Center for Research in Diagnostics and Discovery

诊断与发现研究中心

• 批准号: 9440950
• 负责人: W. Ian Lipkin
• 金额: $ 617.18万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-03-07 至 2020-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9440950
• 关键词: Biological Assay; Biomedical Engineering; Communities; Community Health; Country; Detection; Diagnostic; Disease susceptibility; Effectiveness; Epidemic; Genetic; Geographic Locations; Infectious Agent; Instruction; Integration Host Factors; Knowledge; Medical; Methodology; Modernization; Molecular Biology; Pharmaceutical Preparations; Public Health; Research; Research Personnel; System; Systems Biology; Technology; Testing; Vaccines; accurate diagnosis; cost; diagnostic assay; improved; member; novel; pathogen; rapid diagnosis; tool

Accurate diagnosis is essential for proper medical treatment. Often this is confounded by the lack of or limitation of informative diagnostic assays and tools. Infectious agents rarely found in a given community or country commonly are not screened for as multiple single diagnostic assays are cost-prohibitive and tests for the most likely agent is deemed warranted. Yet it is increasingly clear that as infectious agents appear in , new geographic regions and contexts, the medical and public heath communities must improve and modernize the methodologies they utilize. The Center for Research in Diagnostics and Discovery aims to develop, validate and implement multiplex platforms and predictive strategies that will advance detection of novel pathogens, identify host factors that influence susceptibility of disease and predict effectiveness of drugs and vaccines. We will bring together researchers in the fields of molecular biology, systems biology, genetics, and bioengineering. We will also bring together members of the public health communities and conservation biologists. Together, the investigators in the Center for Research in Diagnostics and Discovery will advance knowledge and platforms for the detection of agents that are either previously unidentified, known causes of epidemics, or select agents by developing and utilizing systems that could be rapidly redirected for pathogens of any type.

准确的诊断对于适当的治疗至关重要。通常，这是由于缺乏或 限制信息性诊断测定和工具。在给定社区或 由于多个单一诊断测定的成本效果，国家通常不会被筛选 最有可能的代理人被认为有必要。然而，越来越明显的是，随着传染剂出现， 新的地理区域和环境，医疗和公共卫生社区必须改善， 现代化他们使用的方法。诊断和发现研究中心的目的是 开发，验证和实施多路复用平台和预测策略，以提高检测 新的病原体，识别影响疾病敏感性并预测有效性的宿主因素 毒品和疫苗。我们将在分子生物学，系统生物学，系统生物学领域汇集研究人员 遗传学和生物工程。我们还将汇集公共卫生社区的成员 保护生物学家。一起，诊断与发现研究中心的研究人员 将促进知识和平台以检测以前未知的代理商， 流行病的已知原因，或通过开发和利用可以迅速发展的系统选择代理的原因 为任何类型的病原体重定向。

项目成果

Transcriptional Profiling Confirms the Therapeutic Effects of Mast Cell Stabilization in a Dengue Disease Model.

• DOI: 10.1128/jvi.00617-17
• 发表时间: 2017-09-15
• 期刊: Journal of virology
• 影响因子: 5.4
• 作者: Morrison J;Rathore APS;Mantri CK;Aman SAB;Nishida A;St John AL
• 通讯作者: St John AL

Adenovirus and herpesvirus diversity in free-ranging great apes in the Sangha region of the Republic Of Congo.

• DOI: 10.1371/journal.pone.0118543
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Seimon TA;Olson SH;Lee KJ;Rosen G;Ondzie A;Cameron K;Reed P;Anthony SJ;Joly DO;Karesh WB;McAloose D;Lipkin WI
• 通讯作者: Lipkin WI

Human Norovirus Epitope D Plasticity Allows Escape from Antibody Immunity without Loss of Capacity for Binding Cellular Ligands.

• DOI: 10.1128/jvi.01813-18
• 发表时间: 2019-01-15
• 期刊: Journal of virology
• 影响因子: 5.4
• 作者: Lindesmith LC;Brewer-Jensen PD;Mallory ML;Yount B;Collins MH;Debbink K;Graham RL;Baric RS
• 通讯作者: Baric RS

Investigation of the Plasma Virome from Cases of Unexplained Febrile Illness in Tanzania from 2013 to 2014: a Comparative Analysis between Unbiased and VirCapSeq-VERT High-Throughput Sequencing Approaches.

• DOI: 10.1128/msphere.00311-18
• 发表时间: 2018-08-22
• 期刊: mSphere
• 影响因子: 4.8
• 作者: Williams SH;Cordey S;Bhuva N;Laubscher F;Hartley MA;Boillat-Blanco N;Mbarack Z;Samaka J;Mlaganile T;Jain K;d'Acremont V;Kaiser L;Lipkin WI
• 通讯作者: Lipkin WI

Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome.

• DOI: 10.1186/s40168-017-0261-y
• 发表时间: 2017-04-26
• 期刊: Microbiome
• 影响因子: 15.5
• 作者: Nagy-Szakal D;Williams BL;Mishra N;Che X;Lee B;Bateman L;Klimas NG;Komaroff AL;Levine S;Montoya JG;Peterson DL;Ramanan D;Jain K;Eddy ML;Hornig M;Lipkin WI
• 通讯作者: Lipkin WI