Effects of Altering Social Connectedness on Health

项目概要 社交生活深刻影响健康。治疗和预防疾病以及改善人类健康的能力 因此，需要详细了解社会影响背后的复杂机制。 生物系统的复杂性。这种理解对于制定新的干预措施至关重要 改善公共卫生。过去的研究表明，社会关系在 塑造健康结果，但应用受到限制，因为此类研究很少考虑社会支持或 健康作为“复杂系统”。因此，我们缺乏对内部个体如何以及为何的深刻理解。 家庭以及社区内的家庭在其社会背景下保持健康或变得不健康 环境。在此应用中，我们提出的研究通过采取干预措施克服了这一限制 基于实验和计算系统的科学方法，提供了独特适合的方法 通过对短期和长期的建模来阐明社会系统影响健康的复杂机制 在经过验证的非人类灵长类动物模型中，社会生活对健康的综合影响。

Project Summary Social life profoundly influences health. The ability to treat and prevent illness and improve human health therefore requires a detailed understanding of the complex mechanisms underlying the influence of social complexity on biological systems. Such understanding is key to the development of new interventions to improve public health. Past studies have demonstrated the critical contribution of social relationships in shaping health outcomes but are limited in application because such studies rarely consider social support or health as “complex systems”. As a result, we lack a deep understanding of how and why individuals within families, and families within communities, remain healthy or become unhealthy in the context of their social environments. In this application, our proposed research overcomes this limitation by adopting an intervention- based experimental and computational systems science approach that provides methods uniquely suited to elucidate the complex mechanisms by which social systems influence health by modeling short- and longer term integrative effects of social life on health in a proven nonhuman primate model.