Liver Cancer (LC) (Project-003)

肝癌 (LC)（项目-003）

• 批准号: 8932193
• 负责人: SCOTT L. FRIEDMAN
• 金额: $ 0.66万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8932193
• 关键词: Address; Alcoholic Liver Diseases; Award; Basic Science; Biliary; Cancer Center Support Grant; Cancer Research Project; Caring; Chronic; Classification; Clinical; Clinical Research; Clinical Trials; Communities; Community Outreach; Data; Development; Diagnosis; Disease; Enrollment; Epigenetic Process; Fatty Liver; Fibrosis; Genomics; Goals; Hepatic; Hepatitis; Hepatitis B Virus; Hepatitis C virus; Hepatocarcinogenesis; Inflammation; Institutes; Intervention; Intrahepatic Cholangiocarcinoma; Investigation; Laboratory Study; Lead; Link; Liver; Liver Fibrosis; Liver diseases; Malignant Neoplasms; Malignant neoplasm of liver; Modeling; Molecular; Molecular Diagnosis; Mus; Newly Diagnosed; Operative Surgical Procedures; Pathogenesis; Patients; Peer Review; Positioning Attribute; Preventive; Primary carcinoma of the liver cells; Proteomics; Publishing; Randomized; Reporting; Research Personnel; Risk; Scientist; Serum; Signal Pathway; Stratification; Testing; Therapeutic; Tissues; Translating; Translational Research; Underserved Population; United States; Viral hepatitis; Zebrafish; abstracting; base; chronic liver disease; efficacy testing; improved; innovation; member; multidisciplinary; novel; novel strategies; outreach program; personalized medicine; pre-clinical; preclinical study; programs; screening; translational study

ABSTRACT – LIVER CANCER (LC) RESEARCH PROGRAM Program Leaders: Scott Friedman, MD and Josep Llovet, MD The Liver Cancer (LC) Program is a comprehensive multidisciplinary program that incorporates all aspects of the disease from community screening to fundamental mechanisms of heptocarcinogenesis in both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). The objectives of this program are to: 1) Elucidate fundamental mechanisms underlying the basis of how chronic liver or biliary disease and fibrosis precipitously increase the risk of HCC and ICC; 2) Translate these fundamental advances into novel approaches to the diagnosis and molecular stratification of HCC and ICC; 3) Test the efficacy of these novel interventions in investigator-initiated, early clinical proof-of concept trials and subsequently in pivotal randomized studies. The themes that have developed from this focus are: 1) Basic mechanisms of chronic hepatic inflammation that lead to HCC; 2) Molecular and cellular basis of hepatic fibrosis and HCC; 2) Novel models and pre-clinical studies of HCC pathogenesis and treatment; 3) Innovative therapeutic pre-clinical and clinical strategies for liver cancer (HCC and ICC). Highlights of the program include: a) Established comprehensive community outreach programs devoted to screening for chronic liver disease among underserved populations, linked to care for newly diagnosed liver disease; b) Unique clinical expertise in the preventive management of patients with chronic liver disease through hepatitis treatments and surgical care of HCC; c) A basic and translational research program that is redefining the molecular classification of HCC and ICC; d) A fruitful HCC tissue and serum bank that provides Mount Sinai scientists and investigators throughout the world with unique sets of genomic, proteomic and epigenetic data; e) A robust clinical trials program in HCC and ICC that has led the United States in enrollment in HCC clinical trials. The program is uniquely positioned to achieve its long-term goal to generate groundbreaking advances in understanding mechanisms of HCC and ICC, and to apply these towards the development and early testing of novel, personalized therapies that will improve the outlook for patients with these catastrophic malignancies The LC program has 24 members, and they represent 10 departments and 6 institutes. As of July 1, 2014, program members were awarded $3,124,363 in NCI and other peer-reviewed cancer-related direct support. Since 2011, LC program members published 220 reports, of which 28.6% were intra-programmatic and 8.2% inter-programmatic.

摘要 – 肝癌 (LC) 研究计划 项目负责人：医学博士 Scott Friedman 和医学博士 Josep Llovet 肝癌 (LC) 计划是一项综合性多学科计划，涵盖了肝癌的各个方面 从社区筛查到肝癌发生的基本机制的疾病 肝细胞癌（HCC）和肝内胆管癌（ICC）。该计划的目标 目的是： 1) 阐明慢性肝脏或胆道疾病如何和 纤维化急剧增加 HCC 和 ICC 的风险； 2）将这些基础性进展转化为新颖的 HCC 和 ICC 的诊断和分子分层方法； 3）测试这些新颖的功效 对研究者发起的早期临床概念验证试验以及随后的关键试验进行干预 随机研究。 由此产生的主题是：1）慢性肝脏炎症的基本机制 导致 HCC； 2）肝纤维化和HCC的分子和细胞基础； 2）新颖模型和临床前 HCC发病机制和治疗研究； 3）创新的临床前和临床治疗策略 肝癌（HCC 和 ICC）。该计划的亮点包括： a) 建立综合社区 致力于在服务不足的人群中筛查慢性肝病的外展计划，与 护理新诊断的肝病； b) 在患者预防管理方面独特的临床专业知识 通过肝炎治疗和 HCC 手术治疗患有慢性肝病； c) 基础和翻译 重新定义 HCC 和 ICC 分子分类的研究计划； d) 丰富的 HCC 组织和 血清库为世界各地的西奈山科学家和研究人员提供独特的血清库 基因组、蛋白质组和表观遗传学数据； e) 强有力的 HCC 和 ICC 临床试验计划，引领了 美国正在开展 HCC 临床试验。该计划具有独特的定位，可以实现其长期目标 目标是在理解 HCC 和 ICC 机制方面取得突破性进展，并应用这些成果 致力于开发和早期测试新颖的个性化疗法，这将改善治疗的前景 患有这些灾难性恶性肿瘤的患者 LC项目有24名成员，分别代表10个院系和6个研究所。截至 2014 年 7 月 1 日， 项目成员获得了 3,124,363 美元的 NCI 和其他经过同行评审的癌症相关直接支持。 自 2011 年以来，LC 计划成员发布了 220 份报告，其中 28.6% 是计划内报告和 8.2% 跨项目。