Pilot 1: Genomic and epigenomic profiling of colon cancers in racial and ethnic minority patients

摘要--试点研究项目1(P1) 两所纽约州立大学医学院(纽约州立大学石溪分校和纽约州立大学下州分校)为少数族裔提供服务 有癌症健康差距的社区正在与NCI指定的寒冷癌症中心合作 春港实验室(CSHL)评估结直肠癌的生物学和遗传差异 可能与在种族和少数民族中观察到的癌症发病率和结果的差异有关。我们计划 开发一个纽约州立大学北部的GI生物库，将大大增加代表不足的人的代表性 生物检疫剂收集中的少数族裔将使用目前在#年的相同标准操作程序 在纽约州立大学石溪GI生物库。此外，在纽约州立大学收集的临床元数据元素 DownState将是相同的，并使用SUNY Stony Brook使用的通用受控词汇表 GI生物库。为增加少数族裔人士的社区参与性研究，我们 计划利用纽约州立大学布鲁克林健康差距中心(LEAD)的资源和专业知识 Moro Salifu博士)在服务不足的社区发展社区教育和外展方案 有很高比例的种族和少数民族(&gt；70%非裔美国人)。在P1中，我们建议生成 利用NCI支持的CSHL共享DNA资源获得结肠癌基因组和表观遗传学数据 由Dick McCombie博士(CSHL联系P1的PI)指导的核心将提供测序数据 立即反馈给DownState GI Biobank，以监控他们收集工作的Q/A。 这些基因组和表观基因组数据将与并行微阵列和在 由Jennie Williams博士(纽约州立大学P1联系PI)提供相同的编码已确认样本。我们预料到 使链接的数据集在由该公司开发的综合生物医学信息学平台上可用 拟议的P20项目将促进与较大的癌症共享这些极其有价值的数据集 研究社区。

ABSTRACT – PILOT RESEARCH PROJECT 1 (P1) Two SUNY medical campuses (SUNY Stony Brook and SUNY Downstate) serving underrepresented minority communities with cancer health disparities are partnering with the NCI designated Cancer Center at the Cold Spring Harbor Laboratories (CSHL) to evaluate biological and genetic differences in colorectal cancers that may link to differences in cancer incidence and outcome observed in racial and ethnic minorities. We plan to develop a SUNY Downstate GI BioBank that will greatly augment the representation of underrepresented minorities in the collection of biospecimens that will use the same standard operating procedures currently in place at the SUNY Stony Brook GI BioBank. Furthermore the clinical metadata elements collected at SUNY Downstate will be the same and utilize a common controlled vocabulary that is used by the SUNY Stony Brook GI BioBank. To increase community participatory research among racial and ethnic minority populations, we plan to leverage the resources and expertise of the SUNY Downstate Brooklyn Health Disparities Center (led by Dr. Moro Salifu) in developing community education and outreach programs in underserved communities with a high proportion of racial and ethnic minorities (>70% African Americans). In P1, we propose to generate genomic and epigenetic profiling data of colon cancers using the NCI supported CSHL Shared DNA Resource Core directed by Dr. Dick McCombie (CSHL contact PI for P1) Generating the sequencing data will provide immediate feedback to the Downstate GI BioBank with respect to monitoring Q/A for their collection efforts. This genomic and epigenomic data will be linkable to parallel microarray and RNA-Seq data generated on the same coded deidentified samples by Dr. Jennie Williams (SUNY contact PI for P1). We anticipate that making the linked datasets available on the integrated biomedical informatics platform being developed by this proposed P20 project will facilitate sharing of these extremely valuable datasets with the larger cancer research community.