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Pilot 1: Genomic and epigenomic profiling of colon cancers in racial and ethnic minority patients

Pilot 1: Genomic and epigenomic profiling of colon cancers in racial and ethnic minority patients
试点 1:少数民族患者结肠癌的基因组和表观基因组分析
批准号:
9038100
负责人:
William Richard McCombie
金额:
$4.44万
依托单位国家:
美国
项目类别:
财政年份:
2015
资助国家:
美国
项目状态:
已结题
起止时间:
2015-09-25 至 2019-08-31
关键词:
AddressAfricanAfrican AmericanArchivesBase SequenceBiologicalBlood specimenBudgetsCancer BiologyCancer Center at Cold Spring Harbor LaboratoryCaucasiansClinicalCodeCollaborationsCollectionColonColon CarcinomaColorectalColorectal CancerCommunitiesCommunity Health EducationCommunity OutreachControlled VocabularyCounty HospitalsDNADNA LibraryDataData SetDatabasesDiagnosisElementsEmerging TechnologiesEpigenetic ProcessEquipment and SuppliesEthnic groupExcisionExhibitsFeedbackFormalinGastrointestinal NeoplasmsGenerationsGeneticGenomic DNAGenomicsGrantHigh-Throughput Nucleotide SequencingHumanIncidenceIndividualInstitutionLaboratoriesLeadLeadershipLinkMalignant NeoplasmsMapsMedicalMessenger RNAMetadataMethodsMicroRNAsMinority GroupsModelingMolecularMonitorNCI-Designated Cancer CenterOutcomePancreasParaffin EmbeddingPatientsPeripheral Blood Mononuclear CellPilot ProjectsPopulationPreventionProceduresProcessProteinsRNARNA libraryRaceResearchResearch InfrastructureResearch PersonnelResearch Project GrantsResolutionResourcesSamplingSequence AnalysisSocioeconomic FactorsSpecimenStagingStudentsTextThe Cancer Genome AtlasTissuesTrainingTraining and EducationTranslational ResearchUnderrepresented MinorityUnited StatesWorkabstractinganticancer researchbasebiobankbiomedical informaticscancer health disparitycolon cancer patientsdemographicsdifferential expressionepigenetic profilingepigenomicsethnic minority populationexomehealth disparityhigh riskimprovedinsightinterestmethylation patternmortalityoutreach programprospectiveracial and ethnicracial/ethnic differencesample collectiontranscriptome sequencingtumortumor DNA

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中文摘要
翻译
摘要-试点研究项目1 (p1)
英文摘要
ABSTRACT – PILOT RESEARCH PROJECT 1 (P1) Two SUNY medical campuses (SUNY Stony Brook and SUNY Downstate) serving underrepresented minority communities with cancer health disparities are partnering with the NCI designated Cancer Center at the Cold Spring Harbor Laboratories (CSHL) to evaluate biological and genetic differences in colorectal cancers that may link to differences in cancer incidence and outcome observed in racial and ethnic minorities. We plan to develop a SUNY Downstate GI BioBank that will greatly augment the representation of underrepresented minorities in the collection of biospecimens that will use the same standard operating procedures currently in place at the SUNY Stony Brook GI BioBank. Furthermore the clinical metadata elements collected at SUNY Downstate will be the same and utilize a common controlled vocabulary that is used by the SUNY Stony Brook GI BioBank. To increase community participatory research among racial and ethnic minority populations, we plan to leverage the resources and expertise of the SUNY Downstate Brooklyn Health Disparities Center (led by Dr. Moro Salifu) in developing community education and outreach programs in underserved communities with a high proportion of racial and ethnic minorities (>70% African Americans). In P1, we propose to generate genomic and epigenetic profiling data of colon cancers using the NCI supported CSHL Shared DNA Resource Core directed by Dr. Dick McCombie (CSHL contact PI for P1) Generating the sequencing data will provide immediate feedback to the Downstate GI BioBank with respect to monitoring Q/A for their collection efforts. This genomic and epigenomic data will be linkable to parallel microarray and RNA-Seq data generated on the same coded deidentified samples by Dr. Jennie Williams (SUNY contact PI for P1). We anticipate that making the linked datasets available on the integrated biomedical informatics platform being developed by this proposed P20 project will facilitate sharing of these extremely valuable datasets with the larger cancer research community.
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Training and Education Program
  • 批准号:
    9038102
  • 项目类别:
  • 资助金额:
    $3.24万
  • 财政年份:
    2015
  • 负责人:
    William Richard McCombie
  • 依托单位:
Next Generation DNA Sequencer
  • 批准号:
    8826440
  • 项目类别:
  • 资助金额:
    $52.31万
  • 财政年份:
    2015
  • 负责人:
    William Richard McCombie
  • 依托单位:
2/2 Partnership to Study Racial/Ethnic Differences in GI Cancer Biology
  • 批准号:
    9150533
  • 项目类别:
  • 资助金额:
    $15.52万
  • 财政年份:
    2015
  • 负责人:
    William Richard McCombie
  • 依托单位:
2/2 Partnership to Study Racial/Ethnic Differences in GI Cancer Biology
  • 批准号:
    9038098
  • 项目类别:
  • 资助金额:
    $15.55万
  • 财政年份:
    2015
  • 负责人:
    William Richard McCombie
  • 依托单位:
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