Center for Research in Diagnostics and Discovery

诊断与发现研究中心

• 批准号: 9010912
• 负责人: W. Ian Lipkin
• 金额: $ 722.82万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-03-07 至 2019-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9010912
• 关键词: Biological Assay; Biomedical Engineering; Communities; Country; Detection; Diagnostic; Disease susceptibility; Effectiveness; Epidemic; Genetic; Geographic Locations; Infectious Agent; Instruction; Integration Host Factors; Knowledge; Medical; Methodology; Molecular Biology; Pharmaceutical Preparations; Public Health; Research; Research Personnel; System; Systems Biology; Technology; Testing; Vaccines; accurate diagnosis; cost; diagnostic assay; improved; member; novel; pathogen; rapid diagnosis; tool

Accurate diagnosis is essential for proper medical treatment. Often this is confounded by the lack of or limitation of informative diagnostic assays and tools. Infectious agents rarely found in a given community or country commonly are not screened for as multiple single diagnostic assays are cost-prohibitive and tests for the most likely agent is deemed warranted. Yet it is increasingly clear that as infectious agents appear in , new geographic regions and contexts, the medical and public heath communities must improve and modernize the methodologies they utilize. The Center for Research in Diagnostics and Discovery aims to develop, validate and implement multiplex platforms and predictive strategies that will advance detection of novel pathogens, identify host factors that influence susceptibility of disease and predict effectiveness of drugs and vaccines. We will bring together researchers in the fields of molecular biology, systems biology, genetics, and bioengineering. We will also bring together members of the public health communities and conservation biologists. Together, the investigators in the Center for Research in Diagnostics and Discovery will advance knowledge and platforms for the detection of agents that are either previously unidentified, known causes of epidemics, or select agents by developing and utilizing systems that could be rapidly redirected for pathogens of any type.

准确的诊断对于适当的医疗是至关重要的。这通常会被缺少或 信息量大的诊断分析和工具的局限性。传染病病原体很少在给定的社区或 通常不会对国家/地区进行筛查，因为多项单一诊断检测的成本过高，而且检测 最有可能的代理人被认为是有理由的。然而，越来越清楚的是，随着传染病病原体的出现， 在新的地理区域和背景下，医疗和公共卫生社区必须改善和 使他们使用的方法现代化。诊断和发现研究中心的目标是 开发、验证和实施多路传输平台和预测性策略，以推动检测 新的病原体，识别影响疾病易感性的宿主因素，并预测 药物和疫苗。我们将汇聚分子生物学、系统生物学、 遗传学和生物工程。我们还将召集公共卫生界的成员，并 保护生物学家。诊断和发现研究中心的研究人员共同努力 将推进用于检测以前未被识别的代理的知识和平台， 已知的流行病原因，或通过开发和利用可以迅速 已重定向为任何类型的病原体。