Effects of Altering Social Connectedness on Health

项目摘要 社交生活对健康有着深远的影响。治疗和预防疾病、改善人类健康的能力 因此，需要详细了解社会影响的复杂机制 生物系统的复杂性。这种理解是制定新的干预措施的关键 改善公共卫生。过去的研究已经证明，社会关系在 塑造健康结果，但在应用上受到限制，因为此类研究很少考虑社会支持或 健康是“复杂系统”。因此，我们缺乏对个体如何以及为什么在 家庭，以及社区内的家庭，在其社会环境中保持健康或变得不健康 环境。在这一应用中，我们建议的研究通过采用干预措施来克服这一限制- 基于实验和计算系统科学的方法，提供唯一适合于 通过模拟短期和长期来阐明社会制度影响健康的复杂机制 在已证实的非人类灵长类动物模型中，社会生活对健康的综合影响。

Project Summary Social life profoundly influences health. The ability to treat and prevent illness and improve human health therefore requires a detailed understanding of the complex mechanisms underlying the influence of social complexity on biological systems. Such understanding is key to the development of new interventions to improve public health. Past studies have demonstrated the critical contribution of social relationships in shaping health outcomes but are limited in application because such studies rarely consider social support or health as “complex systems”. As a result, we lack a deep understanding of how and why individuals within families, and families within communities, remain healthy or become unhealthy in the context of their social environments. In this application, our proposed research overcomes this limitation by adopting an intervention- based experimental and computational systems science approach that provides methods uniquely suited to elucidate the complex mechanisms by which social systems influence health by modeling short- and longer term integrative effects of social life on health in a proven nonhuman primate model.