Training Program in Investigative Gastroenterology and Hepatology

胃肠病学和肝病学研究培训计划

• 批准号: 10628499
• 负责人: SCOTT L. FRIEDMAN
• 金额: $ 26.83万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628499
• 关键词: Gastroenterology; Hepatology; Training Programs

The burden of digestive diseases in the United States is staggering, with annual costs exceeding $140 billion, based on National Institutes of Health (NIH) estimates. To meet this challenge, a key mission of the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK) is to support the training of a talented, diverse pool of young investigators who will attack scientific unmet needs to improve the lives of patients with gastrointestinal and liver diseases. The Icahn School of Medicine at Mount Sinai (ISMMS) has been a center of excellence for care in gastrointestinal and liver diseases for decades, with clinical fellowship programs in these disciplines consistently ranked among the best in the country. Moreover, ISMMS offers a fertile environment from which a cadre of outstanding candidates have launched successful careers in academic gastroenterology and hepatology. The overarching goal of this Training Program proposal is to leverage this outstanding environment to support the training of M.D., M.D./Ph.D or Ph.D. postdoctoral fellows by providing exceptional research opportunities and mentorship in three broad areas: A) Gastrointestinal inflammation and the microbiome; B) Non-alcoholic steatohepatitis (NASH), hepatic inflammation and fibrosis; and C) Genetics of gastrointestinal and liver diseases. The highly structured training program provides a tailored curriculum that integrates clinico-epidemiologic-, genetic-, environmental- and cellular/molecular research excellence. The program is built upon a foundation of world class research faculty who have outstanding track records of academic achievement and successful mentorship. The curriculum focuses on cross-disciplinary training in order to prepare trainees for the current and future challenges of gastrointestinal and liver disease research, which now requires integration of complementary research skill sets. To address this need, a highly selected pool of mentors has been chosen not only from within the Divisions of GI and Liver Diseases and other clinical disciplines, but who also represent outstanding multi-disciplinary institutes at the ISMMS. Each year this program will support 3 trainees (PGY 4 - PGY 6), with 15 candidates entering the program over 5 years. Each trainee will pursue an individualized research project and tailored curriculum formulated together with their primary and secondary mentors, curriculum committee and the Program Directors. Trainees will dedicate at least 90% effort in either the laboratory or clinical setting, and their progress will be monitored through quarterly meetings with their advisory committee and program directors. Overall quality and adaptability of the program will be ensured through oversight by internal and external advisory boards, based on compliance with defined metrics of success for both individual trainees and the overall program. This rigorously structured and closely monitored program, committed to excellence and built upon a rich scientific environment and outstanding faculty, will yield superbly trained future leaders in investigative gastroenterology and hepatology.

美国消化系统疾病的负担令人震惊，每年的成本超过1400亿美元， 根据美国国立卫生研究院(NIH)的估计。为了迎接这一挑战，国家统计局的一项关键使命 糖尿病和消化与肾脏疾病研究所(NIDDK)是支持培养人才的、多样化的 一群年轻的研究人员，他们将攻击科学上未得到满足的需求，以改善患者的生活 胃肠道和肝脏疾病。 西奈山伊坎医学院(ISMMS)一直是胃肠道护理的卓越中心 和肝脏疾病，这些学科的临床奖学金项目一直位居 全国最好的。此外，ISMMS提供了一个肥沃的环境，使优秀的 应聘者已经在学术胃肠病学和肝病学领域取得了成功。最重要的是 本培训计划提案的目标是利用这一出色的环境来支持 医学博士、医学博士/博士或博士后研究员，通过提供特殊的研究机会和指导 在三大领域：A)胃肠道炎症和微生物群；B)非酒精性脂肪性肝炎 非酒精性肝病(NASH)、肝脏炎症和纤维化；以及C)胃肠道和肝脏疾病遗传学。高度的 结构化培训计划提供量身定制的课程，将临床流行病学、遗传学、 卓越的环境和细胞/分子研究。该计划建立在世界级的基础上 在学术成就和成功指导方面有突出记录的研究人员。这个 课程侧重于跨学科培训，以使受训者为当前和未来的挑战做好准备 胃肠道和肝病研究，现在需要整合互补的研究技能 布景。为了满足这一需求，不仅从各部门内部挑选了一批经过高度挑选的导师 胃肠病、肝病和其他临床学科，但也代表了杰出的多学科 ISMMS的研究所。 该计划每年将支持3名学员(PGY 4-PGY 6)，15名候选人将进入该计划 五年了。每个学员都将进行个性化的研究项目和共同制定的量身定制的课程 与他们的小学和中学导师，课程委员会和项目主任。实习生将 在实验室或临床环境中至少付出90%的努力，他们的进展将通过 与他们的顾问委员会和项目主管举行季度会议。综合素质和适应能力 计划将通过内部和外部咨询委员会的监督来确保，基于遵守 为个别受训人员和整个计划确定了成功的衡量标准。这是一部结构严谨、 严密监控计划，致力于卓越，建立在丰富的科学环境和卓越的基础上 将培养出训练有素的未来研究胃肠病学和肝脏病学的领导者。