Large-scale genome-wide analyses to investigate the genetic aetiology of miscarriage

大规模全基因组分析以研究流产的遗传病因学

• 批准号: nhmrc : GNT1163040
• 金额: $ 19.53万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/large-scale-genome-aetiology-miscarriage/1379270
• 关键词: Large; scale; genome; wide; analyses

In Australia around 25% of clinically-confirmed pregnancies end in miscarriage. While up to 60% are likely due to chromosomal or structural anomalies in the developing embryo, the causes of the remainder are typically unknown. Using large-scale genome-wide analyses, we will investigate the extent to which genetic factors, in the form of genetic variants, influence miscarriage risk. If funded, this project will significantly advance our understanding of the genetic aetiology of miscarriage.

在澳大利亚，大约25%的经临床确认的怀孕以流产告终。虽然高达60%的原因可能是由于发育中的胚胎中的染色体或结构异常，但其余的原因通常尚不清楚。利用大规模的全基因组分析，我们将调查以遗传变异形式存在的遗传因素对流产风险的影响程度。如果得到资助，这个项目将极大地促进我们对流产遗传病因的理解。