FASEB SRC on Trace Elements in Biology and Medicine

 描述(由申请人提供)： 2016年FASEB关于生物和医学中微量元素的会议将于2016年6月5日至10日在蒙大拿州博兹曼郊外的大天空会议中心举行。这是最早的SRC之一，自1983年以来每两年举行一次会议，这是现在规模更大的专注于生物学中金属这一广泛主题的会议中的第一个。SRC与其他研究中心(如GRC“生物学中的金属”和“金属细胞生物学”)的不同之处在于，它侧重于铁(Fe)、铜(Cu)、锌(Zn)、锰(Mn)和硒(Se)等必需的微量营养素如何促进人类与生物圈之间的生理相互作用，例如人类作为细菌和真菌病原体的宿主；金属和代谢疾病，如糖尿病和呼吸功能障碍；金属和蛋白质聚集相关的神经变性。这种影响的广度反映在所描述的科学计划的广度上，以及将被召集在一起的PI及其受训人员。该计划将涵盖一系列科学兴趣，从发育生物学、遗传学和生物化学，到化学、营养和临床医学。课程主题将包括微生物、植物和包括人类在内的高等真核生物中的微量元素摄取、运输和调节；微量元素在免疫和代谢紊乱中的作用；金属在神经退化中的作用。将讨论用于监测细胞中痕量元素的尖端技术。这一系列会议的一个显著优势是，它能够将专注于微量元素新陈代谢分子细节的研究科学家与研究微量元素对人类健康、营养和疾病的直接影响的科学家-临床医生联系起来；在这个词成为热门话题之前，这个会议一直是“翻译的”。最后，SRC的主要目标一直是提供一个论坛，让受训者和新的调查人员可以磨练他们的技能和资历，使他们在未来几十年接管“痕量元素”领域的领导。我们将把现有的研究人员和实习生聚集在一起，以促进沟通、指导和合作。这一系列会议的最终目标是促进针对人类疾病和紊乱的新治疗干预措施的持续发展，至少部分反映与微量元素新陈代谢有关的病理生理学。

 DESCRIPTION (provided by applicant): The 2016 FASEB Conference on Trace Elements in Biology and Medicine will take place at the Big Sky Conference Center, outside of Bozeman, MT, June 5-10, 2016. This is one of the original SRCs, meeting biennially since 1983, the first of the now larger group of conferences that focus on the broad subject of metals in biology. What distinguishes this SRC from these others (e.g. GRC "Metals in Biology" and "Cell Biology of Metals") is its focus on how essential micronutrients such as iron (Fe), copper (Cu), zinc (Zn), manganese (Mn) and selenium (Se) contribute to the physiologic interaction between humans and the biosphere, e.g. humans as hosts for bacterial and fungal pathogens; metals and metabolic disorders such as diabetics and respiratory dysfunction; metals and protein aggregation-associated neurodegeneration. This breadth of impact is reflected in the breadth of the scientific program described and the PIs and their trainees who will be brought together. The program will span a range of scientific interests from developmental biology, genetics, and biochemistry, to chemistry, nutrition, and clinical medicine. Session topics will cover trace element uptake, trafficking, and regulation in microorganisms, plants, and higher eukaryotes including humans; the role of trace elements in immunity and metabolic disorders; metals in neurodegeneration. Cutting-edge techniques useful in monitoring trace elements in cells will be discussed. A notable strength of this conference series has been its ability to unite research scientists focused on the molecular details of trace element metabolism with scientist-clinicians studying the direct impact of trace elements on human health, nutrition, and disease; this Conference has been "translational" before the word became topical. Last, a primary aim of this SRC has always been to provide a forum in which trainees and new investigators can hone their skills and credentials, positioning them to take over leadership of the "Trace Elements" field in the coming decades. We will be bringing together established investigators and trainees to promote communication, mentoring, and collaborations. The ultimate goal of this conference series is to foster the ongoing development of new therapeutic interventions with respect to human diseases and disorders that, at least in part, reflect a pathophysiology related to trace element metabolism.