Behavioral interventions to reduce heavy drinking in HIV-infected men in primary care.

减少初级保健中艾滋病毒感染男性酗酒的行为干预措施。

基本信息

  • 批准号:
    8838920
  • 负责人:
  • 金额:
    $ 43.32万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-09-01 至 2020-05-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY Heavy drinking in HIV-infected patients can lead to low antiretroviral therapy adherence and poor virologic control, greater sexual risk taking, increased risk of liver disease, and decreased cognitive function. Therefore, reductions in drinking may have particularly positive and widespread effects in HIV-infected patients. Men who have sex with men (MSM) continue to represent the majority of new HIV infections, and HIV-infected MSM have rates of hazardous drinking as high as 33%. Therefore, developing and testing interventions to reduce heavy drinking in HIV-infected MSM is a very high public health priority. There have been relatively few alcohol interventions tested that focus on MSM, and only two have addressed drinking in HIV-infected MSM. Although recent studies indicate that behavioral interventions can reduce heavy drinking in HIV-infected patients, much remains unknown about the efficacy of different approaches to behavioral intervention and their unique and combined effects. The purpose of the present study is to conduct a fully-crossed 2 X 2 X 2 factorial randomized controlled trial with a diverse sample of 224 MSM recruited from 2 urban HIV primary care clinics (one in the Northeast and one in the South). The first study factor will compare brief advice (BA) vs. a motivation intervention (MI) that contains detailed personalized normative and HIV-specific feedback. The second factor compares an interactive text messaging (ITM) intervention vs. no text messaging. The final factor compares intervention of low intensity and duration (two sessions over 1 month) to extended intervention (EI) entailing 5 sessions over 9 months. BA and MI will be delivered by a core set of interventionists from a central location using a webcam-enabled telemedicine system, which can facilitate larger-scale implementation. The design will allow us to test the hypothesis that MI compared to BA, ITM compared to no ITM, and EI compared to no EI, will result in significantly greater reductions in number of alcoholic drinks consumed and number of heavy drinking days at 6- and 12-month follow-ups. Secondary outcomes include engagement in unprotected anal intercourse, ART adherence and viral suppression, CD4 cell count, liver function tests, and neurocognitive function. We also will test the hypothesis that the effects of MI, ITM, and EI on drinking will be moderated by alcohol use disorder status and readiness to change drinking such that these interventions will be relatively more efficacious in those with a current disorder and those with low readiness. The study will provide crucial evidence regarding which intervention approaches, alone or in combination, are likely to be most efficient to implement on a large scale in HIV care settings.
项目摘要 HIV感染者大量饮酒可能导致抗逆转录病毒治疗依从性低和病毒学不良 控制,更大的性风险,增加肝脏疾病的风险和认知功能下降。因此,我们认为, 减少饮酒可能对艾滋病毒感染者产生特别积极和广泛的影响。的男人 与男性发生性关系(MSM)继续占新感染艾滋病毒的大多数, 危险饮酒率高达33%因此,制定和测试干预措施,以减少 在感染艾滋病毒的男男性行为者中大量饮酒是一个非常高的公共卫生优先事项。酒精含量相对较少 目前,已经测试的干预措施主要针对男男性行为者,只有两项针对感染艾滋病毒的男男性行为者的饮酒问题。虽然 最近的研究表明,行为干预可以减少艾滋病毒感染者的大量饮酒, 仍然不知道不同的行为干预方法的有效性及其独特性, 综合效应。本研究的目的是进行一个完全交叉的2 × 2 × 2析因随机 一项对照试验,从2个城市艾滋病初级保健诊所招募了224名MSM(其中一个在 一个在东北,一个在南方)。第一个学习因素将比较简短的建议(BA)与动机 干预(MI),其中包含详细的个性化规范和艾滋病毒的具体反馈。第二个因素 比较了交互式短信(ITM)干预与无短信干预。最后一个因素比较 低强度和持续时间的干预(1个月内两次)到扩展干预(EI), 9个月以上的会议。BA和MI将由一组核心干预专家从中心位置提供 使用网络摄像头远程医疗系统,这有助于更大规模的实施。设计 将允许我们检验MI与BA相比、ITM与无ITM相比以及EI与无ITM相比的假设。 EI,将导致消费的酒精饮料数量和重 6个月和12个月随访时的饮酒天数。次要结局包括参与无保护肛门 性交、ART依从性和病毒抑制、CD4细胞计数、肝功能检查和神经认知 功能我们还将检验以下假设:MI、ITM和EI对饮酒的影响将受到以下因素的调节: 酒精使用障碍状态和改变饮酒的准备,这些干预措施将相对 对那些目前有障碍和准备不足的人更有效。这项研究将提供关键的 关于哪种干预方法(单独或组合)可能最有效, 在艾滋病毒护理环境中大规模实施。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Christopher W. Kahler其他文献

