P30 - CENTER CORE GRANT FOR VISION RESEARCH

P30 - 愿景研究中心核心拨款

• 批准号: 8689047
• 负责人: LINDA M ZANGWILL
• 金额: $ 74.29万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8689047
• 关键词: Address; Algorithms; Anatomy; Animal Model; Animal Structures; Animal Technicians; Animals; Applications Grants; Appointment; Area; Basic Science; Bioinformatics; Biological; Biological Markers; Biology; Biomedical Engineering; Biometry; Blood Vessels; California; Cancer Center Support Grant; Cellular biology; Center Core Grants; Clinical Research; Collaborations; Communities; Complex; Computational Science; Computer Analysis; Computers; Confocal Microscopy; Cornea; Data; Data Set; Descriptor; Development; Diabetic Retinopathy; Educational process of instructing; Electrophysiology (science); Engineering; Ensure; Environment; Epidemiology; Equipment; Eye; Eye diseases; Faculty; Family Practice; Fostering; Foundations; Functional Imaging; Funding; Future; Genetic; Genomics; Glaucoma; Goals; Health Sciences; High Performance Computing; Histology; Housing; Human; Human Resources; Image; Image Analysis; Immunohistochemistry; Individual; Information Technology; Institutes; Interdisciplinary Study; Laboratories; Laboratory Animals; Letters; Libraries; Life; Macular degeneration; Mathematics; Measurement; Medical; Medical Records; Medicine; Metadata; Methodology; Methods; Microscope; Molecular Biology; Neurosciences; Noise; Online Systems; Ophthalmology; Pathology; Pediatrics; Pharmacologic Substance; Prevention; Preventive Medicine; Process; Productivity; Psychology; Radiology Specialty; Reagent; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Resource Sharing; Resources; Retina; Retinal; Retinal Degeneration; Science; Scientist; Secure; Services; Statistical Models; Techniques; Telecommunications; Testing; Time; Tissues; Training; Travel; United States National Institutes of Health; Universities; Vision; Vision research; Work; animal care; animal facility; computer program; computer science; computing resources; cost; digital; eye center; fluorescence imaging; health science research; image processing; imaging modality; improved; innovation; insight; instrument; investigator training; light microscopy; meetings; professor; programs; ranpirnase; research study; restoration; square foot; supercomputer; tissue processing; tool

DESCRIPTION (provided by applicant): This University of California, San Diego (UCSD) Vision Research Core grant proposal will provide critical resources in 4 distinct substantive areas to leverage the expertise of NEI funded UCSD investigators and to accelerate discoveries from their NIH funded studies. 15 investigators have a total of 18 NEI funded eligible R01 projects. These investigators from the UCSD Departments of Ophthalmology, Pathology, Pediatrics, Institute for Genomic Medicine, Radiology, and Psychology represent an impressive, productive, and a collegial group of vision researchers. UCSD vision researchers encompass all levels of faculty appointments and research accomplishments, from 9 full professors who are leaders in their respective fields to 6 recently recruited junior faculty (Drs. Annese, Balasubramanian, Bosworth, Huberman, Ju, Lin). Moreover, the substantial funding from other NIH institutes and foundations (Table 2) further highlights the strength of UCSD's vision research program. In particular, our portfolio is strong in human and animal imaging and functional assessment, image analysis, epidemiology/clinical research, genetics, glaucoma, AMD, retinal degeneration, cell biology, molecular biology, animal models, and vascular biology. The UCSD Department of Ophthalmology has a long tradition of excellence in glaucoma and retina research. With the recent recruitment of seven additional NEI funded investigators (Drs. Ayyagari, La Spada, Lin, Ju, Zhang, and most recently Balasubramanian and Huberman), vision research at UCSD has reached a critical mass that will benefit from an infrastructure to coordinate, enhance and leverage the expertise of each participating investigator to benefit the entire UCSD vision research community. Currently, 9 NEI funded investigators have offices and laboratories in the adjacent and interconnected Shiley Eye Center (SEC), Hamilton Glaucoma Center (HGC) and Jacobs Retina Center (HRC). The two adjoining research centers (Hamilton Glaucoma Center and Jacobs Retina Center) comprise 26,000 sq ft of dedicated research and office space. The SEC also provides extensive computer/IT support, and independent medical record services, as well as houses an auditorium and library. Another 6 NEI-funded investigators have offices nearby (less than a 5 minute drive from the Dept of Ophthalmology) at the main UCSD campus and adjoining Health Sciences research complex. The main campus includes vision researchers from the Depts. of Psychology (Dr. MacLeod), Biology(Dr. Rainegel), Neuroscience (Dr. Huberman) and Bioengineering (Dr. Silva). The Health Sciences complex includes the Institute for Genomic Medicine, Skaggs Pharmaceutical Sciences Building (Drs. Zhang and La Spada), the Division of Biostatistics and Bioinformatics and Biostatistics Research Center (BRC) in the Department of Family and Preventive Medicine (Dr. Jain) and the Basic Science Building-BSB with adjoining Medical Teaching Facility-MTF which house the animal care facilities and animal laboratories of Drs. Lin, Ju, Freeman, Bartsch, and Weinreb. Moreover, the UCSD Vision Research Core will leverage the unique engineering and computational expertise of UCSD's Center for Computational Sciences, Mathematics, and Engineering¿CSME training initiative. Computer Science (Prof David Kriegman) and Math Department (Prof Michael Hoist - see letter of support), the California Institute of Telecommunications and Information Technology (CALIT2- whose mandate is to enhance the "collaborative research environment for the digital future" for details see http://www.calit2.net/) (Prof Larry Smarr- see letter of support), and the resources of the San Diego Supercomputer Center to enhance current research endeavors and extend existing collaborations (e.g., Glaucoma-Math-Calit2 collaboration) to the broader vision research community. The overall purpose of this application is to provide shared resources to enhance and accelerate the productivity of the vision research community at UCSD. The following 4 modules will provide important new resources and services that are currently unavailable or difficult for each investigator to obtain individually. Each module has either 2 Co-Directors (each with NEI ROI funding), or a Director and Assistant Director (with specific expertise valuable to the module) to ensure administrative coverage so that issues can be addressed in a timely manner regardless of travel or other commitments by one of the Directors. In addition, the personnel for each module will both provide direct services (e.g. statistical analyses, computer programming, histology) and also train investigators and their staff to complete tasks so that module resources are utilized as efficiently as possible for maximum productivity.

