Novel Approaches for Linking Air Quality Mixtures, Climate, and Human Health

项目摘要：城市空气污染是一个严重的公共健康问题，估计死亡率 影响主要发生在既有心血管和呼吸系统疾病的婴儿和老年人中 疾病。关于环境空气污染对健康影响的研究已经开始将研究目标从 从单一污染物范式转向更多污染物或混合物的视角，以便更好地理解 “真实世界”空气污染暴露对人类健康的影响。另一个从根本上与空气有关的领域 气候变化是人们日益关注的质量和公共卫生问题。在最初的K99阶段，我将工作 与导师密切合作，制定改进的统计方法，以评估多种污染物的影响 在流行病学研究中暴露，这是我目前博士后研究的自然延伸。我会转移注意力 从识别环境中出现的空气污染物混合物的类型到表征多污染物 用于流行病学研究的暴露。这些将应用于正在进行的两项流行病学调查。 这是在东南空气污染流行病学中心(SCAPE)内进行的；美国环保局 埃默里大学和佐治亚州研究所共同资助的清洁空气研究中心(CLARC，R834799) 技术部：短期生态研究和长期队列研究。在指导阶段，我将 开发多污染物时间剖面，用于调查与多污染物的短期关联 暴露与心肺健康结果。接下来，我将开发多污染物空间剖面图 多污染物暴露与呼吸道疾病发展的长期相关性研究 疾病。在这一阶段，我还将接受生物统计学和流行病学方法方面的新培训 在埃默里大学学习环境流行病学。在R00阶段过渡到独立 获奖后，我将把这些新技能与我的博士培训结合起来，因为我将从事专注于理解 气候对空气质量混合物的影响。我的第一个独立目标是研究气象 特定多种污染物组合的敏感性，以便更好地了解空气污染物的潜在变化 各种气候情景下的混合物。最终的拟议目标是为 人体对高温和多污染物混合物的健康脆弱性的检查。在这个奖项结束时，我 将在分析多污染物新兴研究领域的影响方面表现出专业知识 混合物和气候变化，为我作为环境健康科学家的职业生涯提供了坚实的基础 专注于流行病学研究的暴露特征。

PROJECT SUMMARY: Urban air pollution is a significant public health problem with estimated mortality impacts predominantly among infants and elderly people with pre-existing cardiovascular and respiratory disease. Research on ambient air pollution health effects has begun shifting research objectives away from the single-pollutant paradigm to a more multipollutant or mixtures perspective in order to better understand the impacts of “real world” air pollution exposures on human health. Another area that is fundamentally linked to air quality and of increasing concern for public health is climate change. During the initial K99 phase, I will work closely with mentors to develop improved statistical methodologies for assessing the effects of multipollutant exposures in epidemiological studies, a natural extension of my current postdoctoral research. I will shift focus from identifying the types of air pollutant mixtures that occur in the environment to characterizing multipollutant exposures for epidemiological research. These will be applied to two ongoing epidemiological investigations that are being conducted within the Southeastern Center for Air Pollution Epidemiology (SCAPE); a US EPA funded Clean Air Research Center (CLARC, R834799) shared between Emory University and Georgia Institute of Technology: a short-term ecological study and a long-term cohort study. During the mentored phase, I will develop multipollutant temporal profiles for the investigation of short-term associations with multipollutant exposure and cardiorespiratory health outcomes. Next, I will develop multipollutant spatial profiles for the investigation of long-term associations between multipollutant exposure and the development of respiratory disease. During this phase, I will also receive new training in biostatistical and epidemiologic methods focused on environmental epidemiology at Emory University. Transitioning to independence in the R00 phase of the award, I will merge these new skills with my PhD training as I pursue research focused on understanding the implications of climate on air quality mixtures. My first independent aim will examine the meteorological sensitivity of specific multipollutant combinations in order to better understand potential changes in air pollutant mixtures under various climate scenarios. The final proposed aim is to develop environmental profiles for the examination of human health vulnerability to heat and multipollutant mixtures. At the conclusion of this award, I will have demonstrated expertise in analyzing effects for the emerging research areas of multipollutant mixtures and climate variability, providing a firm basis for my career as an environmental health scientist focusing on exposure characterizations for epidemiological research.