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High-throughput screens for compounds that reverse cellular toxicity of neurodegenerative disease-associated proteins in yeast models (alpha-synuclein)

High-throughput screens for compounds that reverse cellular toxicity of neurodegenerative disease-associated proteins in yeast models (alpha-synuclein)
高通量筛选可逆转酵母模型中神经退行性疾病相关蛋白（α-突触核蛋白）细胞毒性的化合物
批准号：
9205648
负责人：
Marc Ferrer
金额：
$1.9万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/9205648
关键词：
throughputscreenscompoundsreversecellular

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中文摘要
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英文摘要
During this period, the NCGC has fostered and maintained over 180 active collaborations with both NIH and extramural investigators, facilitating drug discovery efforts across the entire spectrum of human disease. These efforts have led to over 100 high-throughput screens and nearly 60 medicinal chemistry campaigns, providing our collaborators and the general research community a wealth of publications and promising small molecule leads. In addition, the NCGC has undertaken a number of informatic challenges to make better use of existing drug and disease target information and provide the general public with easily accessible resources, further catalyzing the development of new therapies for human disease.
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