2/2 Partnership to Study Racial/Ethnic Differences in GI Cancer Biology

2/2 合作研究胃肠道癌症生物学的种族/民族差异

• 批准号: 9038098
• 负责人: William Richard McCombie
• 金额: $ 15.55万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-25 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9038098
• 关键词: 3-Dimensional; Address; African; African American; Applications Grants; Area; Awareness; Basic Science; Bioinformatics; Biological; Biological Markers; Biology; Biomedical Research; Cancer Biology; Cancer Center at Cold Spring Harbor Laboratory; Cancer Patient; Cancer Research Project; Caucasians; Clinical; Clinical Data; Clinical Research; Code; Collection; Colon Carcinoma; Colorectal Cancer; Communication; Communities; Community Health Education; Community Outreach; Companions; Computational Science; Consensus; Controlled Vocabulary; Core Biopsy; Critiques; DNA; Data; Data Element; Data Set; Decision Making; Detection; Development Plans; Disease; Drug Targeting; Ductal; Education; Emerging Technologies; Evolution; Exhibits; Faculty; Genetic; Genomics; Goals; Grant; Healthcare; Heterogeneity; Histologic; Histology; Human; Image; In Vitro; Incidence; Individual; Institution; Knowledge; Laboratories; Link; Malignant Neoplasms; Malignant neoplasm of pancreas; Maps; Medical; Medical center; Mentors; Mentorship; Metadata; Methods; Minority Groups; Molecular; Molecular Analysis; Molecular and Cellular Biology; NCI Scholars Program; NCI-Designated Cancer Center; Organoids; Outcome; Pancreas; Patients; Population; Procedures; Proteins; RNA methylation; Research; Research Personnel; Research Project Grants; Resources; Sampling; Science; Specimen; Stem cells; Students; Technology; Testing; Tissues; Training; Training and Education; Translational Research; Tumor-Derived; Ultrasonography; Underrepresented Minority; Underrepresented Students; Universities; Unresectable; Vocabulary; anticancer research; base; biobank; biomedical informatics; cancer care; cancer health disparity; care delivery; career development; chemotherapy; demographics; design; doctoral student; epigenetic profiling; epigenomics; ethnic minority population; experience; graduate medical education; graduate student; health disparity; high risk; improved; innovation; interest; medically underserved; mortality; novel; outreach program; programs; public health relevance; racial and ethnic; racial/ethnic difference; screening; success; symposium; translational medicine; translational study; tumor

 DESCRIPTION (provided by applicant): ABSTRACT Two SUNY medical campuses (SUNY Stony Brook and SUNY Downstate) serving underrepresented minority communities with cancer health disparities are partnering with the NCI designated Cancer Center at the Cold Spring Harbor Laboratories to evaluate biological and genetic differences in GI cancers (colorectal and pancreatic) that may link to differences in cancer incidence and outcome observed in racial and ethnic minorities (URM). For the Cancer Research Program, we aim to augment the representation of underrepresented minorities in the collection of bio specimens and linked high dimensional 'omic datasets generated from these bio specimens. In this planning grant we plan to develop a SUNY Downstate GI BioBank that operates in parallel to the SUNY Stony Brook GI BioBank using standard operating procedures. We are planning the development of an integrative biomedical informatics platform that will link the bio specimens with longitudinal clinical data and with the data generated from these specimens. An initial step in the planning procedure is to develop a consensus of what data elements to include and for developing a controlled vocabulary. To increase community participatory research among racial and ethnic minority populations, we plan to leverage the resources and expertise of the SUNY Downstate Brooklyn Health Disparities Center(led by Dr. Moro Salifu) in developing community education and outreach programs in underserved communities with a high proportion of racial and ethnic minorities. The collection of bio specimens will be driven by two pilot research projects, P1 and P2. In P1, we propose to compare genomic and epigenetic profiling of URM colon cancers with non URM colon cancers. In P2, we propose to test the feasibility of adapting an innovative 3-D method to grow pancreatic organoids (miniature pancreas) from progenitor cells (developed in Dr. Tuveson's laboratory at CSHL) from fine needle core biopsies of human pancreatic cancers collected at the two SUNY medical campuses. We plan to compare genomic and epigenomic profiling of URM pancreatic organoids with those of non-URM organoids. For the Training and Education Program, we are committed to improving the participation of underrepresented minorities in biomedical research and in increasing awareness of health disparities among established cancer researchers. In this planning grant the two SUNY medical campuses will partner with CSHL to create an integrated doctoral certificate program Scholars in BioMedical Sciences in Cancer Health Disparities. This program is designed to engage doctoral students in translational medicine, particularly in cancer health disparities, by promoting in these students an understanding of the presentation, progression and treatment of diseases related to their area of thesis research. The track requires the addition of a clinical co-mentor to the usual student-basic science advisor team who will help guide the student's biomedical/clinical research and immerse the student in clinical experiences, vocabulary, and the overall culture of clinical research.