Gedragsrelatietherapie versus individuele therapie voor vrouwen met alcoholafhankelijkheid: een gerandomiseerde klinische trial
Gedragsrelatiethapie 与个体疗法 voor vrouwen metoolafhankelijkheid:een gerandomiseerde klinische 试验
  • DOI:
    10.1007/s12440-016-0024-2
  • 发表时间:
    2016
  • 期刊:
  • 影响因子:
    64.8
  • 作者:
    Jeremiah A. Schumm;Timothy J. O'Farrell;Christopher W. Kahler;M. Murphy;Patrice Muchowski
  • 通讯作者:
    Patrice Muchowski
The effects of switching to the standardized research electronic cigarette in people with HIV who smoke in the United States
在美国,对于吸烟的艾滋病毒感染者改用标准化研究电子烟的影响
  • DOI:
    10.1016/j.ypmed.2025.108309
  • 发表时间:
    2025-07-01
  • 期刊:
  • 影响因子:
    3.200
  • 作者:
    Patricia A. Cioe;William V. Lechner;Garrett S. Stang;Christopher W. Kahler;Karen T. Tashima;Thomas Eissenberg;Jennifer W. Tidey
  • 通讯作者:
    Jennifer W. Tidey
Intolerance for withdrawal discomfort and motivation predict voucher-based smoking treatment outcomes for smokers with substance use disorders
  • DOI:
    10.1016/j.addbeh.2014.12.003
  • 发表时间:
    2015-04-01
  • 期刊:
  • 影响因子:
  • 作者:
    Damaris J. Rohsenow;Jennifer W. Tidey;Christopher W. Kahler;Rosemarie A. Martin;Suzanne M. Colby;Alan D. Sirota
  • 通讯作者:
    Alan D. Sirota
Pain Severity and Experiences with Pain Management Predict Alcohol Use Among Men Who Have Sex with Men Living with HIV
  • DOI:
    10.1007/s10461-025-04652-8
  • 发表时间:
    2025-02-10
  • 期刊:
  • 影响因子:
    2.400
  • 作者:
    Erin Ferguson;David W. Pantalone;Peter M. Monti;Kenneth H. Mayer;Christopher W. Kahler
  • 通讯作者:
    Christopher W. Kahler
Effects of optimism and stage of change on alcohol use and problems among sexual minority men with HIV participating in a brief motivational interviewing intervention
  • DOI:
    10.1016/j.josat.2024.209599
  • 发表时间:
    2025-02-01
  • 期刊:
  • 影响因子:
  • 作者:
    Benjamin L. Berey;Nadine R. Mastroleo;David W. Pantalone;Kenneth H. Mayer;Peter M. Monti;Christopher W. Kahler
  • 通讯作者:
    Christopher W. Kahler

Christopher W. Kahler的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Christopher W. Kahler', 18)}}的其他基金

Development and pilot testing of a multimodal web-based program to address heavy drinking during smoking cessation
开发和试点测试多模式网络计划,以解决戒烟期间酗酒问题
  • 批准号:
    9226007
  • 财政年份:
    2016
  • 资助金额:
    $ 43.32万
  • 项目类别:
Development and pilot testing of a multimodal web-based program to address heavy drinking during smoking cessation
开发和试点测试多模式网络计划,以解决戒烟期间酗酒问题
  • 批准号:
    9017537
  • 财政年份:
    2016
  • 资助金额:
    $ 43.32万
  • 项目类别:
Positive Psychotherapy for Smoking Cessation Enhanced with Text Messaging: A Randomized Controlled Trial
通过短信增强戒烟积极心理治疗:随机对照试验
  • 批准号:
    9310231
  • 财政年份:
    2016
  • 资助金额:
    $ 43.32万
  • 项目类别:
Web-facilitated intervention for heavy drinking and HIV risk
针对酗酒和艾滋病毒风险的网络辅助干预
  • 批准号:
    8921751
  • 财政年份:
    2015
  • 资助金额:
    $ 43.32万
  • 项目类别:
Web-facilitated intervention for heavy drinking and HIV risk
针对酗酒和艾滋病毒风险的网络辅助干预
  • 批准号:
    9265364
  • 财政年份:
    2015
  • 资助金额:
    $ 43.32万
  • 项目类别:
Mechanisms of Behavior Change Resource Core for Alcohol-HIV Interventions
酒精-艾滋病毒干预措施的行为改变资源核心机制
  • 批准号:
    8548212
  • 财政年份:
    2012
  • 资助金额:
    $ 43.32万
  • 项目类别:
Mechanisms of Behavior Change Resource Core for Alcohol-HIV Interventions
酒精-艾滋病毒干预措施的行为改变资源核心机制
  • 批准号:
    8452403
  • 财政年份:
    2012
  • 资助金额:
    $ 43.32万
  • 项目类别:
Mechanisms of Behavior Change Resource Core for Alcohol-HIV Interventions
酒精-艾滋病毒干预措施的行为改变资源核心机制
  • 批准号:
    8719887
  • 财政年份:
    2012
  • 资助金额:
    $ 43.32万
  • 项目类别:
Development of Positive Psychotherapy for Smoking Cessation
戒烟积极心理疗法的发展
  • 批准号:
    8207864
  • 财政年份:
    2011
  • 资助金额:
    $ 43.32万
  • 项目类别:
Development of Positive Psychotherapy for Smoking Cessation
戒烟积极心理疗法的发展
  • 批准号:
    8039348
  • 财政年份:
    2011
  • 资助金额:
    $ 43.32万
  • 项目类别:

