Global Cardiometabolic Disease Training

摘要 我们建议更新我们的全球心脏代谢性疾病(GCMD)博士前培训计划。这个十字架- 以学科营养为重点的计划提供专门的培训，以培养一支 可以在基础科学、翻译科学和人口科学之间架起桥梁，以减少日益增长的负担和差距 GCMD.在低收入和中等收入国家，迫切需要减轻这一负担 受影响不成比例的地区，以及最需要更多专业技能和全球领导力的地区。这个 培训计划在吉林斯全球公共卫生学院的营养系管理 在北卡罗来纳大学医学院，这是一个合乎逻辑的、地理位置优越的地方，可以获得GCMD培训补助金。营养 科学将“组学”(如基因组学、蛋白质组学、代谢组学)、行为学和人口学结合在一起。 了解人口复杂病理生物学过程和潜在原因的方法和数据 GCMD的健康差异，从而为培训翻译的全球研究人员提供了一个强大的平台 这块地。我们的项目由两名资深教师共同指导，他们有很好的指导记录和广泛的 在GCMD研究方面的全球经验和领先地位。该计划由内部培训指导 委员会和一个外部顾问委员会。我们的22名北卡罗来纳大学培训教师都是科学家，拥有大量的 研究支持，广泛学科的优秀出版记录，以及强大的指导 经验。我们要求每年支持5名博士前实习生。学员完成营养学博士学位 和GCMD方案的具体要求，包括全球卫生和医疗保健专业课程 心血管疾病和深入培训的选择(1)对GCMD重要的专门方法，(2) 转化医学，或(3)实施科学。所有受训人员都参加了由该计划领导的研讨会 主任，指导研究实践，负责任的研究行为培训，以及指导 职业发展，包括提交NIH式的博士前和/或F奖或类似证书 申请外部资金，并与15名杰出的全球导师一起提供独特的全球实习机会 在11个国家的13所顶尖大学或研究中心工作的CMD研究人员。我们的培训计划 脱颖而出的原因是：(1)注重营养，这是全球疾病负担的主要原因；(2)生命 解决GCMD的课程方法；(3)跨学科关注原因，从细胞和 从分子到整个有机体，并对潜在的社会、经济、政治和环境进行核算 决定因素；(4)强调基本知识和营养发现的整合和转化 生物化学、生理学、遗传学和流行病学，到行为和环境方法以及 政策；以及(5)在GCMD研究中作为卓越榜样的杰出教师导师 和领导人与各国合作实施和评估大规模的监管努力，以防止 心脏代谢疾病。该项目正在培训GCMD研究领域的未来领导者。

Abstract We propose to renew our global cardiometabolic disease (GCMD) predoctoral training program. This cross- disciplinary nutrition-focused program provides specialized training to develop a cadre of researchers who can bridge basic, translational, and population science to reduce the growing burden and disparities in GCMD. There is critical need to reduce this burden in low- and middle-income countries that are disproportionately affected and where more specialized skills and global leadership are most needed. The training program is administered in the Department of Nutrition in the Gillings School of Global Public Health and in the UNC School of Medicine, a logical and well-placed home for a GCMD training grant. Nutrition science integrates “omics” (e.g., genomics, proteomics, metabolomics), behavioral, and population approaches and data to understand complex pathobiological processes and underlying causes of population health differences in GCMD, thus providing a strong platform for training translational global researchers in this field. Our program is co-directed by two senior faculty with strong mentoring records and extensive global experience and leadership in GCMD research. The program is guided by an internal training committee and an external advisory board. Our 22 UNC training faculty are scientists with substantial research support, excellent publication records across a wide range of disciplines, and strong mentoring experience. We request support for 5 predoctoral trainees per year. Trainees complete the PhD in nutrition and GCMD program-specific requirements, including specialized courses in global health and cardiovascular disease and options for in-depth training in (1) specialized methods important for GCMD, (2) translational medicine, or (3) implementation science. All trainees participate in a seminar led by the program directors, mentored research practicums, training in the responsible conduct of research, and mentoring for professional development, including submitting an NIH-style predoctoral and/or F award or similar application for extramural funding, and unique global internships with 15 global mentors who are exceptional CMD researchers working at 13 top universities or research centers in 11 countries. Our training program stands out because of its: (1) focus on nutrition, a major etiologic factor in the global disease burden; (2) life course approach to addressing GCMD; (3) interdisciplinary focus on causes ranging from cellular and molecular to whole organism and accounting for underlying social, economic, political, and environmental determinants; (4) emphasis on integration and translation of basic knowledge and discoveries from nutrition biochemistry, physiology, genetics, and epidemiology, to behavioral and environmental approaches and policies; and (5) outstanding faculty mentors who serve as role models for excellence in GCMD research and leaders working with countries to implement and evaluate large-scale regulatory efforts to prevent cardiometabolic disease. The program is training future leaders in GCMD research.