Genetic Mapping Resources for Common Mammalian Diseases

常见哺乳动物疾病的基因图谱资源

基本信息

  • 批准号:
    8984363
  • 负责人:
  • 金额:
    $ 15.57万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2001
  • 资助国家:
    美国
  • 起止时间:
    2001-04-01 至 2016-01-31
  • 项目状态:
    已结题

项目摘要

See instructions): Companion animals have many heritable diseases found in humans; many do not have a mouse model counterpart. To bridge the gap between human and mouse biology, genome projects have been initiated for companion animals, particularly for the cat and the dog; however, the initiative for the cat is still insufficient. A biologically focused genome initiative for the cat would span the gap between mouse and man more efficiently. A focused gene mapping approach would remedy the smaller scale of the cat genome project and allow the genomes of companion animals to unlock their biological secrets for human health and scientific advancement, providing invaluable tools and resources to researchers throughout the world. Our long-range goal is to use knowledge of genetic diseases in companion animals, particularly the cat, to gain insight into the pathogenesis of comparable diseases in man. The objective of this application is to improve the genetic resources for the domestic cat by three different research areas. This focus will provide resources and facilitate the research in humans and companion animal investigators who have interest in particular biological processes, simple or complex traits and inherited or acquired diseases. We will accomplish this task through three specific aims: 1) Develop a well-defined genetic map of the cat using^a focused approach of mapping 500 microsatellites and -15,000 SNPs that are associated with disease causing genes, that fill areas of poor marker coverage and that define evolutionary breakpoints on the chromosomes. 2) Aggressively identify new models and augment current feline models of human disease through the animal hospital services at the DC Davis Veterinary Medicine Teaching Hospital. 3) Develop a cat phenotypic and health information registry that will collect cat health data and provide DMA resources for the same cats. The project is relevant as it will generate genetic resources and models focusing on diseases that are difficult to study in humans, therefore, human health will rapidly benefit from the biology of companion animals. Researchers studying these diseases in animals and humans will have a leap in resources, including markers, DNA and patients. The proposed research is significant because it will provide sufficient resources for single gene studies, and begin the collection of markers, DNA, and animals for complex disease studies, such as asthma, cardiac disease, diabetes, infectious disease susceptibility and obesity. RELEVANCE (See instructions): The cat lifestyle has evolved to be sedentary and indoor, mimicking humans and associated health issues such as diabetes, obesity, and asthma. The proposed resource development will augment research for feline models of human disease, support clinical and laboratory based research and teaching within the veterinary community, and support the development of grant applications to funding agencies and the NIH.
参见说明): 伴侣动物有许多在人类身上发现的遗传性疾病;许多没有小鼠模型 对应物。为了弥合人类和小鼠生物学之间的差距,已经启动了基因组计划, 伴侣动物,特别是猫和狗;然而,猫的主动性仍然不足。 一个以生物学为重点的猫基因组计划将跨越老鼠和人类之间的差距, 有效地一个集中的基因定位方法将弥补猫基因组计划的小规模 并允许伴侣动物的基因组解开它们对人类健康的生物学秘密, 科学进步,为世界各地的研究人员提供宝贵的工具和资源。我们 长期目标是利用伴侣动物(特别是猫)遗传疾病的知识来获得 深入了解人类类似疾病的发病机制。本申请的目的是提高 家猫的遗传资源分为三个不同的研究领域。这一重点将提供 资源,并促进人类和伴侣动物研究人员的研究, 特定的生物过程、简单或复杂的性状以及遗传或获得性疾病。我们将 通过三个具体目标完成这项任务:1)使用^a开发一个定义明确的猫遗传图谱 一种定位500个微卫星和15,000个与疾病相关的SNP的集中方法, 导致基因,填补了标记覆盖率差的区域,并定义了基因组上的进化断点。 染色体2)积极识别新的模型并增强当前人类疾病的猫科动物模型 通过DC戴维斯兽医教学医院的动物医院服务。3)开发一个 猫表型和健康信息登记处,将收集猫的健康数据,并提供DMA资源, 同样的猫。该项目具有相关性,因为它将产生以疾病为重点的遗传资源和模型 因此,人类健康将迅速受益于生物学, 伴侣动物在动物和人类中研究这些疾病的研究人员将在以下方面取得飞跃: 资源,包括标记物、DNA和患者。这项研究意义重大,因为它将提供 为单基因研究提供足够的资源,并开始收集标记、DNA和动物, 复杂疾病研究,如哮喘、心脏病、糖尿病、传染病易感性和 肥胖 相关性(参见说明): 猫的生活方式已经演变成久坐和室内,模仿人类和相关的健康问题 如糖尿病、肥胖症和哮喘。拟议的资源开发将加强以下方面的研究: 人类疾病的猫模型,支持临床和实验室为基础的研究和教学内, 兽医界,并支持开发向资助机构和NIH的拨款申请。

项目成果

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LESLIE A LYONS其他文献

LESLIE A LYONS的其他文献

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{{ truncateString('LESLIE A LYONS', 18)}}的其他基金

Genetic components influencing the feline - human social bond
影响猫科动物与人类社会关系的遗传成分
  • 批准号:
    8129517
  • 财政年份:
    2010
  • 资助金额:
    $ 15.57万
  • 项目类别:
GENETIC RESOURCES FOR NON-HUMAN PRIMATES
非人类灵长类动物的遗传资源
  • 批准号:
    8172538
  • 财政年份:
    2010
  • 资助金额:
    $ 15.57万
  • 项目类别:
Genetic components influencing the feline - human social bond
影响猫科动物与人类社会关系的遗传成分
  • 批准号:
    7993031
  • 财政年份:
    2010
  • 资助金额:
    $ 15.57万
  • 项目类别:
GENETIC RESOURCES FOR NON-HUMAN PRIMATES
非人类灵长类动物的遗传资源
  • 批准号:
    7959026
  • 财政年份:
    2009
  • 资助金额:
    $ 15.57万
  • 项目类别:
GENETIC RESOURCES FOR NON-HUMAN PRIMATES
非人类灵长类动物的遗传资源
  • 批准号:
    7715620
  • 财政年份:
    2008
  • 资助金额:
    $ 15.57万
  • 项目类别:
GENETIC RESOURCES FOR NON-HUMAN PRIMATES
非人类灵长类动物的遗传资源
  • 批准号:
    7562214
  • 财政年份:
    2007
  • 资助金额:
    $ 15.57万
  • 项目类别:
GENETIC RESOURCES FOR NON-HUMAN PRIMATES
非人类灵长类动物的遗传资源
  • 批准号:
    7349727
  • 财政年份:
    2006
  • 资助金额:
    $ 15.57万
  • 项目类别:
GENETIC RESOURCES FOR NON-HUMAN PRIMATES
非人类灵长类动物的遗传资源
  • 批准号:
    6971476
  • 财政年份:
    2004
  • 资助金额:
    $ 15.57万
  • 项目类别:
GENETIC RESOURCES FOR NON-HUMAN PRIMATES
非人类灵长类动物的遗传资源
  • 批准号:
    6931523
  • 财政年份:
    2003
  • 资助金额:
    $ 15.57万
  • 项目类别:
Feline Model of an Inherited Craniofacial Abnormality
遗传性颅面异常的猫科动物模型
  • 批准号:
    6587474
  • 财政年份:
    2003
  • 资助金额:
    $ 15.57万
  • 项目类别:

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