Multidimensional pathways to healthy aging among Filipino women

描述（由申请人提供）：这项跨学科研究旨在确定生物，社会，经济和环境对妇女从中年到成年后期的过渡期健康和功能结果轨迹的影响。它旨在确定成年早期的经历和暴露，影响（1）身体健康，包括身体成分;血压，炎症和免疫反应的生物标志物接种疫苗，葡萄糖代谢失调和血脂异常;（2）身体功能和残疾;（3）认知;和（4）幸福的心理社会方面，包括关系质量和抑郁症。数据来自正在进行的以社区为基础的宿务纵向健康和营养调查（CLHNS）。自1983年以来，CLHNS通过多轮调查跟踪妇女。加上拟议的另外两轮调查，数据将涵盖30年的成年人生活，样本规模约为1 875人。参与者生活在菲律宾的宿务大都会，处于一个以快速城市化，社会变革和经济发展为特征的不断变化的环境中，为研究这些变化如何随着时间的推移影响健康和功能能力提供了理想的环境。目前，54%的妇女年龄在50-60岁之间，18%的妇女年龄在60岁以上。初步分析将确定发病和残疾风险的发展顺序和共同发生的模式。随后的多层次纵向分析将模拟物质环境随时间变化的影响，包括城市化及其卫生、空气质量、拥挤、住房密度等组成部分;以财富、收入和教育为代表的社会经济地位;家庭结构和关系，重点是祖父母的角色;与其身体和时间要求有关的工作的多个层面以及与地位和自主权有关的工作角色;以及饮食质量和身体活动。之所以选择这些风险，是因为它们具有实质性的重要性、强大的政策意义，以及CLHNS提供的特别详细、高质量的纵向数据。这项研究的重要优势是在发生与衰老有关的疾病和残疾之前收集了基线数据，并将能够确定因果关系。

DESCRIPTION (provided by applicant): This interdisciplinary study aims to identify biological, social, economic, and environmental influences on trajectories of health and functional outcomes in women in the transitional years from middle to later adulthood. It seeks to identify early adulthood experiences and exposures that affect (1) physical health, including body composition; blood pressure, biomarkers of inflammation and immune response to vaccination, dysregulation of glucose metabolism, and dyslipidemia; (2) physical functioning and disability; (3) cognition; and (4) psychosocial aspects of well-being including quality of relationships and depression. Data come from the ongoing, community-based Cebu Longitudinal Health and Nutrition Survey (CLHNS). The CLHNS has followed women through multiple survey rounds since 1983. With the proposed two additional survey rounds, the data will span a 30-year period of adult life, with a sample size of about 1875. Participants live in Metro Cebu, Philippines, in a changing environment characterized by rapid urbanization, social change, and economic development, providing an ideal setting in which to study how such changes influence health and functional capacity over time. At present 54% of women are 50-60 and 18% are >60 years old. Initial analysis will identify the sequence of development and patterns of co-occurrence of morbidity and disability risk. Subsequent multilevel longitudinal analysis will model the time-varying effects of the physical environment, including urbanization and its components of sanitation, air quality, crowding, housing density; socioeconomic status represented by wealth, income and education; family structure and relations with a focus on grandparenting roles; multiple dimensions of work related to its physical and time demands as well as work roles related to status and autonomy; as well as diet quality and physical activity. These exposures were selected because of their substantive importance, strong policy significance, and availability of especially detailed, high quality longitudinal data from the CLHNS. The study has the important advantage of having baseline data collected prior to the development of aging-related disease and disability, and will be able to identify causal associations.