The Ohio State University Neurological Emergencies Treatment Trials (OSU NETT) N*

俄亥俄州立大学神经紧急情况治疗试验 (OSU NTT) N*

• 批准号: 8856675
• 负责人: Michel T Torbey
• 金额: $ 29.02万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8856675
• 关键词: Academic Medical Centers; Accident and Emergency department; Acute; Adult; Brain; Catchment Area; Childhood; Clinical; Clinical Research; Clinical Trials; Clinical Trials Network; Collaborations; Communities; Community Healthcare; Community Hospitals; Consent; Contracts; County; Data; Early Intervention; Emergency Department Physician; Emergency Medicine; Emergency Situation; Emergency department visit; Emergency treatment; Enrollment; Ensure; Faculty; Foundations; Future; Goals; Health; Health Personnel; Healthcare; Hospitals; Hour; Informed Consent; Institution; Institutional Review Boards; Leadership; Morbidity - disease rate; National Institute of Neurological Disorders and Stroke; Neurologic; Neurological emergencies; Neurologist; Neurosciences; Neurosurgeon; Ohio; Outcome; Participant; Patients; Pediatric Hospitals; Physicians; Principal Investigator; Process; Protocols documentation; Recruitment Activity; Request for Applications; Research; Research Infrastructure; Research Personnel; Research Support; Rights; Safety; Site; Solid; Stroke; Structure; Surgeon; Telemedicine; Testing; Therapeutic; Time; Training; Training Activity; Trauma; Universities; abstracting; clinical practice; clinical research site; cost effective; design; dissemination research; experience; follow-up; human subject protection; improved; innovation; interest; member; mortality; multidisciplinary; pediatrician; programs; relating to nervous system; response; trauma centers; treatment trial

DESCRIPTION (provided by applicant): This proposal is in response to Request for Applications PAR-11-342 Neurological Emergencies Treatment Trials (NETT) Network Clinical Site Hubs for year 2011. This abstract summarizes the capability of the Ohio State University NETT network (OSUNETT) to: 1) develop a solid, cost-effective infrastructure that can quickly and efficiently implements both pediatric and adult acute neurological clinical trials; 2) To identify quickly, recruit aggressively, enroll efficiently and maintain and retain effectively the necessary study participants for each clinical study; 3) To coordinate the participation of multipl spokes in the network and ensure the safety and rights of all participants in the trials; 4) To collaborate with network members in developing and testing innovative telemedicine approaches to enhance informed trial consent process and patients follow-up; 5) To use the NETT initiatives and programs as a major component in training junior faculty, and research coordinators in the appropriate design and conduct of acute neurological clinical trials; and 5) To cooperate with other NETT Hubs in facilitating the transfer of research results to clinical practic in community hospital settings and among emergency medicine physicians. OSUNETT represents a multidisciplinary group of emergency physicians, neurointensivisits, pediatricians, neurologists, neurosurgeons, and trauma surgeons. This proposal builds on an existing research infrastructure that has supported acute neurological clinical trials both in the Emergency Department and in out-of-hospital setting using exemption from informed consent. OSUNETT has a well-established strong Hub-Spoke telestroke infrastructure with 14 spokes collaborating towards OSUNETT goals. The catchment area of OSUNETT extends over several counties with access to more than 3 million Ohio residents and more than 900,000 annual ED visits. OSUNETT is supported by 5 Level I Trauma Centers and 6 Primary Stroke Centers. OSUNETT has the experience, track record, and the support of a solid infrastructure to serve as strong participant in this important network.

描述（由申请人提供）：本提案是对2011年PAR-11-342神经系统紧急情况治疗试验（NETT）网络临床研究中心申请的回应。本摘要总结了俄亥俄州州立大学NETT网络（OSUNETT）的能力，以：1）开发一个坚实的，具有成本效益的基础设施，可以快速有效地实施儿科和成人急性神经系统临床试验; 2）快速识别，积极招募，有效招募，有效维护和保留 3）协调网络中多个分支的参与，确保所有参与试验者的安全和权利; 4）与网络成员合作开发和测试创新的远程医疗方法，以加强知情试验同意过程和患者随访; 5）使用NETT的倡议和计划作为培训初级教师和研究协调员的主要组成部分，以适当设计和进行急性神经学临床试验;以及 与其他NETT中心合作，促进研究成果在社区医院和急诊医生中的临床实践转移。OSUNETT是一个由急诊医生、神经重症监护医生、儿科医生、神经科医生、神经外科医生和创伤外科医生组成的多学科小组。该提案建立在现有研究基础设施的基础上，该基础设施支持急诊科和院外环境中使用知情同意豁免的急性神经系统临床试验。OSUNETT有一个完善的强大的中心辐条遥划基础设施，14个辐条合作实现OSUNETT的目标。OSUNETT的集水区延伸到几个县，可接触300多万俄亥俄州居民，每年有90多万艾德来访。OSUNETT由5个一级创伤中心和6个初级卒中中心提供支持。 OSUNETT拥有丰富的经验、良好的业绩记录和坚实的基础设施支持，可以成为这一重要网络的有力参与者。