A Twin Study of Chronic Back Pain and Associated Disability in Veterans

退伍军人慢性背痛和相关残疾的双胞胎研究

基本信息

  • 批准号:
    9172623
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-10-01 至 2019-09-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION: Pain management has been identified as a priority area in VA clinical care, and chronic back pain is a leading cause of disability for US veterans. The role in back pain of psychiatric disorders such as post- traumatic stress disorder (PTSD) has not been well studied in Veterans. For example, while there is a high co-occurrence of PTSD with chronic pain in Veterans, it remains unknown whether PTSD is a risk factor for the development of pain, or whether this co-occurrence is due to other factors such as shared familial predispositions. In addition, there have been no studies to date examining the genomics of back pain in Veterans. We propose a study of back pain in older Veterans who are members of the Vietnam Era Twin (VET) Registry. The Registry is comprised of 7369 male-male twin pairs, both of whom served in the military during the Vietnam conflict (1964-1975). We will capitalize on the rich data available in the Registry, and the recently completed study entitled, 'CSP 569: A Twin Study of the Course and Consequences of PTSD in Vietnam Era Veterans'. Our project consists of 3 interrelated components. First, we will analyze detailed information on PTSD and back pain from amongst the 7332 veterans who participated in CSP 569. Second, we will follow 171 MZ twin pairs who are discordant for PTSD symptoms, but are concordant for absence of back pain at baseline, for the occurrence of back pain. The longitudinal MZ co-twin design allows examination of the effect of an exposure while controlling for shared genetics and family environment. Third, we will conduct an epigenome-wide association study (EWAS) identifying differentially methylated regions (DMRs) associated with prevalent chronic back pain and back pain risk factors using recently acquired biospecimens from the VET Registry Biorepository. We will further cross-reference identified DMRs with existing databases of genes associated with known pain mechanisms, and conduct pathway analyses to identify specific biological networks which may be implicated in the production of pain. The candidate, Dr. Pradeep Suriyaarachchi, MD, MS is a physiatrist with subspecialty training in Pain Medicine and clinical expertise in back pain management. His career goal is to become an independent VA Investigator conducting epidemiologic research focused on the prevention of back pain, and improving function for Veterans with chronic back pain. His background is in clinical epidemiology, but he seeks to gain training in contemporary genetic epidemiology, genomics, and bioinformatics, in order to gain insights into the etiology of back pain, and to develop new interventions for back pain and related disability. He has assembled an outstanding mentorship team under the leadership of primary mentor Dr. Edward Boyko, MD, MPH. This mentorship team includes renowned experts in clinical epidemiology, genetic epidemiology, genomics, and bioinformatics, as well as the clinical domains of back pain and rehabilitation. The CDA-2 will allow Dr. Suriyaarachchi the structured coursework, mentorship, and applied learning needed to acquire new research skills in genetic epidemiology and genomics. Structured learning experiences will include formal coursework and seminars, regular local conferences, and attendance at scientific meetings. He will take advantage of key local resources to carry out the proposed research and training in the centers where his mentors are based, including the VA Seattle Epidemiologic Research and Information Center (where he is an investigator), the VET Registry, and the University of Washington's Department of Genome Sciences and Comparative Effectiveness, Cost, and Outcomes Research Center (which specializes in back pain research). This outstanding local environment will help ensure Dr. Suriyaarachchi's success.
产品说明: 疼痛管理已被确定为VA临床护理的优先领域,慢性背痛是美国退伍军人残疾的主要原因。精神疾病如创伤后应激障碍(PTSD)在退伍军人背痛中的作用还没有得到很好的研究。例如,虽然在退伍军人中PTSD与慢性疼痛的共同发生率很高,但仍不清楚PTSD是否是疼痛发展的风险因素,或者这种共同发生是否是由于其他因素,如共同的家族倾向。此外,迄今为止还没有研究检查退伍军人背痛的基因组学。我们提出了一项研究的背痛在老年退伍军人谁是越南时代双胞胎(VET)注册表的成员。该登记册由7369对男性双胞胎组成,他们都在越南战争期间(1964-1975)服役。我们将利用登记处提供的丰富数据,以及最近完成的题为“CSP 569:越南时代退伍军人创伤后应激障碍的过程和后果的双胞胎研究”的研究。我们的项目由三个相互关联的部分组成。首先,我们将分析参加CSP 569的7332名退伍军人中有关PTSD和背痛的详细信息。第二,我们将跟踪171对MZ双胞胎,他们在PTSD症状上不一致,但在基线时没有背痛,背痛的发生率是一致的。纵向MZ共双胞胎设计允许检查暴露的影响,同时控制共享的遗传学和家庭环境。第三,我们将进行一项表观全基因组关联研究(EWAS),使用最近从VET注册生物储存库获得的生物标本,鉴定与流行慢性背痛和背痛风险因素相关的差异甲基化区域(DMR)。我们将进一步交叉引用已确定的DMR与已知疼痛机制相关的基因的现有数据库,并进行通路分析,以确定可能与疼痛产生有关的特定生物网络。候选人Pradeep Suriyaarachchi博士,医学博士,MS是一名理疗师,接受过疼痛医学的亚专业培训,并拥有背痛管理的临床专业知识。他的职业目标是成为一名独立的VA调查员,进行流行病学研究,重点是预防背痛,并改善慢性背痛退伍军人的功能。他的背景是临床流行病学,但他寻求获得当代遗传流行病学,基因组学和生物信息学的培训,以深入了解背痛的病因,并为背痛和相关残疾开发新的干预措施。他在主要导师Edward Boyko博士(医学博士,公共卫生硕士)的领导下组建了一支杰出的导师团队。该指导团队包括临床流行病学,遗传流行病学,基因组学和生物信息学以及背痛和康复临床领域的知名专家。CDA-2将使Suriyaarachchi博士获得获得遗传流行病学和基因组学新研究技能所需的结构化课程,指导和应用学习。结构化的学习经验将包括正式的课程和研讨会,定期的地方会议,并出席科学会议。他将利用关键的当地资源,在他的导师所在的中心开展拟议的研究和培训,包括VA西雅图流行病学研究和信息中心(他是一名研究员),VET登记处,以及华盛顿大学的基因组科学系和比较有效性,成本和结果研究中心(专门从事背痛研究)。这种出色的当地环境将有助于确保Suriyaarachchi博士的成功。

