Optical elastography for assessment of myocardial regeneration

这个R01应用程序将研究一种新的信号通路，海马通路， 哺乳动物心脏再生长期目标是开发新的治疗方法， 通过在成人心脏中产生新的心肌细胞来治疗心力衰竭患者。的 本申请的目的是深入了解心脏的生物力学特性， 由河马信号调节的组织。核心假设是希波 信号传导是一种负调控途径， 成年哺乳动物心脏通过促进心脏的更像胎儿的弹性轮廓 肌肉.具体的目的是确定河马调节的生物力学特性 和心脏老化，以确定生物力学特性的动态变化后， 心肌梗死，并确定再生的功能特征， 海马突变心脏的心肌细胞。 该项目在概念和技术上都具有创新性。有待检验的概念 是心肌细胞生物学的新想法和新的尖端成像技术 是用来解决假设的。重要性很高，因为没有 治疗由于心肌细胞损失引起的心力衰竭。设计方法， 心肌细胞是非常重要的。

This R01 application will investigate a novel signaling pathway, the Hippo pathway, in mammalian heart regeneration. The long-term goal is to develop new treatments for patients with heart failure by generating new cardiomyocytes in the adult heart. The objectives of this application are to gain insight into biomechanical properties of cardiac tissue that are regulated by Hippo signaling. The central hypothesis is that Hippo signaling is a negative regulatory pathway that prevents cardiomyocyte regeneration in the adult mammalian heart by promoting a more fetal-like elasticity profile of cardiac muscle. The specific aims are to define the Hippo regulated biomechanical properties and cardiac aging, to determine dynamic changes in biomechanical properties after myocardial infarction, and to determine the functional characteristics of regenerated cardiomyocytes in Hippo mutant hearts. The project is both conceptually and technically innovative. The concepts to be tested are new ideas in cardiomyocyte biology and new and cutting edge imaging technologies are used to address hypotheses. The significance is high because there are no treatments for heart failure due to cardiomyocyte loss. Devising ways to generate new cardiomyocytes is highly significant.