Training Program in Pediatric Cancer Epidemiology and Control

儿童癌症流行病学和控制培训计划

• 批准号: 8878197
• 负责人: MELISSA L. BONDY
• 金额: $ 34.64万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-22 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8878197
• 关键词: Address; Area; Cancer Biology; Cancer Center; Cancer Control; Cancer Control Research; Childhood; Childhood Cancer Treatment; Clinical; Clinical Treatment; Complement; Doctor of Medicine; Doctor of Philosophy; Educational Curriculum; Environment; Epidemiologist; Epidemiology; Faculty; Fellowship; Fellowship Program; Foundations; Funding; Future; Genomics; Goals; Grant; Institution; Institutional National Research Service Award; Leadership; Malignant Childhood Neoplasm; Medical center; Medicine; Melissa; Mentors; Minority; Molecular Epidemiology; Pediatric Hospitals; Pediatric Oncology; Peer Review; Pharmacology; Physicians; Positioning Attribute; Postdoctoral Fellow; Prevention; Program Evaluation; Publications; Qualifying; Recruitment Activity; Research; Research Personnel; Research Project Grants; Scientist; Staging; Texas; Training; Training Programs; University of Texas M D Anderson Cancer Center; Writing; base; cancer epidemiology; cancer prevention; career; career development; college; experience; genetic epidemiology; graduate student; interest; member; multidisciplinary; next generation; obesity in children; oncology; pre-doctoral; programs; statistics; survivorship; treatment trial

DESCRIPTION (provided by applicant): Multidisciplinary training programs to prepare the next generation of pediatric cancer epidemiology and control researchers are urgently needed. We propose to establish a cross-institutional training program to address this underdeveloped area and provide future physician scientists the training opportunities required to develop their careers in pediatric oncology and childhood cancer epidemiologists. This training program will be under the umbrella of the Childhood Cancer Epidemiology and Prevention Center (CCEPC), a unique collaborative effort between Baylor College of Medicine/Texas Children's Hospital and The University of Texas MD Anderson Cancer Center (MDACC). The unique faculty strengths of these two neighbor institutions include pediatric oncology, molecular epidemiology, genomics, survivorship research, childhood obesity, statistics, and pharmacology, in the outstanding environment of the Texas Medical Center in Houston, provide the ideal setting for this training program. Our overall goal is to establish a multidisciplinary curriculum-driven training and career development program in Pediatric Cancer Epidemiology and Control (PCEC). We propose the following specific aims: 1. Recruit well qualified post-doctoral fellows (Ph.D.), and pediatric oncology clinical fellows (M.D. or M.D./Ph.D.) to receive specific mentored training (didactic and research experiences) in childhood cancer epidemiology and cancer prevention in a multi-disciplinary setting. We will also have a specific focus on recruiting quality minority applicants. 2. Develop a multidisciplinary curriculum that will provide a strong foundation in epidemiology, genetics, cancer biology, survivorship research, and cancer control. 3. Provide rich mentored research experiences for post-doctoral and clinical fellows. 4. Incorporate program evaluation and long-term tracking of trainees to assess efficacy of this training and career development program. 5. Provide career development mini-courses, seminars, and experiential activities for post-doctoral and clinical fellows to facilitate their transition from fellow to early-stage faculty member.

描述(由申请人提供)：迫切需要多学科培训计划，为下一代儿科癌症流行病学和控制研究人员做准备。我们建议建立一个跨机构的培训计划来解决这个不发达的领域，并为未来的内科科学家提供在儿科肿瘤学和儿童癌症流行病学家领域发展所需的培训机会。该培训计划将在儿童癌症流行病学和预防中心(CCEPC)的框架下进行，该中心是贝勒医学院/德克萨斯儿童医院和德克萨斯大学MD安德森癌症中心(MDACC)的独特合作努力。这两个相邻机构独特的师资优势包括儿科肿瘤学、分子流行病学、基因组学、生存研究、儿童肥胖症、统计学和药理学，在休斯敦得克萨斯医学中心的卓越环境中，为本培训计划提供了理想的环境。我们的总体目标是在儿科癌症流行病学和控制(PCEC)领域建立一个多学科课程驱动的培训和职业发展计划。我们提出了以下具体目标：1.招募高素质的博士后研究员(Ph.D.)和儿科肿瘤临床研究员(M.D.或M.D./Ph.D.)在多学科环境中接受儿童癌症流行病学和癌症预防方面的具体指导培训(教学和研究经验)。我们还将特别注重招聘高素质的少数族裔申请者。2.开发多学科课程，为流行病学、遗传学、癌症生物学、生存研究和癌症控制奠定坚实的基础。3.为博士后和临床研究员提供丰富的导师研究经验。4.将项目评估和对学员的长期跟踪结合起来，评估本培训和职业发展计划的效果。5.为博士后和临床研究员提供职业发展小型课程、研讨会和体验活动，帮助他们从研究员过渡到早期教师。

项目成果

Family-based exome-wide assessment of maternal genetic effects on susceptibility to childhood B-cell acute lymphoblastic leukemia in hispanics.

• DOI: 10.1002/cncr.30241
• 发表时间: 2016-12-01
• 期刊: CANCER
• 影响因子: 6.2
• 作者: Archer, Natalie P.;Perez-Andreu, Virginia;Scheurer, Michael E.;Rabin, Karen R.;Peckham-Gregory, Erin C.;Plon, Sharon E.;Zabriskie, Ryan C.;De Alarcon, Pedro A.;Fernandez, Karen S.;Najera, Cesar R.;Yang, Jun J.;Antillon-Klussmann, Federico;Lupo, Philip J.
• 通讯作者: Lupo, Philip J.

Evaluation of racial disparities in pediatric optic pathway glioma incidence: Results from the Surveillance, Epidemiology, and End Results Program, 2000-2014.

• DOI: 10.1016/j.canep.2018.04.005
• 发表时间: 2018-06
• 期刊: Cancer epidemiology
• 影响因子: 2.6
• 作者: Peckham-Gregory EC;Montenegro RE;Stevenson DA;Viskochil DH;Scheurer ME;Lupo PJ;Schiffman JD
• 通讯作者: Schiffman JD

Residential Radon Exposure and Incidence of Childhood Lymphoma in Texas, 1995-2011.

• DOI: 10.3390/ijerph121012110
• 发表时间: 2015-09-25
• 期刊: International journal of environmental research and public health
• 作者: Peckham EC;Scheurer ME;Danysh HE;Lubega J;Langlois PH;Lupo PJ
• 通讯作者: Lupo PJ

Maternal folate genes and aberrant DNA hypermethylation in pediatric acute lymphoblastic leukemia.

• DOI: 10.1371/journal.pone.0197408
• 发表时间: 2018
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Schraw JM;Yiu TT;Lupo PJ;Tsavachidis S;Rau R;Bondy ML;Rabin KR;Shen L;Scheurer ME
• 通讯作者: Scheurer ME

Pediatric cancer epigenome and the influence of folate.

小儿癌症表观基因组和叶酸的影响。

• DOI: 10.2217/epi.15.42
• 发表时间: 2015
• 期刊: Epigenomics
• 影响因子: 3.8
• 作者: Yiu,TeresaT;Li,Wei
• 通讯作者: Li,Wei