Pilot 1: Genomic and epigenomic profiling of colon cancers in racial and ethnic minority patients

摘要-试点研究项目1（P1） 两个SUNY医学院（SUNY斯托尼布鲁克和SUNY Downstate）为代表性不足的少数族裔提供服务 有癌症健康差异的社区正在与NCI指定的癌症中心合作， 春港实验室（CSHL）评估结直肠癌的生物学和遗传学差异， 可能与在少数种族和族裔中观察到的癌症发病率和结果的差异有关。我们计划 开发一个SUNY Downstate GI生物银行，这将大大增加代表性不足的代表性 在生物标本的收集方面，少数国家将使用目前在 在纽约州立大学斯托尼布鲁克GI生物银行。此外，SUNY收集的临床元数据元素 Downstate将是相同的，并利用纽约州立大学斯托尼布鲁克使用的共同控制词汇 GI生物银行。为了增加少数种族和少数民族人口的社区参与性研究，我们 计划利用纽约州立大学下州布鲁克林健康差异中心的资源和专业知识 由摩罗萨利夫博士）在发展社区教育和服务不足的社区推广计划 少数种族和族裔的比例很高（>70%的非洲裔美国人）。在P1中，我们建议生成 使用NCI支持的CSHL共享DNA资源的结肠癌基因组和表观遗传学分析数据 由Dick McCombie博士指导的核心（CSHL联系P1的PI）生成测序数据将提供 立即反馈给Downstate GI BioBank，以监测其收集工作的Q/A。 该基因组和表观基因组数据将被并行微阵列和RNA-Seq上生成的数据所取代。 Dr. Daddie威廉姆斯（SUNY联系P1的PI）的相同编码去识别样本。我们预计 使链接的数据集可在综合生物医学信息学平台正在开发的， 拟议的P20项目将促进与更大的癌症共享这些非常有价值的数据集。 研究社区。

ABSTRACT – PILOT RESEARCH PROJECT 1 (P1) Two SUNY medical campuses (SUNY Stony Brook and SUNY Downstate) serving underrepresented minority communities with cancer health disparities are partnering with the NCI designated Cancer Center at the Cold Spring Harbor Laboratories (CSHL) to evaluate biological and genetic differences in colorectal cancers that may link to differences in cancer incidence and outcome observed in racial and ethnic minorities. We plan to develop a SUNY Downstate GI BioBank that will greatly augment the representation of underrepresented minorities in the collection of biospecimens that will use the same standard operating procedures currently in place at the SUNY Stony Brook GI BioBank. Furthermore the clinical metadata elements collected at SUNY Downstate will be the same and utilize a common controlled vocabulary that is used by the SUNY Stony Brook GI BioBank. To increase community participatory research among racial and ethnic minority populations, we plan to leverage the resources and expertise of the SUNY Downstate Brooklyn Health Disparities Center (led by Dr. Moro Salifu) in developing community education and outreach programs in underserved communities with a high proportion of racial and ethnic minorities (>70% African Americans). In P1, we propose to generate genomic and epigenetic profiling data of colon cancers using the NCI supported CSHL Shared DNA Resource Core directed by Dr. Dick McCombie (CSHL contact PI for P1) Generating the sequencing data will provide immediate feedback to the Downstate GI BioBank with respect to monitoring Q/A for their collection efforts. This genomic and epigenomic data will be linkable to parallel microarray and RNA-Seq data generated on the same coded deidentified samples by Dr. Jennie Williams (SUNY contact PI for P1). We anticipate that making the linked datasets available on the integrated biomedical informatics platform being developed by this proposed P20 project will facilitate sharing of these extremely valuable datasets with the larger cancer research community.