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Memory Consolidation during Waking Rest

清醒休息期间的记忆巩固

基本信息

批准号：
9097933
负责人：
ERIN J WAMSLEY
金额：
$ 34.72万
依托单位：
FURMAN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-01 至 2019-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9097933
关键词：
Accounting Attention Behavior Behavioral Brain Characteristics Cognitive Collaborations Communication Conscious Consolida Data Decision Making Development Disease Electroencephalography Electrophysiology (science)Environment Eye Fostering Foundations Frequencies Functional disorder Goals Hippocampus (Brain)Hour Human Impaired cognition Knowledge Laboratories Lead Learning Memory Memory Disorders Memory Loss Methods Outcome Patients Photic Stimulation Process Public Health Research Research Technics Research Training Rest Sensory Sleep South Carolina Tars Testing Thinking Time Universities Wakefulness Work age related awake base cognitive function density long term memory medical schools memory consolidation memory process memory retention neurobehavioral neurophysiology novel strategies programs public health relevance relating to nervous system research study sensory input undergraduate student wasting

项目摘要

DESCRIPTION (provided by applicant): Sleep is an important time during which newly learned information is consolidated into a more permanent form. However, emerging evidence suggests that memory may also be consolidated during short periods of quiet waking rest interspersed throughout the day. The conditions under which this occurs remain unknown, and the neurophysiology supporting consolidation during periods of waking rest has not been described. The long- term goal of this research is to understand the cognitive function of "rest" states during wakefulness. The objective of the current project is to define the features of waking rest that contribute to its memory-enhancing effect, and to isolate the neurophysiological mechanisms responsible. Initial studies will systematically vary the behavioral features of a post-learning rest period in order to identify the characteristics accounting for its beneficial efect on memory. Preliminary data suggest that wakeful rest supports consolidation only when attention to sensory input is minimized, and in the absence of competing cognitive demands. Second, a direct comparison of rest and sleep periods following learning will assess the extent to which waking rest can produce the same memory benefits as sleep. If waking rest contributes to the consolidation of memories across the 24- hour cycle, under some conditions the memory benefit of waking rest may equal that of sleep. Finally, using high-density EEG combined with noninvasive brain stimulation techniques, this research will assess the causal contribution of resting state brain oscillations to memory consolidation. Initial experiments will establish the EEG correlates of consolidation during waking rest. Based on preliminary data, we expect that an electrophysiological signature of decreased high-frequency activity and increased slow oscillatory activity (<1Hz) will predict a superior memory outcome. The causal contribution of these neural oscillations to the consolidation process will be tested using noninvasive brain stimulation methods to manipulate resting state brain activity. The current proposal is unique in its multilevel approach to describing and manipulating resting state memory consolidation outside of sleep per se. By manipulating both behavior and neurophysiology, we will isolate the general characteristics of a neurobehavioral state that optimize memory processing. This work will enable a broader understanding of how conscious states contribute to memory consolidation, defining the necessary and sufficient conditions for consolidation to occur in wakefulness or sleep.

描述（由申请人提供）：睡眠是一个重要的时间，在此期间新学到的信息被巩固成更永久的形式。然而，新出现的证据表明，在全天短暂的安静清醒休息期间，记忆也可能得到巩固。这种情况发生的条件仍然未知，并且清醒休息期间支持巩固的神经生理学也尚未被描述。这项研究的长期目标是了解清醒期间“休息”状态的认知功能。当前项目的目标是定义有助于增强记忆效果的清醒休息的特征，并分离出负责的神经生理机制。初步研究将系统地改变学习后休息时间的行为特征，以确定其对记忆产生有益影响的特征。初步数据表明，只有当对感觉输入的注意力最小化并且没有竞争性认知需求时，清醒休息才支持巩固。其次，直接比较学习后的休息和睡眠时间将评估清醒休息在多大程度上可以产生与睡眠相同的记忆益处。如果清醒休息有助于巩固 24 小时周期内的记忆，那么在某些情况下，清醒休息对记忆的益处可能与睡眠相同。最后，这项研究将利用高密度脑电图与无创脑刺激技术相结合，评估静息状态脑振荡对记忆巩固的因果作用。初步实验将建立清醒休息期间巩固的脑电图相关性。根据初步数据，我们预计高频活动减少和慢振荡活动（<1Hz）增加的电生理学特征将预测优异的记忆结果。这些神经振荡对巩固过程的因果贡献将使用非侵入性脑刺激方法来测试，以操纵静息状态的大脑活动。目前的提案的独特之处在于其多层次的方法来描述和操作睡眠本身之外的静息状态记忆巩固。通过操纵行为和神经生理学，我们将分离出优化记忆处理的神经行为状态的一般特征。这项工作将使人们更广泛地了解意识状态如何促进记忆巩固，定义清醒或睡眠时巩固发生的必要和充分条件。