项目成果

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Pradeep Suri其他文献

Pradeep Suri的其他文献

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{{ truncateString('Pradeep Suri', 18)}}的其他基金

Identifying genetic predictors of outcomes for Veterans with chronic low back pain and lumbosacral spinal disorders
确定患有慢性腰痛和腰骶脊柱疾病的退伍军人结果的遗传预测因素
  • 批准号:
    10641238
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Effects of Physical Activities on Pain and Functional Recovery in Low Back Pain
体力活动对腰痛疼痛和功能恢复的影响
  • 批准号:
    10377320
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
Effects of Physical Activities on Pain and Functional Recovery in Low Back Pain
体力活动对腰痛疼痛和功能恢复的影响
  • 批准号:
    10610319
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
Combined Treatments to Optimize Functional Recovery in Veterans with Chronic Low Back Pain
联合治疗可优化患有慢性腰痛的退伍军人的功能恢复
  • 批准号:
    10174853
  • 财政年份:
    2018
  • 资助金额:
    --
  • 项目类别:
Resource Core
资源核心
  • 批准号:
    10680539
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
Resource Core
资源核心
  • 批准号:
    10475476
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
A Twin Study of Chronic Back Pain and Associated Disability in Veterans
退伍军人慢性背痛和相关残疾的双胞胎研究
  • 批准号:
    8784821
  • 财政年份:
    2014
  • 资助金额:
    --
  • 项目类别:

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