Targeting Tumor-derived exRNA-Containing microvesicles by high throughput screening

通过高通量筛选靶向肿瘤来源的含有 exRNA 的微泡

• 批准号: 9359917
• 负责人: Marc Ferrer
• 金额: $ 15.8万
• 依托单位: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9359917
• 关键词: Adipose tissue; Biological Assay; Biology; Cancer Patient; Cells; Chemicals; Collaborations; Communities; Data; Development; Disease; Extramural Activities; Fostering; General Population; Genomics; Goals; Informatics; Lead; MicroRNAs; Modeling; Neoplasm Metastasis; Neoplastic Cell Transformation; Obesity; Oncogenic; Patients; Pharmaceutical Chemistry; Pharmaceutical Preparations; Process; Publications; RNA; Recruitment Activity; Research; Research Personnel; Resources; Stem cells; Synthesis Chemistry; Tumor-Derived; United States National Institutes of Health; Validation; Work; assay development; base; castration resistant prostate cancer; drug development; drug discovery; high throughput screening; human disease; improved; in vivo; microvesicles; neoplastic cell; new technology; novel therapeutics; screening; small molecule; small molecule therapeutics; therapeutic development; tool; tumor; tumor growth; uptake

As a center, the NCGC has fostered and maintained over 110 active collaborations with both NIH and extramural investigators, facilitating drug discovery efforts across the entire spectrum of human disease. These efforts have led to dozens of high-throughput screens and a number of medicinal chemistry campaigns to further improve on screening hits, providing our collaborators and the general research community with publications and a variety of promising small molecule probes and leads. In addition, the NCGC has worked to advance a number of informatic initiatives to make better use of existing drug and disease target information and provide the general public with easily accessible resources, further catalyzing the development of new therapies for human disease.

作为一个研究中心，NCGC与NIH和校外研究人员建立并保持了110多个积极的合作关系，促进了整个人类疾病领域的药物发现工作。这些努力已经导致了数十种高通量筛选和许多药物化学活动，以进一步提高筛选命中值，为我们的合作者和一般研究界提供出版物和各种有前途的小分子探针和先导物。此外，NCGC还努力推进一些信息学倡议，以便更好地利用现有药物和疾病目标信息，并向公众提供易于获取的资源，进一步促进人类疾病新疗法的发展。