相似海外基金

The investigation of chronic alcohol consumption enhanced aging colon in elder mice and the mechanism of suppressed on aging colon tissues by sesame lignans continuous intake
长期饮酒促进老年小鼠结肠衰老的研究及持续摄入芝麻木脂素抑制结肠组织衰老的机制
  • 批准号:
    23K10904
  • 财政年份:
    2023
  • 资助金额:
    $ 43.32万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Molecular mechanisms of carcinogenesis and symptoms associated with alcohol consumption
致癌的分子机制和饮酒相关症状
  • 批准号:
    23K05734
  • 财政年份:
    2023
  • 资助金额:
    $ 43.32万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Internal Sources of Minority Stress and Alcohol Consumption
少数群体压力和饮酒的内部根源
  • 批准号:
    10742318
  • 财政年份:
    2023
  • 资助金额:
    $ 43.32万
  • 项目类别:
Characterizing the Relationship Between Alcohol Consumption and Neuron-Derived Exosomal MicroRNA Cargo in an Adolescent-Young Adult Twin Cohort
青少年双胞胎队列中酒精消耗与神经元衍生的外泌体 MicroRNA 货物之间关系的表征
  • 批准号:
    10452928
  • 财政年份:
    2022
  • 资助金额:
    $ 43.32万
  • 项目类别:
Endocrine regulation of alcohol consumption and fear learning
饮酒和恐惧学习的内分泌调节
  • 批准号:
    10483780
  • 财政年份:
    2022
  • 资助金额:
    $ 43.32万
  • 项目类别:
The impact of friends sharing different modalities of alcohol-related social media content on alcohol consumption: A longitudinal examination of changes in content shared by social networks over time
朋友分享不同形式的酒精相关社交媒体内容对饮酒的影响:对社交网络分享内容随时间变化的纵向研究
  • 批准号:
    10534428
  • 财政年份:
    2022
  • 资助金额:
    $ 43.32万
  • 项目类别:
Cannabis' Impact on Alcohol Consumption: Integrating Laboratory and Ecological Momentary Assessment Methods
大麻对酒精消费的影响:整合实验室和生态瞬时评估方法
  • 批准号:
    10339931
  • 财政年份:
    2022
  • 资助金额:
    $ 43.32万
  • 项目类别:
Chronic alcohol consumption results in elevated Autotaxin levels that suppress anti-tumor immunity
长期饮酒会导致自分泌运动因子水平升高,从而抑制抗肿瘤免疫力
  • 批准号:
    10370159
  • 财政年份:
    2022
  • 资助金额:
    $ 43.32万
  • 项目类别:
Cannabis' Impact on Alcohol Consumption: Integrating Laboratory and Ecological Momentary Assessment Methods
大麻对酒精消费的影响:整合实验室和生态瞬时评估方法
  • 批准号:
    10595096
  • 财政年份:
    2022
  • 资助金额:
    $ 43.32万
  • 项目类别:
Technology-based assessments and intervention to reduce alcohol consumption and improve HIV viral suppression in the Florida Cohort
基于技术的评估和干预,以减少佛罗里达队列的饮酒量并改善艾滋病病毒抑制
  • 批准号:
    10707386
  • 财政年份:
    2022
  • 资助金额:
    $ 43.32万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了