The Ohio State University Regional Coordinating Stroke Center

俄亥俄州立大学区域中风协调中心

• 批准号: 8739336
• 负责人: Michel T Torbey
• 金额: $ 38.94万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8739336
• 关键词: Accident and Emergency department; Adult; Basic Science; Blood Vessels; Caring; Cerebrovascular Disorders; Childhood; Clinical; Clinical Research; Clinical Trials; Clinical Trials Network; Collaborations; Commit; Common Data Element; Community Hospitals; Consent; Contracts; Data; Development; Emergency Medicine; Emergency Situation; Enrollment; Ensure; Faculty; Foundations; Goals; Hospitals; Informed Consent; Institution; Institutional Review Boards; Intervention; Leadership; Medical center; Meta-Analysis; Modeling; Multi-Institutional Clinical Trial; National Institute of Neurological Disorders and Stroke; Nebraska; Neurology; Neuropsychology; Ohio; Participant; Patients; Pediatric Hospitals; Pediatric Neurology; Physicians; Population; Principal Investigator; Procedures; Process; Progress Review Group; Protocols documentation; Recovery; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Rights; Safety; Schedule; Scientist; Site; Solid; Specialist; Stroke; Stroke prevention; Telemedicine; Testing; Therapeutic; Time; Training; Training Activity; Translations; Universities; Visit; bench to bedside; cost effective; design; dissemination research; experience; follow-up; human subject protection; innovation; member; neuroimaging; next generation; pre-clinical; programs; public health relevance; stroke rehabilitation

DESCRIPTION (provided by applicant): The traditional model of conducting stroke clinical trials is characterized by redundancy and duplication of infrastructure and effort, inefficient and often incomplete recruitment, and difficulty in combining data across trials. The Comprehensive Stroke and Neurovascular Center at the Ohio State University (OSU) and Nationwide Children Hospital (NCH) are submitting this application for consideration to participate as a Regional Coordinating Stroke Center (RCC) to achieve the following specific aims; 1. Develop a solid, cost-effective infrastructure that can quickly and efficiently implements both pediatric and adult stroke clinical trials encompassing the full breadth of cerebrovascular disease; 2. Identify quickly, recruit aggressively, enroll efficiently and maintain and retain effectively the necessary study participants for each clinical study; 3. Coordinate the participation of multiple spokes in te network and ensure the safety and rights of all participants in the trials; and minimize participant burden through efficient scheduling and completion of all study procedures and clinical center visits; 4. Collaborate with network members in developing compelling clinical research applications and testing innovative telemedicine approaches to enhance informed trial consent process and patients follow-up; 5. Use the NINDS stroke network initiatives and programs as a major component in training junior faculty, and research coordinators in the appropriate design and conduct of stroke clinical trials. 6. Coordinate with other RCC hubs in the network to integrate data and use Stroke Common Data Element (CDE) to facilitate comparison of results across studies and facilitate meta-analysis research.

描述（由申请人提供）：进行中风临床试验的传统模式的特征是基础设施和工作的冗余和重复，效率低下， 通常招募不完全，难以合并试验数据。综合中风和神经血管中心在俄亥俄州州立大学（OSU）和全国儿童医院（NCH）正在提交本申请，以考虑参与作为一个区域协调中风中心（RCC），以实现以下具体目标：1。开发一个坚实、经济高效的基础设施，可以快速、高效地实施儿科和成人 中风临床试验涵盖脑血管疾病的全部广度; 2.快速识别、积极招募、高效注册，并有效维护和保留必要的 每项临床研究的研究参与者; 3.协调网络中多个分支机构的参与，确保所有参与者在试验中的安全和权利;通过有效安排和完成所有研究程序和临床中心访视，最大限度地减少参与者的负担; 4.与网络成员合作，开发引人注目的临床研究应用程序，并测试创新的远程医疗方法，以加强知情试验同意过程和患者随访; 5.使用NINDS卒中网络倡议和计划作为培训初级教师和研究协调员的主要组成部分，以适当设计和开展卒中临床试验。6.与网络中的其他RCC中心协调，以整合数据，并使用卒中通用数据元素（CDE）促进研究结果的比较，并促进荟萃分析研究。