描述（由申请人提供）：加州大学圣地亚哥分校 (UCSD) 视觉研究核心拨款提案将在 4 个不同的实质性领域提供关键资源，以利用 NEI 资助的 UCSD 研究人员的专业知识，并加速 NIH 资助的研究的发现。 15名研究者共有18个NEI资助的符合条件的R01项目。这些来自加州大学圣地亚哥分校眼科、病理学、儿科、基因组医学研究所、放射学和心理学系的研究人员代表了一支令人印象深刻、富有成效的、团结的视觉研究人员团队。加州大学圣地亚哥分校的愿景研究人员涵盖了各个级别的教职人员任命和研究成就，从 9 位在各自领域处于领先地位的正教授到 6 位最近招募的初级教职人员（Annese、Balasubramanian、Bosworth、Huberman、Ju、Lin 博士）。此外，来自其他 NIH 研究所和基金会的大量资助（表 2）进一步凸显了 UCSD 视觉研究项目的实力。特别是，我们的产品组合在人类和动物成像和功能评估、图像分析、流行病学/临床研究、遗传学、青光眼、AMD、视网膜变性、细胞生物学、分子生物学、动物模型和血管生物学方面实力雄厚。 加州大学圣地亚哥分校眼科在青光眼和视网膜研究方面拥有悠久的卓越传统。随着最近招募了另外七名 NEI 资助的研究人员（Ayyagari 博士、La Spada、Lin、Ju、Zhang 博士以及最近的 Balasubramanian 和 Huberman），UCSD 的视觉研究已经达到了临界规模，这将受益于协调、增强和利用每个参与研究人员的专业知识的基础设施，从而使整个 UCSD 视觉研究社区受益。目前，9 名 NEI 资助的研究人员在相邻且相互连接的 Shiley 眼科中心 (SEC)、汉密尔顿青光眼中心 (HGC) 和 Jacobs 视网膜中心 (HRC) 设有办公室和实验室。两个毗邻的研究中心（汉密尔顿青光眼中心和雅各布斯视网膜中心）拥有 26,000 平方英尺的专用研究和办公空间。 SEC 还提供广泛的计算机/IT 支持和独立的医疗记录服务，并设有礼堂和图书馆。另外 6 名 NEI 资助的研究人员在 UCSD 主校区附近（距眼科不到 5 分钟车程）和毗邻的健康科学研究中心设有办公室。主校区包括来自各部门的视觉研究人员。心理学（MacLeod 博士）、生物学（Rainegel 博士）、神经科学（Huberman 博士）和生物工程（Silva 博士）。健康科学综合体包括基因组医学研究所、Skaggs 药物科学大楼（Zhang 博士和 La Spada 博士）、家庭和预防医学系生物统计和生物信息学部以及生物统计研究中心 (BRC)（Jain 博士）以及基础科学大楼 - BSB 以及毗邻的医学教学设施 - MTF，其中设有 Drs. 的动物护理设施和动物实验室。 Lin、Ju、Freeman、Bartsch 和 Weinreb。 此外，UCSD 视觉研究核心将利用 UCSD 计算科学、数学和工程中心 CSME 培训计划的独特工程和计算专业知识。计算机科学系（David Kriegman 教授）和数学系（Michael Hoist 教授 - 参见支持信）、加州电信和信息技术研究所 (CALIT2- 其任务是增强“数字未来的协作研究环境”，详细信息参见 http://www.calit2.net/)（Larry Smarr 教授 - 参见支持信）以及圣地亚哥超级计算机中心的资源，以增强当前的研究 努力并将现有合作（例如 Glaucoma-Math-Calit2 合作）扩展到更广泛的视觉研究界。 该应用程序的总体目的是提供共享资源，以提高和加速 UCSD 视觉研究社区的生产力。以下 4 个模块将提供目前每位研究者无法或难以单独获得的重要新资源和服务。每个模块都有 2 名联合主任（每名均获得 NEI ROI 资助），或一名主任和助理主任（具有对该模块有价值的特定专业知识），以确保行政覆盖范围，以便无论其中一名主任出差或做出其他承诺如何，都可以及时解决问题。此外，每个模块的人员将提供直接服务（例如统计分析、计算机编程、组织学），并培训研究人员及其工作人员完成任务，以便尽可能有效地利用模块资源，实现最大生产力。