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NEI Center Core Grant for Vision Research

NEI 中心视觉研究核心资助

基本信息

批准号：
10709400
负责人：
LINDA M ZANGWILL
金额：
$ 61.79万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2028-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10709400
关键词：
Acceleration Address Anatomy Animal Structures Animals Award Basic Science Biology Biometry Biostatistics Core California Center Core Grants Clinical Clinical Research Clustered Regularly Interspaced Short Palindromic Repeats Collaborations Communities Computer software Computers Core Grant Data Data Science Database Management Systems Dedications Dependovirus Diabetic Retinopathy Drug Screening Electronic Health Record Eligibility Determination Engineering Ensure Equipment Eye Eye diseases Faculty Family Fostering Functional Imaging Funding Future Genes Genomic medicine Glaucoma Goals Health Histology Human Human Resources Image Immunohistochemistry Individual Informatics Infrastructure Institution Interdisciplinary Study Lentivirus Vector Licensing Macular degeneration Microscopy Names National Eye Institute Neurosciences Ophthalmology Performance Pharmacology Prevention Process Production Productivity Psychology Research Research Personnel Resource Sharing Resources Schools Scientist Secure Services Techniques Tissues United States National Institutes of Health Universities Viral Vision Vision research biomedical imaging biomedical informatics cloud based computer science computing resources dimensional analysis high dimensionality histological specimens improved instrumentation programs research study service organization structural imaging tissue processing

项目摘要

SUMMARY Overall The overall purpose of the Center Core Grant for Vision Research is to provide core services and resources to enhance and accelerate the productivity and impact of the vision research community at the University of California, San Diego. Specifically, the Center Core Grant for Vision Research will leverage the outstanding basic science and clinical research expertise of National Eye Institute funded investigators by providing important resources and services organized into the following five distinct cores. 1. The Vision Biostatistics Core provides dedicated statistical expertise for the vision research community at UCSD. There are several common analysis themes and statistical issues that can be addressed effectively and efficiently by having a dedicated biostatistician familiar with eye research to analyze vision-related data and to ensure rigor and transparency of the results. 2. The Animal Structure and Function Core will provide shared instrumentation and a technician to assist with ocular structural imaging and functional imaging in animals. 3. The Computational Ophthalmology and Biomedical Informatics Core provides i) dedicated high- performance CPU and GPU computing resources ii) 3 computer programmers, iii) institutional software licenses, iv) electronic health record data extraction services, v) cloud-based data management infrastructure, and vi) secure file sharing and backup services to support UCSD’s cellular, animal and human vision research studies. 4. The Histology, Tissue Processing and High Content Microscopy Core provides rapid characterization of eye tissue with respect to histology, immunohistochemistry and high content microscopy for drug screening and histologic specimen imaging by supporting instrumentation and a technician who is familiar with ocular anatomy and techniques required to properly process ocular tissues. 5. The new Viral Production and CRISPR Engineering Core provides centralized dedicated space, equipment and personnel for the production, isolation and titering of adeno-associated virus (AAV) and lentivirus (LV) vectors and assistance with non-viral CRISPR gene editing. These cores will improve the efficiency and productivity and impact of UCSD vision scientists by providing core services that are unavailable or not easily accessible to individual investigators. The core grant infrastructure and resources also leverage the expertise of each participating investigator to enhance multidisciplinary collaboration for the benefit of the entire UCSD vision research community.

总结

项目成果

期刊论文数量（147）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

A Portable Platform for Evaluation of Visual Performance in Glaucoma Patients.

用于评估青光眼患者视觉表现的便携式平台。

DOI：
10.1371/journal.pone.0139426
发表时间：
2015
期刊：
PloS one
影响因子：
3.7
作者：
Rosen,PeterN;Boer,ErwinR;Gracitelli,CarolinaPB;Abe,RicardoY;Diniz-Filho,Alberto;Marvasti,AmirH;Medeiros,FelipeA
通讯作者：
Medeiros,FelipeA

Acute Rabbit Eye Model for Testing Subretinal Prostheses.

用于测试视网膜下假体的急性兔眼模型。

DOI：
10.1167/tvst.8.5.20
发表时间：
2019
期刊：
Translational vision science & technology
影响因子：
3
作者：
Xiao,Ying;Wang,Yuqin;Li,Fangting;Lin,Tiezhu;Huffman,Kristyn;Landeros,Stephanie;Bosse,Brandon;Jing,Yi;Bartsch,Dirk-Uwe;Thorogood,Scott;Freeman,WilliamR;Cheng,Lingyun
通讯作者：
Cheng,Lingyun

Microperimetry Findings in Pentosan Polysulfate Maculopathy.

戊聚糖多硫酸盐黄斑病的微视野检查结果。

DOI：
10.1016/j.oret.2023.08.009
发表时间：
2023
期刊：
Ophthalmology. Retina
影响因子：
0
作者：
Most,Jesse;Kalaw,FritzGeraldP;Walker,Evan;Arias,JuanD;Charng,Jason;Baxter,SallyL;Nudleman,Eric;Ferreyra,Henry;Freeman,WilliamR;Chen,FredK;Borooah,Shyamanga
通讯作者：
Borooah,Shyamanga

Dry Eye Symptom Severity and Visual Field Reliability Metrics.