OCT in the Ocular Hypertension Treatment Study: 20 Year Follow-up

项目摘要 “高眼压治疗研究（OHTS 3）：20年随访（3期）”是 旨在确定原发性开角型青光眼（POAG）的发病率和严重程度， 长期的OHTS队列。并确定功能性疾病的频率和严重程度 与POAG相关的限制。此外，这一特征明确的队列具有精确的 由3名青光眼专家评估的POAG发生的日期/时间信息 终点委员会成员，以及关于自我报告的功能限制的广泛数据， 其参与者。光谱域光学相干断层扫描（OCT），现在的标准治疗 用于检测昏迷性结构损伤和变化， OHTS作为OHTS 3核心访视的一部分。 该二次数据分析提案的目的是分析OHTS 3 OCT 扫描并利用20年的OHTS数据，为如何最好地利用OCT提供指导 在青光眼的临床管理中。具体目标1将决定是否审查黄斑 与VF和RNFL的临床标准检查相比，扫描改善了POAG检测 扫描。随着越来越多地关注患者报告的结果作为治疗的关键指标 成功，在具体目标2中，我们将利用OHTS的广泛生活质量（QOL）调查 3，并在模型中包括OCT结构损伤，以预测POAG引起的功能限制。 最后，OHTS 3核心访视时受试者的中位年龄为73岁，具体目标3将 描述结构性损害及其决定因素在精确发生后10年和15年的特征， POAG，并将其与年龄相关的结构变化进行比较，这些老年受试者 发展POAG。

Project Summary The “Ocular Hypertension Treatment Study (OHTS 3): 20-year follow-up (Phase 3)” was designed to determine the incidence and severity of primary open angle glaucoma (POAG) in the longstanding OHTS cohort. and determine the frequency and severity of functional limitations associated with POAG. Moreover, this well-characterized cohort has precise information on the dates/timing of the development of POAG assessed by 3 glaucoma specialist endpoint committee members, as well as extensive data on self-reported functional limitations of its participants. Spectral domain optical coherence tomography (OCT), now the standard of care for detecting glaucomatous structural damage and change was included for the first time in OHTS as part of the OHTS 3 core visit. The objective of this secondary data analysis proposal is to analyze the OHTS 3 OCT scans and leverage the 20 years of OHTS data to provide guidance on how best to utilize OCT in the clinical management of glaucoma. Specific Aim 1 will determine whether review of macula scans improves POAG detection compared to the clinical standard review of VF and RNFL scans. With the increased focus on patient-reported outcomes as a key measure of treatment success, in Specific Aim 2 we will utilize the extensive quality of life (QOL) surveys from OHTS 3 and include OCT structural damage in models to predict functional limitations due to POAG. Finally, with a participant median age of 73 years at the OHTS 3 core visit, Specific Aim 3 will characterize structural damage and its determinants 10 and 15 years after the precise onset of POAG and compare it to age-related structural changes in these older subjects who did not develop POAG.