Opportunities and Infrastructure Fund Component

迫切需要精心设计的研究来检验环境暴露对健康的影响 对儿童的影响。为了解决这些知识差距，环境对儿童健康的影响 结果(ECHO)计划承诺利用现有的儿科队列来测试新的假设 环境暴露影响儿科健康。杜克临床研究所(DCRI)建议 作为ECHO协调中心(ECHO CC)，为 管理、指导和全面协调所有共同的回声活动。DCRI独一无二地准备好 领导这一雄心勃勃的计划。作为世界上最大的学术研究机构，DCRI管理着近30个 积极的网络和行政协调中心的资助，并已成为儿科临床的领导者 研究。ECHO计划将建立一个机会和基础设施基金，以支持小规模的试点 项目。􀀬􀁑􀀃􀁒􀁕􀁇􀁈􀁕􀀃􀁗􀁒􀀃􀁓􀁕􀁒􀁙􀁌􀁇􀁈􀀃􀁌􀁑􀁉􀁕􀁄􀁖􀁗􀁕􀁘􀁆􀁗􀁘􀁕􀁈􀀃􀁄􀁑􀁇􀀃􀁗􀁒􀁒􀁏􀁖􀀃􀁗􀁒􀀃􀁖􀁘􀁓􀁓􀁒􀁕􀁗􀀃􀁄􀀃􀁖􀁒􀁏􀁌􀁆􀁌􀁗􀁄􀁗􀁌􀁒􀁑􀀏􀀃􀁕􀁈􀁙􀁌􀁈􀁚􀀏􀀃􀁄􀁑􀁇􀀃􀁄􀁚􀁄􀁕􀁇􀀃 􀁓􀁕􀁒􀁆􀁈􀁖􀁖􀀞􀀃􀁖􀁘􀁓􀁓􀁒􀁕􀁗􀀃􀁇􀁈􀁙􀁈􀁏􀁒􀁓􀁐􀁈􀁑􀁗􀀃􀁒􀁉􀀃􀁕􀁈􀁖􀁈􀁄􀁕􀁆􀁋􀀃􀁓􀁕􀁒􀁗􀁒􀁆􀁒􀁏􀁖􀀞􀀃􀁓􀁕􀁒􀁙􀁌􀁇􀁈􀀃􀁖􀁗􀁘􀁇􀁜􀀃􀁖􀁘􀁓􀁓􀁒􀁕􀁗􀀃􀁗􀁒􀀃􀁈􀁑􀁖􀁘􀁕􀁈􀀃􀁋􀁌􀁊􀁋􀀃􀁔􀁘􀁄􀁏􀁌􀁗􀁜􀀃 􀁖􀁗􀁘􀁇􀁜􀀃􀁒􀁓􀁈􀁕􀁄􀁗􀁌􀁒􀁑􀁖􀀃􀁄􀁑􀁇􀀃􀁗􀁌􀁐􀁈􀁏􀁜􀀃􀁆􀁒􀁐􀁓􀁏􀁈􀁗􀁌􀁒􀁑，􀁗􀁋􀁈􀀃􀀧􀀦􀀵􀀬􀀃􀁚􀁌􀁏􀁏􀀃􀁈􀁖􀁗􀁄􀁅􀁏􀁌􀁖􀁋􀀃􀁗􀁋􀁈􀀃􀀨􀀦􀀫􀀲􀀃􀀦􀀦􀀃􀀲􀁓􀁓􀁒􀁕􀁗􀁘􀁑􀁌􀁗􀁌􀁈􀁖􀀃􀁄􀁑􀁇􀀃 􀀬􀁑􀁉􀁕􀁄􀁖􀁗􀁕􀁘􀁆􀁗􀁘􀁕􀁈􀀃􀀩􀁘􀁑􀁇􀀃􀀦􀁒􀁐􀁓􀁒􀁑􀁈􀁑􀁗􀀃􀀋􀀲􀀬􀀩􀀃􀀦􀁒􀁐􀁓􀁒􀁑􀁈􀁑􀁗􀀌􀀑ECHO OIF组件将引领 ECHO OIF计划。这将得益于DCRI在1)设置以下系统方面的丰富经验 征集、收集和审查科学申请；2)实施小规模、高效的儿科研究。至 为了实现这一愿景，OIF组成部分将建立三个小组：1)研究设计小组将促进 最终确定获奖研究；2)研究指导小组将负责确保研究成果 按时并在预算内完成；以及3)行政监督小组将确保及时完成 发布ECHO品牌的MyResearchProposal门户；对所有征集、审查和 奖项；并报告关键计划指标。ECHO OIF组件将使用在 ECHO CC核心要素和科学重点领域协调(SFA)组成部分--研究启动 团队。

Well-designed research is urgently needed to examine the impact of environmental exposures on health outcomes in children. To address these knowledge gaps, the Environmental Influences on Child Health Outcomes (ECHO) program promises to leverage extant pediatric cohorts to test new hypotheses of how environmental exposures impact pediatric health. The Duke Clinical Research Institute (DCRI) proposes to serve as the ECHO Coordinating Center (ECHO CC) to provide the organizational framework for the management, direction, and overall coordination of all common ECHO activities. DCRI is uniquely poised to lead this ambitious