University of New Mexico (UNM) Center for Brain Recovery and Repair

新墨西哥大学 (UNM) 脑恢复和修复中心

• 批准号: 8813360
• 负责人: Claude W Shuttleworth
• 金额: $ 243.9万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8813360
• 关键词: Accident and Emergency department; Acute Brain Injuries; Address; Adoption; Animal Model; Area; Award; Basic Science; Brain; Brain Injuries; Cell Nucleus; Clinical; Clinical Investigator; Clinical Research; Cognitive; Communities; Consultations; Core Facility; Development; Disease; Ensure; Equipment; Extramural Activities; Faculty; Family; Fostering; Funding; Future; Goals; Grant; Growth; Health; Home environment; Hospitals; Housing; Individual; Injury; Intensive Care Units; Intervention; Laboratories; Lead; Leadership; Life; Mentors; Methods; Mexican; Motor; Nervous system structure; New Mexico; Occupational Therapy; Outcome; Pathway interactions; Patients; Phase; Physical therapy; Population; Positioning Attribute; Process; Quality of life; Recovery; Recovery of Function; Research; Research Infrastructure; Research Personnel; Resource Sharing; Resources; Stroke; Structure; Survivors; Symptoms; Technical Expertise; Time; Training; Trauma; Traumatic Brain Injury; United States National Institutes of Health; Universities; Work; base; behavioral health; brain circuitry; brain repair; career development; clinical application; cognitive control; cognitive function; cohort; collaborative environment; community living; cost; cost effective; disability; effective intervention; effective therapy; efficacy testing; experience; health disparity; human subject; improved; mortality; patient advocacy group; personalized intervention; pre-clinical; prevent; programs; public health relevance; repaired; research and development; therapy design/development; therapy development; trauma centers

 DESCRIPTION (provided by applicant): Survivors of brain injuries such as stroke and trauma often endure life-long disabilities, which span a spectrum of deficits and which are associated with enormous individual and societal costs. There is an urgent need to develop effective interventions that can improve cognitive and motor function, as well as methods that can track individual recovery paths to begin to personalize intervention for the range of symptoms the follow brain injury. Especially critical are approaches that can be applied in the months and years after the injury, as patients are attempting to reintegrate into normal daily life. The Cente for Brain Recovery and Repair will develop an interdisciplinary community of investigators focused on addressing this issue. The Center will bring together a critical mass of investigators from different departments and programs, and provide them with centralized facilities and resources needed to work together on interventions that promote cellular repair of damaged brain, and promote recovery of function. Established investigators from within UNM, together with key external scientific consultants and leadership from community brain injury programs will provide a nucleus of intellectual and technical expertise, and contribute to the development of a cohort of the most promising junior faculty in this field. The Center will focus on moving laboratory discoveries about brain repair mechanisms into clinical application, and is therefore structured to promote extensive interaction between preclinical and clinical investigators. Key resources that are currently lacking will be established, including core facilities with cutting ede facilities for clinical and preclinical interventions and assessments. Investigators will be also b provided with access to other existing facilities and training that can improve their studies and career development. Achieving these aims is expected to lead to development of extramural funding of multiple new programs, including first R01s for junior faculty, and new collaborative awards to teams of established investigators in the Center. These will include future program grants from other NIH centers which, together with strong institutional support, will maintain growth of the Center beyond the period of the current award. Significantly enhanced research capabilities will also be available for a larger constituency of brain and behavioral health investigators in New Mexico, and investigators in other IDeA states. Such outcomes are expected to have an important positive impact, as they will greatly accelerate the discovery and adoption of interventions that are urgently needed for large numbers of individuals in IDeA communities living with the devastating consequences of brain injury.

 描述(申请人提供)：中风和创伤等脑损伤的幸存者通常遭受终身残疾，这种残疾跨越了一系列缺陷，并与巨大的个人和社会成本有关。迫切需要开发能够改善认知和运动功能的有效干预措施，以及能够跟踪个人康复路径的方法，以便开始对脑损伤后的一系列症状进行个性化干预。尤其关键的是可以在受伤后的几个月和几年内应用的方法，因为患者正试图重新融入正常的日常生活。大脑恢复和修复中心将建立一个跨学科的研究人员社区，专注于解决这一问题。该中心将汇集来自不同部门和项目的大量研究人员，并为他们提供集中的设施和资源，以共同努力进行干预，促进受损大脑的细胞修复，促进功能恢复。来自UNM内部的资深调查人员，以及来自社区脑损伤项目的关键外部科学顾问和领导层，将提供核心的智力和技术专业知识，并为该领域最有前途的初级教员队伍的发展做出贡献。该中心将专注于将有关大脑修复机制的实验室发现转化为临床应用，因此其结构旨在促进临床前和临床研究人员之间的广泛互动。将建立目前缺乏的关键资源，包括具有尖端EDE设施的核心设施，用于临床和临床前干预和评估。调查人员还将获得可改善其学习和职业发展的其他现有设施和培训。实现这些目标预计将导致多个新项目的外部资金的发展，包括为初级教师提供的第一个R01，以及向该中心的知名研究人员团队提供新的合作奖项。这些将包括来自其他NIH中心的未来计划赠款，加上强有力的机构支持，将在当前奖励期限后保持该中心的增长。显著增强的研究能力也将适用于新墨西哥州更多的大脑和行为健康研究人员，以及其他IDEA州的研究人员。这些结果预计将产生重要的积极影响，因为它们将极大地加速发现和采用干预措施，而这些干预措施对于生活在脑损伤破坏性后果中的大量理想社区个人来说是迫切需要的。