HEAL Clinical Coordinating Resource Center for the Pain Management Effectiveness Research Network

帮助结束成瘾长期(Hear)倡议是为了确定科学的解决方案 尽快应对国家阿片类公共卫生危机。作为这项倡议的一部分，美国国立卫生研究院治疗疼痛 管理有效性研究网络(Hear Pain ERN)将继续使用 NCATS试验创新网络为治愈疼痛ERN试验提供科学指导和协调。 具体来说，杜克/范德比尔特大学、犹他大学和约翰斯大学的三个试验创新中心(TIC) 霍普金斯/塔夫茨将继续为临床资源协调中心(CRCC)提供综合功能， 数据协调资源中心(DCRC)，以及用于修复的统计和安全资源中心(SSRC 疼痛ERN。将选择另外两个需要来自Hear的全力支持的Hear Pain ERN试验 疼痛ERN CCRC、DCRC和SSRRC。此外，由Hear ERN支持的五项正在进行的试验将 继续得到资源中心的专门支持。 杜克/范德比尔特试验创新中心准备： 具体目标1.提供临床试验领导和专业知识，协助研究和方案设计 与其他医疗机构ERN资源中心合作，实施和管理现有的 和新的治愈ERN试验。 具体目标2.作为现有和新的Hear ERN的临床协调资源中心(CCRC) 审判。 具体目标3.为现有和新的Hear ERN试验提供单一的IRB支持。 通过完成这些具体目标，我们将协调医疗研究，实现重大创新 在试验设计和执行方面，包括：宝贵数据的合并和再利用、执行效率、 在调查团队之间分享疼痛专业知识，并将三个抽搐整合为一个凝聚力的单位，准备就绪 以备将来试行。

The Helping to End Addiction Long-term (HEAL) initiative was developed to identify scientific solutions to the national opioid public health crisis as quickly as possible. As part of this initiative, the NIH HEAL Pain Management Effectiveness Research Network (HEAL Pain ERN) will continue to use the infrastructure of the NCATS Trial Innovation Network to provide scientific guidance and coordination of the HEAL Pain ERN Trials. Specifically, the three Trial Innovation Centers (TICs) at Duke/Vanderbilt, University of Utah, and Johns Hopkins/Tufts will continue to provide integrated functions for the clinical resource coordinating center (CRCC), data coordination resource center (DCRC), and the statistical and safety resource center (SSRC) for the HEAL Pain ERN. Two additional HEAL Pain ERN trials will be selected which will require full support from the HEAL Pain ERN CCRC, DCRC, and SSRRC. In addition, five ongoing trials supported by the HEAL ERN will continue to receive dedicated support from the resource centers. The Duke/Vanderbilt Trial Innovation Center is poised to: Specific Aim 1. Provide clinical trial leadership and expertise, assistance in study and protocol design, study implementation, and management, in collaboration with the other HEAL ERN Resource Centers, for existing and new HEAL ERN trials. Specific Aim 2. Serve as the clinical coordinating resource center (CCRC) for existing and new HEAL ERN trials. Specific Aim 3. Provide single IRB support for HEAL ERN trials for existing and new HEAL ERN trials. Through completion of these specific aims, we will harmonize the HEAL studies to achieve major innovations in trial design and execution, including: combination and reuse of valuable data, efficiencies of implementation, shared pain expertise among investigative teams, and the integration of three TICs as a cohesive unit, poised for future trial implementation.