The Ohio State University Regional Coordinating Stroke Center

俄亥俄州立大学区域中风协调中心

• 批准号: 9340348
• 负责人: Michel T Torbey
• 金额: $ 6.7万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9340348
• 关键词: Adult; Basic Science; Blood Vessels; Caring; Cerebrovascular Disorders; Childhood; Clinical; Clinical Research; Clinical Trials; Clinical Trials Network; Collaborations; Common Data Element; Community Hospitals; Consent; Contracts; Data; Development; Emergency Medicine; Emergency Situation; Emergency department visit; Enrollment; Ensure; Foundations; Goals; Health; Hospitals; Informed Consent; Institution; Institutional Review Boards; Intervention; Leadership; Medical center; Meta-Analysis; Modeling; Multi-Institutional Clinical Trial; National Institute of Neurological Disorders and Stroke; Nebraska; Neurology; Neuropsychology; Ohio; Participant; Patients; Pediatric Hospitals; Pediatric Neurology; Physicians; Population; Pre-hospital setting; Principal Investigator; Procedures; Process; Progress Review Group; Protocols documentation; Recovery; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Rights; Safety; Schedule; Scientist; Site; Solid; Specialist; Stroke; Stroke prevention; Telemedicine; Testing; Therapeutic; Time; Training; Training Activity; Translations; Universities; Visit; bench to bedside; cost effective; design; dissemination research; experience; faculty research; follow-up; human subject protection; innovation; member; neuroimaging; neurovascular; next generation; pre-clinical; programs; stroke rehabilitation

DESCRIPTION (provided by applicant): The traditional model of conducting stroke clinical trials is characterized by redundancy and duplication of infrastructure and effort, inefficient and often incomplete recruitment, and difficulty in combining data across trials. The Comprehensive Stroke and Neurovascular Center at the Ohio State University (OSU) and Nationwide Children Hospital (NCH) are submitting this application for consideration to participate as a Regional Coordinating Stroke Center (RCC) to achieve the following specific aims; 1. Develop a solid, cost-effective infrastructure that can quickly and efficiently implements both pediatric and adult stroke clinical trials encompassing the full breadth of cerebrovascular disease; 2. Identify quickly, recruit aggressively, enroll efficiently and maintain and retain effectively the necessary study participants for each clinical study; 3. Coordinate the participation of multiple spokes in te network and ensure the safety and rights of all participants in the trials; and minimize participant burden through efficient scheduling and completion of all study procedures and clinical center visits; 4. Collaborate with network members in developing compelling clinical research applications and testing innovative telemedicine approaches to enhance informed trial consent process and patients follow-up; 5. Use the NINDS stroke network initiatives and programs as a major component in training junior faculty, and research coordinators in the appropriate design and conduct of stroke clinical trials. 6. Coordinate with other RCC hubs in the network to integrate data and use Stroke Common Data Element (CDE) to facilitate comparison of results across studies and facilitate meta-analysis research.

描述（申请人提供）：进行中风临床试验的传统模式的特点是基础设施和工作量冗余和重复、效率低下和 通常招募不完整，并且难以合并试验中的数据。俄亥俄州立大学 (OSU) 和全国儿童医院 (NCH) 综合中风和神经血管中心正在提交此申请，以考虑作为区域中风协调中心 (RCC) 参与，以实现以下具体目标； 1. 开发一个坚实的、具有成本效益的基础设施，可以快速有效地实施儿科和成人 涵盖脑血管疾病全部范围的中风临床试验； 2. 快速识别、积极招募、高效招生、有效维持和留住必要的人才 每项临床研究的研究参与者； 3、协调te网络多个辐条的参与，确保所有试验参与者的安全和权利；通过有效安排和完成所有研究程序和临床中心访问，最大限度地减少参与者的负担； 4. 与网络成员合作开发引人注目的临床研究应用程序并测试创新的远程医疗方法，以加强知情试验同意流程和患者随访； 5. 将 NINDS 卒中网络倡议和计划作为培训初级教师和研究协调员适当设计和进行卒中临床试验的主要组成部分。 6. 与网络中的其他 RCC 中心协调整合数据并使用卒中通用数据元素 (CDE) 来促进研究结果的比较并促进荟萃分析研究。