OCT in the Ocular Hypertension Treatment Study: 20 Year Follow-up

项目摘要 《眼压治疗研究(OHTS 3)：20年随访(3期)》是 旨在确定青光眼(POAG)的发病率和严重程度 OHTS的长期队列。并确定功能性疾病的频率和严重性 与POAG相关的限制。此外，这一特征良好的队列具有精确的 由3名青光眼专家评估的POAG发生日期/时间的信息 终端委员会成员，以及关于自我报告的功能限制的大量数据 它的参与者。光谱域光学相干层析成像(OCT)，现在的标准护理 用于检测青光眼结构损害和变化的信息首次包含在 OHTS是OHTS 3核心访问的一部分。 此二次数据分析建议的目标是分析OHTS 3月3日 扫描并利用OHTS 20年的数据，为如何最好地利用OCT提供指导 在青光眼的临床治疗中。具体目标1将决定是否复查黄斑 与室颤和RNFL的临床标准综述相比，扫描改善了POAG的检测 扫描。随着越来越多的关注患者报告的结果作为治疗的关键衡量标准 成功，在具体目标2中，我们将利用OHTS广泛的生活质量(QOL)调查 3.在模型中包括OCT结构损伤，以预测POAG造成的功能限制。 最后，在OHTS 3核心访问中参与者的中位年龄为73岁，具体目标3将 在疾病确切发生10年和15年后，表征结构损伤及其决定因素 POAG，并将其与年龄相关的结构变化进行比较 发展POAG。

Project Summary The “Ocular Hypertension Treatment Study (OHTS 3): 20-year follow-up (Phase 3)” was designed to determine the incidence and severity of primary open angle glaucoma (POAG) in the longstanding OHTS cohort. and determine the frequency and severity of functional limitations associated with POAG. Moreover, this well-characterized cohort has precise information on the dates/timing of the development of POAG assessed by 3 glaucoma specialist endpoint committee members, as well as extensive data on self-reported functional limitations of its participants. Spectral domain optical coherence tomography (OCT), now the standard of care for detecting glaucomatous structural damage and change was included for the first time in OHTS as part of the OHTS 3 core visit. The objective of this secondary data analysis proposal is to analyze the OHTS 3 OCT scans and leverage the 20 years of OHTS data to provide guidance on how best to utilize OCT in the clinical management of glaucoma. Specific Aim 1 will determine whether review of macula scans improves POAG detection compared to the clinical standard review of VF and RNFL scans. With the increased focus on patient-reported outcomes as a key measure of treatment success, in Specific Aim 2 we will utilize the extensive quality of life (QOL) surveys from OHTS 3 and include OCT structural damage in models to predict functional limitations due to POAG. Finally, with a participant median age of 73 years at the OHTS 3 core visit, Specific Aim 3 will characterize structural damage and its determinants 10 and 15 years after the precise onset of POAG and compare it to age-related structural changes in these older subjects who did not develop POAG.