initiative. As the world’s largest academic research organization, DCRI manages nearly 30 active network and administrative coordinating center grants and has emerged as a leader in pediatric clinical research. The ECHO Program will establish an Opportunities and Infrastructure Fund to support small, pilot projects. 􀀬􀁑􀀃􀁒􀁕􀁇􀁈􀁕􀀃􀁗􀁒􀀃􀁓􀁕􀁒􀁙􀁌􀁇􀁈􀀃􀁌􀁑􀁉􀁕􀁄􀁖􀁗􀁕􀁘􀁆􀁗􀁘􀁕􀁈􀀃􀁄􀁑􀁇􀀃􀁗􀁒􀁒􀁏􀁖􀀃􀁗􀁒􀀃􀁖􀁘􀁓􀁓􀁒􀁕􀁗􀀃􀁄􀀃􀁖􀁒􀁏􀁌􀁆􀁌􀁗􀁄􀁗􀁌􀁒􀁑􀀏􀀃􀁕􀁈􀁙􀁌􀁈􀁚􀀏􀀃􀁄􀁑􀁇􀀃􀁄􀁚􀁄􀁕􀁇􀀃 􀁓􀁕􀁒􀁆􀁈􀁖􀁖􀀞􀀃􀁖􀁘􀁓􀁓􀁒􀁕􀁗􀀃􀁇􀁈􀁙􀁈􀁏􀁒􀁓􀁐􀁈􀁑􀁗􀀃􀁒􀁉􀀃􀁕􀁈􀁖􀁈􀁄􀁕􀁆􀁋􀀃􀁓􀁕􀁒􀁗􀁒􀁆􀁒􀁏􀁖􀀞􀀃􀁓􀁕􀁒􀁙􀁌􀁇􀁈􀀃􀁖􀁗􀁘􀁇􀁜􀀃􀁖􀁘􀁓􀁓􀁒􀁕􀁗􀀃􀁗􀁒􀀃􀁈􀁑􀁖􀁘􀁕􀁈􀀃􀁋􀁌􀁊􀁋􀀃􀁔􀁘􀁄􀁏􀁌􀁗􀁜􀀃 􀁖􀁗􀁘􀁇􀁜􀀃􀁒􀁓􀁈􀁕􀁄􀁗􀁌􀁒􀁑􀁖􀀃􀁄􀁑􀁇􀀃􀁗􀁌􀁐􀁈􀁏􀁜􀀃􀁆􀁒􀁐􀁓􀁏􀁈􀁗􀁌􀁒􀁑, 􀁗􀁋􀁈􀀃􀀧􀀦􀀵􀀬􀀃􀁚􀁌􀁏􀁏􀀃􀁈􀁖􀁗􀁄􀁅􀁏􀁌􀁖􀁋􀀃􀁗􀁋􀁈􀀃􀀨􀀦􀀫􀀲􀀃􀀦􀀦􀀃􀀲􀁓􀁓􀁒􀁕􀁗􀁘􀁑􀁌􀁗􀁌􀁈􀁖􀀃􀁄􀁑􀁇􀀃 􀀬􀁑􀁉􀁕􀁄􀁖􀁗􀁕􀁘􀁆􀁗􀁘􀁕􀁈􀀃􀀩􀁘􀁑􀁇􀀃􀀦􀁒􀁐􀁓􀁒􀁑􀁈􀁑􀁗􀀃􀀋􀀲􀀬􀀩􀀃􀀦􀁒􀁐􀁓􀁒􀁑􀁈􀁑􀁗􀀌􀀑 The ECHO OIF Component will lead the development of the ECHO OIF Program. This will be facilitated by DCRI’s extensive experience in 1) setting up systems to solicit, collect and review scientific applications and 2) implementing small, efficient pediatric studies. To achieve this vision, the OIF Component will establish three Teams: 1) The Study Design Team will facilitate the finalization of awarded studies; 2) The Study Conduct Team will be responsible for ensuring study deliverables are completed on time and within budget; and 3) The Administrative Oversight Team will ensure the timely release of the ECHO branded MyResearchProposal portal; provide oversight for all solicitations, reviews, and awards; and report on key program metrics. The ECHO OIF component will use a 4th team established in the ECHO CC Core Elements and Scientific Focus Area Coordination (SFA) Component – The Study Start-up Team.