Determining the dynamic influence of social networks on development and health trajectories

 描述(申请人提供)：治疗和预防疾病并改善人类健康的能力不仅需要详细了解导致疾病过程的生物系统的复杂相互作用，而且还需要了解社会复杂性对生物系统影响的潜在机制。发展系统科学方法提供了独特的方法，通过调查社会制度在调节发育过程中生物系统之间相互作用的作用，来阐明社会制度影响健康的机制。所提出的研究采用了这种方法，通过在一个建立良好的非人类灵长类动物模型中对随时间变化的多级网络系统进行建模。我们预测，个体内部生物系统的协调和调节对塑造健康至关重要。 并受到个人社会关系的复杂网络结构的动态调节。

 DESCRIPTION (provided by applicant): The ability to treat and prevent illness and improve human health requires not only a detailed understanding of the complex interplay of biological systems contributing to disease processes but also the mechanisms underlying the influence of social complexity on biological systems. A developmental systems science approach provides methods uniquely suited to elucidate the mechanisms by which social systems influence health by investigating their effects on modulating the interplay among biological systems during development. The proposed research adopts this approach by modeling multi-level networked systems over time in a well-established nonhuman primate model. We predict that the coordination and regulation of biological systems within individuals are critical to shaping health trajectories and are dynamically modulated by the complex network structure of individuals' social relationships.