The Ohio State University Neurological Emergencies Treatment Trials (OSU NETT) N*

描述(由申请人提供)：本提案是对2011年申请PAR-11-342神经急症治疗试验(NETT)网络临床站点中心的请求的回应。本文总结了俄亥俄州立大学NETT网络(OSUNETT)的能力：1)开发一个可靠的、经济高效的基础设施，可以快速有效地实施儿科和成人急性神经临床试验；2)快速识别、积极招募、高效招生以及有效维护和保留 每项临床研究的必要研究参与者；3)协调网络中多个发言人的参与，确保试验中所有参与者的安全和权利；4)与网络成员合作开发和测试创新的远程医疗方法，以加强知情的试验同意过程和患者随访；5)将NETT倡议和计划作为培训初级教师和研究协调员的主要组成部分，以适当设计和进行急性神经临床试验；以及5)将NETT倡议和计划用作培训初级教师和研究协调员的主要组成部分 与其他NETT中心合作，促进将研究成果转移到社区医院和急诊医生的临床实践中。OSUNETT代表了一个由急诊医生、神经强化专科医生、儿科医生、神经科医生、神经外科医生和创伤外科医生组成的多学科小组。这项建议建立在现有的研究基础设施的基础上，该基础设施支持在急诊科和医院外环境中使用知情同意豁免的急性神经临床试验。欧空局拥有完善的中心辐射式电话卒中基础设施，有14个轮辐，共同实现欧空局的目标。OSUNETT的集水区覆盖了几个县，有300多万俄亥俄州居民和每年900,000多名ED访问者。5个I级创伤中心和6个初级卒中中心为OSUNETT提供支持。欧空委拥有作为这一重要网络的有力参与者的经验、记录和坚实的基础设施的支持。

DESCRIPTION (provided by applicant): This proposal is in response to Request for Applications PAR-11-342 Neurological Emergencies Treatment Trials (NETT) Network Clinical Site Hubs for year 2011. This abstract summarizes the capability of the Ohio State University NETT network (OSUNETT) to: 1) develop a solid, cost-effective infrastructure that can quickly and efficiently implements both pediatric and adult acute neurological clinical trials; 2) To identify quickly, recruit aggressively, enroll efficiently and maintain and retain effectively the necessary study participants for each clinical study; 3) To coordinate the participation of multipl spokes in the network and ensure the safety and rights of all participants in the trials; 4) To collaborate with network members in developing and testing innovative telemedicine approaches to enhance informed trial consent process and patients follow-up; 5) To use the NETT initiatives and programs as a major component in training junior faculty, and research coordinators in the appropriate design and conduct of acute neurological clinical trials; and 5) To cooperate with other NETT Hubs in facilitating the transfer of research results to clinical practic in community hospital settings and among emergency medicine physicians. OSUNETT represents a multidisciplinary group of emergency physicians, neurointensivisits, pediatricians, neurologists, neurosurgeons, and trauma surgeons. This proposal builds on an existing research infrastructure that has supported acute neurological clinical trials both in the Emergency Department and in out-of-hospital setting using exemption from informed consent. OSUNETT has a well-established strong Hub-Spoke telestroke infrastructure with 14 spokes collaborating towards OSUNETT goals. The catchment area of OSUNETT extends over several counties with access to more than 3 million Ohio residents and more than 900,000 annual ED visits. OSUNETT is supported by 5 Level I Trauma Centers and 6 Primary Stroke Centers. OSUNETT has the experience, track record, and the support of a solid infrastructure to serve as strong participant in this important network.