Global Cardiometabolic Disease Training

全球心脏代谢疾病培训

• 批准号: 9323556
• 负责人: Linda S Adair
• 金额: $ 23.9万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9323556
• 关键词: Disease; Training

 DESCRIPTION (provided by applicant): We propose a global cardiometabolic disease (GCMD) pre-doctoral training program. This interdisciplinary nutrition-focused program will provide specialized training to develop a cadre of researchers who can bridge basic biological science research and population-based studies to reduce the growing burden and disparities in global cardiometabolic disease morbidity and mortality. While there is increasing recognition of the high prevalence, burden, and upward trends in cardiometabolic disease, particularly in low and middle income countries, little has been done to address this important problem. The training program will be administered within the Department of Nutrition, which is housed within the Gillings School of Global Public Health and the UNC School of Medicine, making it a logical and well-placed home for a GCMD training grant. Nutrition research integrates genetic, epigenetic, biochemical, behavioral, and epidemiological data to understand the complex interactions between diet, chronic disease and obesity, thus providing a strong platform for training translational global science researchers in this field. Our program will be co-directed by two senior faculty members with strong mentoring records and extensive global experience and leadership in cardiometabolic disease-related research. The program will be guided by an internal training committee and an external advisory board. Our training faculty includes 21 senior and junior scientists with substantial research support and publication records across a wide range of disciplines. We request support for five pre-doctoral trainees per year. Trainees will complete the PhD in one of the department's three divisions (biochemistry, epidemiology, or intervention and policy) and in addition, trainees will complete GCMD training grant-specific requirements that include specialized courses in global health and cardiometabolic disease, implementation science/translational medicine, a seminar led by the program directors, mentored research practicums, training in the responsible conduct of research, mentoring for professional development and a global internship in a setting that will provide the student with direct exposure to cardiometabolic disease research outside of the US. Our training program stands out because of its: (1) focus on nutrition, a major etiologic factor in the global disease burden; (2) life course approach to addressing non-communicable diseases; (3) interdisciplinary focus on causes ranging from cellular and molecular to whole organism and accounting for underlying social, economic, political, and environmental determinants; (4) emphasis on integration and translation of basic knowledge and discoveries from nutrition biochemistry, physiology, genetics, and epidemiology, to behavioral and environmental approaches and policies; and (5) outstanding faculty mentors who serve as role models for excellence in global cardiometabolic disease research and leaders working with countries to implement and evaluate large-scale regulatory efforts to prevent cardiometabolic disease. The GCMD training program will train future leaders for careers in global cardiometabolic disease research.

 描述（由申请人提供）：我们提出了一个全球心脏代谢疾病（GCMD）博士前培训计划。这一以营养为重点的跨学科项目将提供专业培训，培养一支能够将基础生物科学研究和基于人群的研究联系起来的研究人员队伍，以减少全球心脏代谢疾病发病率和死亡率日益增长的负担和差距。虽然人们越来越认识到心脏代谢疾病的高患病率、负担和上升趋势，特别是在低收入和中等收入国家，但几乎没有采取任何措施来解决这一重要问题。该培训计划将在营养系内进行管理，该系位于Gillings全球公共卫生学院和Gillings医学院内，使其成为GCMD培训补助金的合理和良好场所。营养研究整合了遗传，表观遗传，生物化学，行为和流行病学数据，以了解饮食，慢性疾病和肥胖之间的复杂相互作用，从而为培训该领域的全球科学研究人员提供了一个强大的平台。我们的节目将由 两名资深教员在心脏代谢疾病相关研究方面拥有丰富的指导记录和广泛的全球经验和领导力。该计划将由内部培训委员会和外部咨询委员会指导。我们的培训教师包括21名高级和初级科学家，他们在广泛的学科中拥有大量的研究支持和出版记录。我们要求每年为5名博士前培训生提供支持。学员将在该部门的三个部门之一完成博士学位（生物化学，流行病学，或干预和政策），此外，学员将完成GCMD培训补助金的具体要求，包括全球健康和心脏代谢疾病，实施科学/转化医学，由项目主任领导的研讨会，指导研究实习，负责任的研究行为培训，专业发展指导和全球实习，为学生提供直接接触美国以外的心脏代谢疾病研究的环境。我们的培训计划脱颖而出，因为它：（1）专注于营养，全球疾病负担的主要病因因素;（2）解决非传染性疾病的生命过程方法;（3）跨学科关注从细胞和分子到整个有机体的原因，并考虑潜在的社会，经济，政治和环境决定因素;（4）强调从营养生物化学、生理学、遗传学和流行病学到行为和环境方法和政策的基础知识和发现的整合和转化;以及（5）作为全球心脏代谢疾病研究卓越榜样的杰出教师导师和与各国合作的领导者，实施和评估预防心脏代谢疾病的大规模监管工作。GCMD培训计划将为全球心脏代谢疾病研究培养未来的领导者。