KLF1 regulatory networks in health and disease

KLF1 健康和疾病调控网络

• 批准号: nhmrc : 1030143
• 负责人: Dr Timothy Bailey
• 金额: $ 40.69万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/klf1-regulatory-networks-health-disease/110735
• 关键词: KLF1; regulatory; networks; health; disease

We will investigate how the master control gene, Kruppel-like factor 1, orchestrates production of red blood cells. We will use genetic and cell biology approaches to determine exactly how this factor interprets the genome blueprint in a cell specific manner. We will also determine how mutations in KLF1 cause human diseases such as congenital dyserythropoietic anemia and hereditary persistence of fetal haemoglobin. This has implications for reactivation of HbF in adults with sickle cell disease.

我们将研究主控基因克虏伯样因子1如何协调红细胞的产生。我们将使用遗传和细胞生物学方法来确定该因子如何以细胞特定的方式解释基因组蓝图。我们还将确定KLF1突变如何导致人类疾病，如先天性促红细胞增生性贫血和胎儿血红蛋白的遗传性持久性。这对成人镰状细胞病HbF的再激活具有启示意义。