UNC Center for AIDS Research Core J VIM

北卡罗来纳大学艾滋病研究中心核心 J VIM

• 批准号: 9117226
• 负责人: JULIE AE NELSON
• 金额: $ 32.26万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9117226
• 关键词: AIDS clinical trial group; AIDS prevention; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Anatomy; Antibodies; Area; Basic Science; Biological Assay; Biological Markers; CD4 Lymphocyte Count; CLIA certified; Cells; Chlamydia trachomatis; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Communicable Diseases; Communities; Comorbidity; Consultations; DNA; Detection; Development; Diagnosis; Diagnostic; Education and Outreach; Enrollment; Ensure; Equipment; Evaluation; Flow Cytometry; Fostering; Funding; Genotype; Goals; Grant; HIV; HIV Seropositivity; HIV diagnosis; HIV resistance; Human immunodeficiency virus test; IMPAACT; Immunologics; Immunology; Immunology procedure; Individual; Industry; International; Laboratories; Lead; Leadership; Measurement; Mentors; Mentorship; Microbiology; Monitor; Mycoplasma genitalium; Neisseria gonorrhoeae; North Carolina; Outcome; Paris, France; Participant; Patient Monitoring; Patients; Pharmacology; Prevention; Process; Protocols documentation; Publications; RNA; Recommendation; Research; Research Personnel; Research Priority; Resources; Scientist; Services; Sexually Transmitted Diseases; Site; Source; Specimen; Specimen Handling; Strategic Planning; Surveys; Technology; Testing; Text; Tissues; Training; Training and Education; Trichomonas vaginalis; United States National Institutes of Health; Universities; Viral; Viral Load result; Woman; Women' s Health; Work; Writing; abstracting; assay development; base; co-infection; cohort; cost effective; cytokine; design; enzyme linked immunospot assay; human leukocyte antigen testing; improved; laboratory experience; meetings; new technology; next generation sequencing; novel; quality assurance; repository; research study; response; sex risk; tool; virology

PROJECT SUMMARY/ABSTRACT –VIROLOGY, IMMUNOLOGY & MICROBIOLOGY (VIM) CORE The broad, long-term objectives of the Virology, Immunology & Microbiology (VIM) Core are to provide laboratory support for HIV/AIDS-related basic and clinical HIV research to the UNC CFAR community. The specific aims include: (1) provide access to a diverse array of cost-effective services, (2) develop and evaluate new technologies applicable to research by CFAR investigators, (3) support of CFAR initiatives and collaborative research, (4) promote synergy between UNC CFAR Cores, UNC CFAR SWGs, and other CFARs, (5) provide mentoring, training, education, and outreach in the areas of virology, immunology, and microbiology, and (6) engage in evaluation and strategic planning. To achieve these aims, the VIM Core collaborates with UNC CFAR investigators to provide the services, specimens, equipment, or training needed by the investigators to achieve their research goals. The Core contributes to grant writing, design of experiments, and write-up of results. The services offered include specimen processing for clinical trials, provision of specimens from HIV-positive and HIV-negative individuals, viral quantitation, flow cytometry, measurement of antibodies and cytokines, and diagnostics for HIV and other sexually transmitted infections. New assays are developed in response to investigator requests and priority research areas for the CFAR. Management and strategic planning of the Core will be guided by consultation with the Core Directors, surveys of the CFAR membership, an Internal Advisory Board, an External Advisory Board, and through discussions at CFAR retreats.

项目概要/摘要 – 病毒学、免疫学和微生物学 (VIM) 核心 病毒学、免疫学和微生物学 (VIM) 核心的广泛、长期目标是提供 为北卡罗来纳大学 CFAR 社区提供与艾滋病毒/艾滋病相关的基础和临床艾滋病毒研究的实验室支持。这 具体目标包括：(1) 提供各种具有成本效益的服务，(2) 开发和评估 适用于 CFAR 研究人员研究的新技术，(3) 支持 CFAR 举措以及 合作研究，(4) 促进北卡罗来纳大学 CFAR 核心、北卡罗来纳大学 CFAR SWG 和其他 CFAR，(5) 在病毒学、免疫学和免疫学领域提供指导、培训、教育和推广 微生物学，(6) 参与评估和战略规划。为了实现这些目标，VIM 核心 与 UNC CFAR 调查人员合作，提供所需的服务、样本、设备或培训 由研究者来实现他们的研究目标。核心有助于拨款写作、设计 实验，并写出结果。提供的服务包括临床试验的样本处理， 提供 HIV 阳性和 HIV 阴性个体的样本、病毒定量、流式细胞术、 抗体和细胞因子的测量以及艾滋病毒和其他性传播感染的诊断。 新的检测方法是根据研究者的要求和 CFAR 的优先研究领域而开发的。 核心的管理和战略规划将以与核心董事的协商、调查为指导 CFAR 成员、内部顾问委员会、外部顾问委员会以及通过讨论 CFAR 撤退。