Virology, Immunology, and Microbiology Core

病毒学、免疫学和微生物学核心

• 批准号: 8919057
• 负责人: JULIE AE NELSON
• 金额: $ 31.69万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8919057
• 关键词: AIDS clinical trial group; AIDS prevention; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Analytical Chemistry; Award; Biological Assay; Biometry; Biostatistics Core; Central America; China; Clinical; Clinical Pharmacology; Clinical Trials; Collaborations; Communities; Core Facility; Criminal Justice; Databases; Development; Diagnosis; Distance Learning; Epidemic; Epidemiology; Evaluation; Faculty; Family health status; Funding; Future; Goals; HIV; HIV-1; Health; Historically Black Colleges and Universities; IMPAACT; Immune; Immunogenetics; Immunologics; Immunology; Institutes; Institution; International; Leadership; Link; Malawi; Mentors; Mentorship; Microbiology; Monitor; North Carolina; Nucleic Acid Amplification Tests; Pathogenesis; Patients; Phenotype; Play; Prevention; Research; Research Activity; Research Infrastructure; Research Personnel; Research Support; Resources; Role; Scientist; Services; Sexually Transmitted Diseases; Site; South Africa; Strategic Planning; Surveys; System; Testing; Training; United States National Institutes of Health; Work; Zambia; base; behavioral/social science; co-infection; cohort; member; outreach program; programs; tool; virology; working group

The goals of the Virology, Immunology & Microbiology (VIM) Core are to enhance the research capacity of the UNC CFAR research community by providing access to state­ of-the-art tools research, and for diagnosis and monitoring HIV-1-positive patients in clinical trials. The VIM Core also provides leadership to promote HIVIAIDS research through collaboration, training, and mentoring. The specific aims are to 1) provide quality virologic, immunologic and microbiologic assays and services, 2) provide training and mentorship to the domestic and international CFAR community and build capacity at international sites, 3) provide leadership through activities locally, nationally, and internationally, 4) support NIH networks and CFAR-CFAR collaborations by participating in WIHS, HPTN, IMPAACT, and ACTG, 5) support new CFAR initiatives through collaborations with UNC CFAR members, and 6) engage in evaluation and strategic planning, using input from user surveys, an Internal Advisory Board, and the CFAR External Advisory Board. Through these activities, the Virology, Immunology & Microbiology Core will provide key infrastructure support for the HIVIAIDS and HIV­ coinfection research activity of the CFAR membership. These activities will have a significant impact on the future of the epidemic by providing assays for HIV-1 and other sexually transmitted infections (including ultra-low copy number and POC HIV-1 assays and nucleic acid amplification testing for non-HIV STis), biospecimen procurement and distribution, immune phenotype, function and immunogenetic testing, training and mentoring new US and international scientists, and providing leadership locally, nationally, and globally.

病毒学、免疫学和微生物学(VIM)核心的目标是提高北卡罗来纳大学CFAR研究界的研究能力，方法是提供最先进的工具研究，并在临床试验中诊断和监测HIV-1阳性患者。VIM核心还为促进艾滋病毒研究提供领导 通过协作、培训和指导。其具体目标是：1)提供高质量的病毒学、免疫学和微生物学分析和服务；2)向国内和国际CFAR社区提供培训和指导，并在国际地点建设能力；3)通过地方、国家和国际活动发挥领导作用；4)通过参加WIHS、HPTN、IMPAACT和ACTG，支持NIH网络和CFAR-CFAR合作；5)通过与UNC CFAR成员合作，支持新的CFAR倡议；以及6)利用用户调查、内部咨询委员会和CFAR外部咨询委员会的意见，参与评价和战略规划。通过这些活动，病毒学、免疫学和微生物学核心将为CFAR成员的艾滋病和艾滋病毒合并感染研究活动提供关键的基础设施支持。这些活动将通过提供艾滋病毒-1和其他性传播感染的检测(包括超低拷贝数和POC艾滋病毒-1检测)，对疫情的未来产生重大影响 该中心的主要业务包括为非HIV性传播感染患者提供疫苗和核酸扩增测试)、生物疫苗采购和分销、免疫表型、功能和免疫遗传测试、培训和指导美国和国际的新科学家，并在地方、国家和全球范围内发挥领导作用。