ECHO Coordinating Center

摘要 关于遗传和环境因素如何相互作用影响儿童健康结果，人们知之甚少。到 为了解决这些知识差距，环境对儿童健康结果的影响（ECHO）计划 承诺利用现有的儿科队列来测试环境暴露如何影响的新假设， 儿科健康杜克临床研究所（DCRI）拟担任ECHO协调机构 中心（ECHO CC）提供管理、指导和总体 协调欧共体人道处的所有共同活动。DCRI在领导这一雄心勃勃的计划方面具有独特的优势。 作为世界上最大的学术研究机构，DCRI管理着近30个活跃的网络， 行政协调中心赠款，并已成为儿科临床研究的领导者。DCRI 将利用其在更大的儿科研究界的广泛联系和网络，以及建立 与重点大学和行业合作伙伴的关系，以支持在这一服务不足的人口的研究。 DCRI的企业创造的规模经济允许使用通用的网络方法， 职能和能力，使额外的专业知识，以承担时，不可避免的问题和加速的时间表 起来。ECHO CC的总体目标是有效管理ECHO内部的合作研究 我们还需要建立基础设施，以更好地了解环境暴露对儿童健康结果的影响。到 为了实现这一愿景，欧盟总部协调中心将建立三个组成部分， ECHO内部研究设计和实施的策略：（1）指导委员会支持 该构成部分将协调欧共体人道处指导和执行委员会的所有活动并提供后勤支助 委员会、外部科学委员会、NIH ECHO团队、ECHO队列、ECHO核心、数据分析中心， 科学重点领域部分将协调共同的研究活动 通过制定全欧盟人道主义组织和特定重点领域的议定书， 程序和研究文件，以促进统一每个科学重点领域的具体成果; 以及（3）机会和基础设施基金（OIF）部分将向ECHO调查人员分配资金 推广新项目、新工具和新技术，确保项目顺利完成。 欧盟人道处协调委员会行政部门将负责监督这三个部门。ECHO CC 目标将使用DCRI内已建立的基础设施来实现，并将进行定制以满足变量 ECHO队列、指导委员会和研究者的需求。使用最高的研究标准，我们的 团队将完成NIH在管理这一至关重要的合作努力中设定的目标。

ABSTRACT Little is known about how genetic and environmental factors interact to affect child health outcomes. To address these knowledge gaps, the Environmental Influences on Child Health Outcomes (ECHO) program promises to leverage extant pediatric cohorts to test new hypotheses of how environmental exposures impact pediatric health. The Duke Clinical Research Institute (DCRI) proposes to serve as the ECHO Coordinating Center (ECHO CC) to provide the organizational framework for the management, direction, and overall coordination of all common ECHO activities. The DCRI is uniquely positioned to lead this ambitious initiative. As the world’s largest academic research organization, the DCRI manages nearly 30 active network and administrative coordinating center grants and has emerged as a leader in pediatric clinical research. The DCRI will leverage its broad contacts and networks in the larger pediatric research community, as well as established relationships with key university and industry collaborators, to support research in this underserved population. The economy of scale created by DCRI’s enterprise allows the use of common approaches to network functions and the ability to bring extra expertise to bear when inevitable problems and accelerated timelines arise. The overall goal of the ECHO CC is to efficiently manage collaborative research within the ECHO infrastructure to better understand the impact of environmental exposures on health outcomes in children. To achieve this vision, the ECHO CC will establish three components that will develop and implement innovative strategies across the design and conduct of research within ECHO: (1) the Steering Committee Support Component will coordinate and provide logistical support for all activities of the ECHO Steering and Executive Committees, External Scientific Board, NIH ECHO Team, ECHO cohorts, ECHO Cores, Data Analysis Center, and biorepositories; (2) the Scientific Focus Area Component will coordinate common research activities among the four ECHO scientific focus areas by developing ECHO-wide and focus area–specific protocols, procedures, and study documents to facilitate harmonization of outcomes specific to each scientific focus area; and (3) the Opportunities and Infrastructure Fund (OIF) Component will distribute funds to ECHO investigators to promote new projects, tools, and technologies and ensure successful completion of their projects. Overseeing all three of these components will be the ECHO CC Administrative Component. The ECHO CC goals will be met using established infrastructure within the DCRI and will be customized to meet the variable needs of the ECHO Cohorts, Steering Committee, and investigators. Using the highest research standards, our team will accomplish the goals set out by the NIH in managing this critically important collaborative effort.