Center for Research in Diagnostics and Discovery

诊断与发现研究中心

• 批准号: 9440950
• 负责人: W. Ian Lipkin
• 金额: $ 617.18万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-03-07 至 2020-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9440950
• 关键词: Biological Assay; Biomedical Engineering; Communities; Community Health; Country; Detection; Diagnostic; Disease susceptibility; Effectiveness; Epidemic; Genetic; Geographic Locations; Infectious Agent; Instruction; Integration Host Factors; Knowledge; Medical; Methodology; Modernization; Molecular Biology; Pharmaceutical Preparations; Public Health; Research; Research Personnel; System; Systems Biology; Technology; Testing; Vaccines; accurate diagnosis; cost; diagnostic assay; improved; member; novel; pathogen; rapid diagnosis; tool

Accurate diagnosis is essential for proper medical treatment. Often this is confounded by the lack of or limitation of informative diagnostic assays and tools. Infectious agents rarely found in a given community or country commonly are not screened for as multiple single diagnostic assays are cost-prohibitive and tests for the most likely agent is deemed warranted. Yet it is increasingly clear that as infectious agents appear in , new geographic regions and contexts, the medical and public heath communities must improve and modernize the methodologies they utilize. The Center for Research in Diagnostics and Discovery aims to develop, validate and implement multiplex platforms and predictive strategies that will advance detection of novel pathogens, identify host factors that influence susceptibility of disease and predict effectiveness of drugs and vaccines. We will bring together researchers in the fields of molecular biology, systems biology, genetics, and bioengineering. We will also bring together members of the public health communities and conservation biologists. Together, the investigators in the Center for Research in Diagnostics and Discovery will advance knowledge and platforms for the detection of agents that are either previously unidentified, known causes of epidemics, or select agents by developing and utilizing systems that could be rapidly redirected for pathogens of any type.

准确的诊断对适当的治疗至关重要。这往往是混淆的缺乏或 信息性诊断测定和工具的局限性。在特定社区很少发现的传染性病原体或 由于多个单一诊断测定成本过高， 最有可能的代理人被认为是授权的。然而，越来越清楚的是，随着传染源的出现， 新的地理区域和环境，医疗和公共卫生界必须改善， 使他们使用的方法现代化。诊断和发现研究中心旨在 开发、验证和实施多重平台和预测战略， 新的病原体，确定影响疾病易感性的宿主因素，并预测 药物和疫苗。我们将汇集分子生物学，系统生物学， 遗传学和生物工程。我们还将汇集公共卫生界的成员， 保育生物学家诊断和发现研究中心的研究人员 将推进知识和平台，用于检测以前未识别的代理， 流行病的已知原因，或通过开发和利用可以快速 重定向任何类型的病原体。

项目成果

Adenovirus and herpesvirus diversity in free-ranging great apes in the Sangha region of the Republic Of Congo.

• DOI: 10.1371/journal.pone.0118543
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Seimon TA;Olson SH;Lee KJ;Rosen G;Ondzie A;Cameron K;Reed P;Anthony SJ;Joly DO;Karesh WB;McAloose D;Lipkin WI
• 通讯作者: Lipkin WI

Transcriptional Profiling Confirms the Therapeutic Effects of Mast Cell Stabilization in a Dengue Disease Model.

转录分析证实了登革热疾病模型中肥大细胞稳定的治疗作用。

• DOI: 10.1128/jvi.00617-17
• 发表时间: 2017-09-15
• 期刊: Journal of virology
• 影响因子: 5.4
• 作者: Morrison J;Rathore APS;Mantri CK;Aman SAB;Nishida A;St John AL
• 通讯作者: St John AL

Human Norovirus Epitope D Plasticity Allows Escape from Antibody Immunity without Loss of Capacity for Binding Cellular Ligands.

• DOI: 10.1128/jvi.01813-18
• 发表时间: 2019-01-15
• 期刊: Journal of virology
• 影响因子: 5.4
• 作者: Lindesmith LC;Brewer-Jensen PD;Mallory ML;Yount B;Collins MH;Debbink K;Graham RL;Baric RS
• 通讯作者: Baric RS

A Systems Approach Reveals MAVS Signaling in Myeloid Cells as Critical for Resistance to Ebola Virus in Murine Models of Infection.

• DOI: 10.1016/j.celrep.2016.12.069
• 发表时间: 2017-01-17
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Dutta M;Robertson SJ;Okumura A;Scott DP;Chang J;Weiss JM;Sturdevant GL;Feldmann F;Haddock E;Chiramel AI;Ponia SS;Dougherty JD;Katze MG;Rasmussen AL;Best SM
• 通讯作者: Best SM

Characterization of a Pathogenic Full-Length cDNA Clone and Transmission Model for Porcine Epidemic Diarrhea Virus Strain PC22A.

• DOI: 10.1128/mbio.01451-15
• 发表时间: 2016-01-05
• 期刊: mBio
• 影响因子: 6.4
• 作者: Beall A;Yount B;Lin CM;Hou Y;Wang Q;Saif L;Baric R
• 通讯作者: Baric R