Environmental influences on Child Health Outcomes (ECHO) Coordinating Center

总体摘要 儿童健康是由多种环境力量决定的;然而，令人惊讶的是，人们对儿童的健康状况知之甚少。 这些力量的相互作用。此外，尽管有一个新的共识，许多基因环境 相互作用决定儿童健康，关于遗传和环境因素如何影响儿童健康， 联合收割机以促进或防止不良结果。环境对儿童健康的影响 （ECHO）协调中心（CC）提案旨在进一步加强广泛的儿童健康研究 社区通过促进合作来增加关于这些复杂影响的知识体系 在内部和外部利益相关者之间，并支持ECHO计划的研究，以加强 为了子孙后代的健康。杜克临床研究所（DCRI）具有独特的优势， 在过去七年成功担任ECHO CC后，担任ECHO CC。此外，本发明还提供了一种方法， DCRI管理着超过30个活跃的网络和行政协调中心，并已成为 儿科研究拟议的ECHO CC的独特之处包括：1）丰富的经验和跟踪 领导团队在支持初始ECHO计划和开展多项儿科 研究; 2）DCRI的儿科业务专业知识;以及3）现有的强大的行政基础设施 有成效和有效率地管理协调联合国雄心勃勃的努力的责任 ECHO计划。该小组由P.布赖恩史密斯和琳达埃德尔博士领导。史密斯博士是一位生物学家， 有成就的儿科研究员和网络领导者。他曾担任PI的ECHO CC，因为其 七年前的创始Adair博士因长期儿科队列的领导而享誉国际 问题研究在过去的六年里，Adair博士在ECHO计划中担任了多个领导角色 年，包括监督ECHO机会和基础设施基金（OIF），以及在协议中的作用 开发和实施、培训和出版物。欧共体人道主义协调委员会的具体目标是： 提供组织基础设施，以协调和监督ECHO计划的研究活动; 2）支持 ECHO队列委员会以及所有ECHO计划组成部分和利益相关者之间的沟通; 3） 管理ECHO OIF，并通过包容性研究促进对多样化研究人员的培训 环境ECHO CC将建立和监督所需的基础设施，以协调多个 ECHO计划的成员级别。这一基础设施将侧重于学习有价值的方法 通过汇集来自ECHO的大量数据，了解环境暴露情况 队列研究中心。ECHO CC将使科学工作更快，更有效，同时保护人类 科目这种基础设施之所以成为可能，是因为DCRI的专业知识，它不仅具有广泛的 在协调儿科研究方面有丰富的经验，但也具备必要的平台。

OVERALL ABSTRACT Child health is determined by multiple environmental forces; however, surprisingly little is known about the interactions of these forces. In addition, despite an emerging consensus that numerous gene-environment interactions determine child health, much remains unknown about how genetic and environmental factors combine to promote or prevent adverse outcomes. This Environmental influences on Child Health Outcomes (ECHO) Coordinating Center (CC) proposal seeks to further strengthen the broad children's health research community to increase the body of knowledge about these complicated effects by fostering collaboration among internal and external stakeholders and supporting the research of the ECHO Program to enhance the health of children for generations to come. The Duke Clinical Research Institute (DCRI) is uniquely positioned to serve as the ECHO CC after successfully serving as the ECHO CC for the last seven years. In addition, DCRI manages >30 active network and administrative coordinating centers and has emerged as a leader in pediatric research. Unique features of the proposed ECHO CC include: 1) extensive experience and track record of the leadership team in the support of the initial ECHO Program and conduct of multiple pediatric studies; 2) pediatric operational expertise of the DCRI; and 3) existing, robust administrative infrastructure necessary to effectively and efficiently manage responsibilities for coordinating the ambitious efforts of the ECHO Program. The team is led by Drs. P. Brian Smith and Linda Adair. Dr. Smith is a neonatologist and an accomplished pediatric researcher and leader of networks. He served as PI of the ECHO CC since its inception seven years ago. Dr. Adair is internationally renowned for leadership of long-term pediatric cohort studies. Dr. Adair has been instrumental in multiple leadership roles in the ECHO Program over the last six years including oversight of the ECHO Opportunities and Infrastructure Fund (OIF), and roles in protocol development and implementation, training, and publications. The specific aims for the ECHO CC are to: 1) provide organizational infrastructure to coordinate and oversee ECHO Program's research activities; 2) support ECHO Cohort Committees and communication among all ECHO Program Components and stakeholders; 3) manage the ECHO OIF and foster training of a diverse cohort of investigators through an inclusive research environment. The ECHO CC will establish and oversee the required infrastructure to coordinate the multiple levels of membership in the ECHO Program. This infrastructure will focus on methods of learning valuable information about environmental exposures through aggregation of massive amounts of data from ECHO Cohort Study Sites. The ECHO CC will make scientific efforts faster and more efficient while protecting human subjects. This infrastructure is possible because of the expertise of DCRI, which not only has extensive experience in coordinating pediatric studies but also has the essential platforms ready.