is a bi-annual meeting that traditionally brings together leading researchers studying different aspects of aging biology in a single model organism. MAPS 2020 will leverage this strength and (i) provide a platform for presentation of predominantly unpublished, cutting edge-discoveries in aging from established and new investigators, (ii) expand the horizons of the field and encourage out-of-the-box thinking by incorporation of new topics and a variety of innovative formats in each session, (iii) provide opportunities for postdoc and graduate-student trainees, especially women and under-represented minorities (URMs) to present their research, (iv) facilitate interaction, mentoring and networking for new faculty trainees and established faculty through the introduction of two initiatives. The 2020 meeting roster thus far includes confirmed Invited speaker presentations from 42 renowned scientists (15 women (38%), 5 international). Seven out of the confirmed 11 session chairs are rising-star women in aging research (64%). The 2020 Conference Schedule incorporates formats that encourage our stated emphasis of promoting new investigators and trainees. The majority (72%; 37/52) of the invitees have not spoken at this meeting in the last four years, and amongst them, more than a third (21/52) are invitees to this meeting for the first time. The meeting schedule is designed to increase cross-participation and visibility of new faculty, post-doctoral trainees and graduate-students. We include two innovative initiatives: a strategic Paired-Mentoring Initiatives of young faculty with senior scientists, and a Cutting-Edge Concepts in Geroscience Initiative to bring new concepts and out-of-the-box concepts to aging research. Through this application, we are requesting funds to support the attendance of the invited speakers as well as the investigators at various career stages, from graduate students and post-docs to newly-independent faculty, who will be participating in the meeting. We propose allocating 55% of the funds from this grant specifically to support attendance of female scientists and URMs. We plan to offer on-site child-care services, travel and lodging to the meeting attendees to facilitate participation of young scientists and those with family responsibilities, and to make the meeting fully accessible to individuals with disabilities.