Representation and Binding of Spatial and Temporal Episodic Memories in Human Hippocampus

人类海马体时空情景记忆的表征和结合

基本信息

  • 批准号:
    9084639
  • 负责人:
  • 金额:
    $ 32.08万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-07-01 至 2018-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The goal of this project is to determine the neural basis of human episodic memory using an innovative combination of high-resolution functional magnetic resonance imaging (fMRI) and intracranial EEG (iEEG). Episodic memory involves knowing where and when an event occurred relative to other events, both of which depend critically on the hippocampus. Yet exactly how and in what manner the hippocampus codes spatial and temporal aspects of episodic memory remains unclear and understudied, particularly in humans where the primary focus of research has been on verbal episodic memory. Using a newly developed experimental paradigm from our lab, we will study the spatial and temporal components of episodic memory, focusing on two critical processes underlying these components: representation and binding. To map these onto the hippocampal circuit, we employ high-resolution fMRI. In contrast to some previous models developed in the rodent, we hypothesize that spatio-temporal representation is a function shared across hippocampal subregions but that subregion CA3/DG plays a distinct role in parsing elements of context to represent an episode. We further hypothesize a central role for hippocampal subregion CA1 in spatio-temporal binding based on its unique connectivity, in contrast to previous models that have focused on CA3/DG. Collaborating with a team of neurologists and neurosurgeons at two different hospitals, we will also employ iEEG in patients undergoing seizure monitoring. This complementary approach will allow us to determine a separate yet critical component of episodic memory: how does coordinated neural activity in the hippocampus, long linked with spatial navigation in the rodent but understudied in humans, underlie representation and binding of spatio-temporal memory? Overall, our proposed experiments will provide novel insight into the neural basis of episodic memory as they take a new approach to this issue paradigmatically and methodologically and allow us to test several different models of hippocampal function, including our model. Neurodegenerative diseases such as stroke, epilepsy, and schizophrenia impact hippocampal subregion function and coordinated neural activity there, often resulting in symptoms of spatial disorientation and temporal confusion in patients afflicted with these conditions. Our approach thus will also have significant implications for neural diseases that affect the hippocampus.
描述(由申请人提供):该项目的目标是利用高分辨率功能磁共振成像(fMRI)和颅内脑电图(iEEG)的创新组合来确定人类情景记忆的神经基础。情景记忆涉及了解一个事件相对于其他事件发生的地点和时间,这两者都严重依赖于海马体。然而,海马体究竟如何以及以何种方式编码情景记忆的空间和时间方面仍然不清楚,也没有得到充分研究,特别是在人类中,研究的主要焦点一直是言语情景记忆。使用我们实验室新开发的实验范式,我们将研究情景记忆的空间和时间组成部分,重点关注这些组成部分背后的两个关键过程:表征和绑定。为了将这些映射到海马回路上,我们采用了高分辨率功能磁共振成像。与之前在啮齿动物中开发的一些模型相比,我们假设时空表征是海马亚区共享的功能,但 CA3/DG 亚区在解析上下文元素以表示事件方面发挥着独特的作用。与之前关注 CA3/DG 的模型相比,我们基于其独特的连接性进一步假设海马亚区 CA1 在时空结合中的核心作用。我们还将与两家不同医院的神经科医生和神经外科医生团队合作,对接受癫痫发作监测的患者使用 iEEG。这种互补的方法将使我们能够确定情景记忆的一个独立但关键的组成部分:海马体中协调的神经活动如何构成时空记忆的表征和结合的基础?海马体长期与啮齿动物的空间导航相关,但在人类中尚未得到充分研究?总的来说,我们提出的实验将为情景记忆的神经基础提供新的见解,因为他们在范式和方法论上采取了新的方法来解决这个问题,并使我们能够测试几种不同的海马功能模型,包括我们的模型。中风、癫痫和精神分裂症等神经退行性疾病会影响海马分区的功能和协调的神经活动,常常导致患有这些疾病的患者出现空间定向障碍和时间混乱的症状。因此,我们的方法也将对影响海马体的神经疾病产生重大影响。

项目成果

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ARNE D EKSTROM其他文献

ARNE D EKSTROM的其他文献

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{{ truncateString('ARNE D EKSTROM', 18)}}的其他基金

A neurocomputational model of age-related differences in navigation.
与年龄相关的导航差异的神经计算模型。
  • 批准号:
    10644265
  • 财政年份:
    2023
  • 资助金额:
    $ 32.08万
  • 项目类别:
Characterizing the cognitive computations underlying spatial navigation
表征空间导航基础的认知计算
  • 批准号:
    10726662
  • 财政年份:
    2023
  • 资助金额:
    $ 32.08万
  • 项目类别:
Precision and binding as two dimensions of medial temporal lobe amnesia
内侧颞叶遗忘症二维的精确性和结合力
  • 批准号:
    10398901
  • 财政年份:
    2020
  • 资助金额:
    $ 32.08万
  • 项目类别:
Precision and binding as two dimensions of medial temporal lobe amnesia
内侧颞叶遗忘症二维的精确性和结合力
  • 批准号:
    10178134
  • 财政年份:
    2020
  • 资助金额:
    $ 32.08万
  • 项目类别:
Precision and binding as two dimensions of medial temporal lobe amnesia
内侧颞叶遗忘症二维的精确性和结合力
  • 批准号:
    10058566
  • 财政年份:
    2020
  • 资助金额:
    $ 32.08万
  • 项目类别:
Precision and binding as two dimensions of medial temporal lobe amnesia
内侧颞叶遗忘症二维的精确性和结合力
  • 批准号:
    10617720
  • 财政年份:
    2020
  • 资助金额:
    $ 32.08万
  • 项目类别:
Volumetric and connectivity measures of navigation and memory skill acquisition
导航和记忆技能获取的体积和连接性测量
  • 批准号:
    10115363
  • 财政年份:
    2020
  • 资助金额:
    $ 32.08万
  • 项目类别:
Testing a Novel Theoretical Framework for the Human Medial Temporal Lobes in Perception and Memory During Spatial Navigation
测试人类内侧颞叶在空间导航过程中感知和记忆的新理论框架
  • 批准号:
    9102285
  • 财政年份:
    2015
  • 资助金额:
    $ 32.08万
  • 项目类别:
Testing a Novel Theoretical Framework for the Human Medial Temporal Lobes in Perception and Memory During Spatial Navigation
测试人类内侧颞叶在空间导航过程中感知和记忆的新理论框架
  • 批准号:
    8949358
  • 财政年份:
    2015
  • 资助金额:
    $ 32.08万
  • 项目类别:
Mapping Human Memory with Electrocorticography & Chronometric Stimulation
用皮层电图绘制人类记忆
  • 批准号:
    8824066
  • 财政年份:
    2014
  • 资助金额:
    $ 32.08万
  • 项目类别:

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